Domaines d’expertise
Organic synthesis
Asymmetric catalysis
Synthesis and conformational analysis of peptides and peptidomimetics
Radical chemistry
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Disciplines
Mots-clefs
12-Diamine Amino acids Asymmetric aldol reaction Asymmetric catalysis Asymmetric synthesis Ball-mill Bicyclic beta-amino acid Catalyse asymétrique Chemical biology Chiral ligands Circular dichroism Conformational analysis Copper Cytotoxicity Fluorinated compounds Fluorinated peptides Foldamers Foldamères HCT116 Organocatalysis
- Foldamers2
- Organocatalysis2
- 12-Diamine1
- Amino acids1
- Asymmetric aldol reaction1
- Asymmetric catalysis1
- Asymmetric synthesis1
- Ball-mill1
- Bicyclic beta-amino acid1
- Catalyse asymétrique1
- Chemical biology1
- Chiral ligands1
- Circular dichroism1
- Conformational analysis1
- Copper1
- Cytotoxicity1
- Fluorinated compounds1
- Fluorinated peptides1
- Foldamères1
- HCT1161
- Helical structures1
- Ligands chiraux1
- Manganese Complex1
- Mechanochemistry1
- Mechanosynthesis1
- Medicinal1
- Medicinal chemistry1
- Nickel1
- Oligoureas1
- Oligourées1
- Organocatalyse1
- Palladium1
- Peptides1
- Salen metal complex1
- Short alpha/beta-peptide1
- X-ray1
Auteurs
Milbeo Pierre11
Martinez Jean7
Didierjean Claude5
Aubert Emmanuel5
Moulat Laure4
Calmès Monique3
Legrand Baptiste3
Amblard Muriel3
Calmes Monique3
Simon Matthieu2
Wenger Emmanuel2
Chaume Grégory2
Brigaud Thierry2
Alphey Magnus1
Andre Christophe1
Beucher Hélène1
Bodero Lizeth1
Boutahri Yazid1
Calmes Monique1
Kempf Karl1
Kempf Oxana1
Lebrêne Arthur1
Liu Hongtao1
Lynch Dylan1
Maurent Kelly1
Mclean Joshua1
Mcsweeney Lauren1
Oudeyer Sylvain1
Picois Nathan1
Pirrie Lisa1
Quintin François1
Savchuk Mariia1
Tran Fanny1
Xiao Ganyuan1
Zhou Yi1
Lebrun Aurelien1
Vo-Thanh Giang1
Picois Nathan1
Scanlan Eoin1
Bickel Jasmine1
Westwood Nicholas1
Brière Jean-François1
Lamaty Frédéric1
Bantreil Xavier1
Milbeo Pierre T1
Milbéo Pierre1
Zanato Chiara1
Lensen Nathalie1
Naismith James1
Auteurs de la structure
Revues
Institutions
Laboratoires
Départements
Équipes de recherche
13 documents
Articles dans une revue12 document
- Nathan Picois, Yazid Boutahri, Pierre Milbeo, Chiara Zanato, Nathalie Lensen, et al.. Asymmetric α-Fluoroalkyl-α-Amino Acids: Recent Advances in Their Synthesis and Applications. Molecules, 2024, 29 (6), pp.1408. ⟨10.3390/molecules29061408⟩. ⟨hal-04516441⟩
- Nathan Picois, Lizeth Bodero, Pierre T Milbeo, Thierry Brigaud, Grégory Chaume. Bimodal use of chiral α‐Trifluoromethylalanine in Aib Foldamers: study of the position impact towards the helical screw‐sense preference. Chemistry - A European Journal, In press, ⟨10.1002/chem.202400540⟩. ⟨hal-04516499⟩
- Pierre Milbeo, Arthur Lebrêne, Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, et al.. An Organocatalytic and Stereoselective Vinylogous Domino Process Towards Thiochromans. Chemistry - A European Journal, 2023, pp.e202301311. ⟨10.1002/chem.202301311⟩. ⟨hal-04102949⟩
- Ganyuan Xiao, Magnus Alphey, Fanny Tran, Lisa Pirrie, Pierre Milbeo, et al.. Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorganic and Medicinal Chemistry, 2021, 50, pp.116477. ⟨10.1016/j.bmc.2021.116477⟩. ⟨hal-05087058⟩
- Joshua Mclean, Pierre Milbeo, Dylan Lynch, Lauren Mcsweeney, Eoin Scanlan. Radical‐Mediated Acyl Thiol‐Ene Reaction for Rapid Synthesis of Biomolecular Thioester Derivatives. European Journal of Organic Chemistry, 2021, 2021 (29), pp.4148-4160. ⟨10.1002/ejoc.202100615⟩. ⟨hal-05087069⟩
- Pierre Milbeo, François Quintin, Laure Moulat, Claude Didierjean, Jean Martinez, et al.. Synthesis, characterisation and cytotoxic activity evaluation of new metal-salen complexes based on the 1,2-bicyclo[2.2.2]octane bridge. Tetrahedron Letters, 2021, 63, pp.152706. ⟨10.1016/j.tetlet.2020.152706⟩. ⟨hal-03103305⟩
- Pierre Milbeo, Jean Martinez, Muriel Amblard, Monique Calmès, Baptiste Legrand. 1-Aminobicyclo[2.2.2]octane-2-carboxylic acid and derivatives as chiral constrained bridged scaffolds for foldamers and chiral catalysts. Accounts of Chemical Research, 2021, 54 (3), pp.685-696. ⟨10.1021/acs.accounts.0c00680⟩. ⟨hal-03371473⟩
- Pierre Milbeo, Matthieu Simon, Claude Didierjean, Emmanuel Wenger, Emmanuel Aubert, et al.. A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas. Chemical Communications, 2020, 56 (57), pp.7921-7924. ⟨10.1039/d0cc02902e⟩. ⟨hal-03080580⟩
- Matthieu Simon, Pierre Milbeo, Hongtao Liu, Christophe Andre, Emmanuel Wenger, et al.. 12/10‐Helix in Mixed β‐Peptides Alternating Bicyclic and Acyclic β‐Amino Acids: Probing the Relationship between Bicyclic Side Chain and Helix Stability. Chemistry - A European Journal, 2018, 24 (70), pp.18795-18800. ⟨10.1002/chem.201804404⟩. ⟨hal-02403147⟩
- Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, et al.. C 1 -Symmetric 1,2-Diaminobicyclo[2.2.2]octane Ligands in Copper-Catalyzed Asymmetric Henry Reaction: Catalyst Development and DFT Studies. European Journal of Organic Chemistry, 2018, 2018 (2), pp.178-187. ⟨10.1002/ejoc.201701452⟩. ⟨hal-02419329⟩
- Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, et al.. Synthesis of Enantiopure 1,2-Diaminobicyclo[2.2.2]octane Derivatives, C 1 -Symmetric Chiral 1,2-Diamines with a Rigid Bicyclic Backbone. Journal of Organic Chemistry, 2017, 82 (6), pp.3144 - 3151. ⟨10.1021/acs.joc.7b00122⟩. ⟨hal-01552321⟩
- Pierre Milbeo, Kelly Maurent, Laure Moulat, Aurelien Lebrun, Claude Didierjean, et al.. N-Pyrrolidine-based alpha/beta-peptides incorporating ABOC, a constrained bicyclic beta-amino acid, for asymmetric aldol reaction catalysis. Tetrahedron, 2016, 72 (13), pp.1706-1715. ⟨10.1016/j.tet.2016.02.027⟩. ⟨hal-01532027⟩
Thèses1 document
- Pierre Milbéo. Synthèse de bicycles contraints originaux pour l’élaboration de nouveaux catalyseurs chiraux et de nouveaux foldamères. Chimie organique. Université Montpellier, 2017. Français. ⟨NNT : 2017MONTT209⟩. ⟨tel-03824580⟩
Professional experience :
- Sept 2021-Present : Associate Professor at CY Cergy-Paris Université/BioCIS-ECB
- Nov 2020- June 2021: Postdoctoral fellow INSA-Rouen
Group of Dr Levacher and Dr Brière, UMR COBRA, Université de Rouen, France - June-Nov 2020 : Postdoctoral fellow INSA-Rouen/Oril Industrie (Servier)
Laboratoire commun IDECHEM, UMR COBRA, Université de Rouen, France - 2018-2020: Science Foundation Ireland Postdoctoral Fellow
Group of Prof. Eoin Scanlan, School of Chemistry, Trinity College Dublin, Ireland - 2014-2017: PhD student University of Montpellier
Group of Dr. Monique Calmès, Institut des Biomolécules Max Mousseron (IBMM), France - Sept 2013-May 2014: Final year master project
Group of Prof. Nicholas Westwood, School of chemistry, University of St Andrews, UK - July-August 2013: Two-month placement
Group of Prof. Mark Bagley, School of life science, University of Sussex, Brighton, UK
Education:
- 2014-2017: Université de Montpellier, Hérault, France. PhD
- 2013-2014: University of St Andrews, Scotland, UK. MChem degree within an exchange program with ENSCL
- 2013-2014: Université de Lille 1, Nord, France. Master in chemistry and biology with organic chemistry.
- 2011-2014: Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Nord, France. Engineering degree in Chemistry
Funded research projects and awards :
- Selected member of the EUTOPIA Young Leader Academy (2nd cohort : 2023-2025)
- CY Initiative Emergence : FAstPhox 2022-2024 « Fluorinated peptides as organocatalysts in asymmetric photoredox reactions »