Pierre MILBEO 

Maître de Conférences


Chimie Biologique, Permanent

0134257380

Site de Cergy

Permanent

Domaines d’expertise

Organic synthesis
Asymmetric catalysis
Synthesis and conformational analysis of peptides and peptidomimetics
Radical chemistry


13 documents


Articles dans une revue

  • Nathan Picois, Yazid Boutahri, Pierre Milbeo, Chiara Zanato, Nathalie Lensen, et al.. Asymmetric α-Fluoroalkyl-α-Amino Acids: Recent Advances in Their Synthesis and Applications. Molecules, 2024, 29 (6), pp.1408. ⟨10.3390/molecules29061408⟩. ⟨hal-04516441⟩
  • Nathan Picois, Lizeth Bodero, Pierre T Milbeo, Thierry Brigaud, Grégory Chaume. Bimodal use of chiral α‐Trifluoromethylalanine in Aib Foldamers: study of the position impact towards the helical screw‐sense preference. Chemistry - A European Journal, In press, ⟨10.1002/chem.202400540⟩. ⟨hal-04516499⟩
  • Pierre Milbeo, Arthur Lebrêne, Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, et al.. An Organocatalytic and Stereoselective Vinylogous Domino Process Towards Thiochromans. Chemistry - A European Journal, 2023, pp.e202301311. ⟨10.1002/chem.202301311⟩. ⟨hal-04102949⟩
  • Ganyuan Xiao, Magnus Alphey, Fanny Tran, Lisa Pirrie, Pierre Milbeo, et al.. Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorganic and Medicinal Chemistry, 2021, 50, pp.116477. ⟨10.1016/j.bmc.2021.116477⟩. ⟨hal-05087058⟩
  • Joshua Mclean, Pierre Milbeo, Dylan Lynch, Lauren Mcsweeney, Eoin Scanlan. Radical‐Mediated Acyl Thiol‐Ene Reaction for Rapid Synthesis of Biomolecular Thioester Derivatives. European Journal of Organic Chemistry, 2021, 2021 (29), pp.4148-4160. ⟨10.1002/ejoc.202100615⟩. ⟨hal-05087069⟩
  • Pierre Milbeo, François Quintin, Laure Moulat, Claude Didierjean, Jean Martinez, et al.. Synthesis, characterisation and cytotoxic activity evaluation of new metal-salen complexes based on the 1,2-bicyclo[2.2.2]octane bridge. Tetrahedron Letters, 2021, 63, pp.152706. ⟨10.1016/j.tetlet.2020.152706⟩. ⟨hal-03103305⟩
  • Pierre Milbeo, Jean Martinez, Muriel Amblard, Monique Calmès, Baptiste Legrand. 1-Aminobicyclo[2.2.2]octane-2-carboxylic acid and derivatives as chiral constrained bridged scaffolds for foldamers and chiral catalysts. Accounts of Chemical Research, 2021, 54 (3), pp.685-696. ⟨10.1021/acs.accounts.0c00680⟩. ⟨hal-03371473⟩
  • Pierre Milbeo, Matthieu Simon, Claude Didierjean, Emmanuel Wenger, Emmanuel Aubert, et al.. A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas. Chemical Communications, 2020, 56 (57), pp.7921-7924. ⟨10.1039/d0cc02902e⟩. ⟨hal-03080580⟩
  • Matthieu Simon, Pierre Milbeo, Hongtao Liu, Christophe Andre, Emmanuel Wenger, et al.. 12/10‐Helix in Mixed β‐Peptides Alternating Bicyclic and Acyclic β‐Amino Acids: Probing the Relationship between Bicyclic Side Chain and Helix Stability. Chemistry - A European Journal, 2018, 24 (70), pp.18795-18800. ⟨10.1002/chem.201804404⟩. ⟨hal-02403147⟩
  • Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, et al.. C 1 -Symmetric 1,2-Diaminobicyclo[2.2.2]octane Ligands in Copper-Catalyzed Asymmetric Henry Reaction: Catalyst Development and DFT Studies. European Journal of Organic Chemistry, 2018, 2018 (2), pp.178-187. ⟨10.1002/ejoc.201701452⟩. ⟨hal-02419329⟩
  • Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, et al.. Synthesis of Enantiopure 1,2-Diaminobicyclo[2.2.2]octane Derivatives, C 1 -Symmetric Chiral 1,2-Diamines with a Rigid Bicyclic Backbone. Journal of Organic Chemistry, 2017, 82 (6), pp.3144 - 3151. ⟨10.1021/acs.joc.7b00122⟩. ⟨hal-01552321⟩
  • Pierre Milbeo, Kelly Maurent, Laure Moulat, Aurelien Lebrun, Claude Didierjean, et al.. N-Pyrrolidine-based alpha/beta-peptides incorporating ABOC, a constrained bicyclic beta-amino acid, for asymmetric aldol reaction catalysis. Tetrahedron, 2016, 72 (13), pp.1706-1715. ⟨10.1016/j.tet.2016.02.027⟩. ⟨hal-01532027⟩


Thèses

  • Pierre Milbéo. Synthèse de bicycles contraints originaux pour l’élaboration de nouveaux catalyseurs chiraux et de nouveaux foldamères. Chimie organique. Université Montpellier, 2017. Français. ⟨NNT : 2017MONTT209⟩. ⟨tel-03824580⟩


Professional experience :

  • Sept 2021-Present : Associate Professor at CY Cergy-Paris Université/BioCIS-ECB
  • Nov 2020- June 2021: Postdoctoral fellow INSA-Rouen
    Group of Dr Levacher and Dr Brière, UMR COBRA, Université de Rouen, France
  • June-Nov 2020 : Postdoctoral fellow INSA-Rouen/Oril Industrie (Servier)
    Laboratoire commun IDECHEM, UMR COBRA, Université de Rouen, France
  • 2018-2020: Science Foundation Ireland Postdoctoral Fellow
    Group of Prof. Eoin Scanlan, School of Chemistry, Trinity College Dublin, Ireland
  • 2014-2017: PhD student University of Montpellier
    Group of Dr. Monique Calmès, Institut des Biomolécules Max Mousseron (IBMM), France
  • Sept 2013-May 2014: Final year master project
    Group of Prof. Nicholas Westwood, School of chemistry, University of St Andrews, UK
  • July-August 2013: Two-month placement
    Group of Prof. Mark Bagley, School of life science, University of Sussex, Brighton, UK

Education:

  • 2014-2017: Université de Montpellier, Hérault, France. PhD
  • 2013-2014: University of St Andrews, Scotland, UK. MChem degree within an exchange program with ENSCL
  • 2013-2014: Université de Lille 1, Nord, France. Master in chemistry and biology with organic chemistry.
  • 2011-2014: Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Nord, France. Engineering degree in Chemistry

Funded research projects and awards :

  • Selected member of the EUTOPIA Young Leader Academy (2nd cohort : 2023-2025)
  • CY Initiative Emergence : FAstPhox 2022-2024 « Fluorinated peptides as organocatalysts in asymmetric photoredox reactions »