Domaines d’expertise
Organic synthesis
Asymmetric catalysis
Synthesis and conformational analysis of peptides and peptidomimetics
Radical chemistry
Contact
- Nom : Pierre Milbéo
- IdHAL : pierre-milbeo
- CV HAL : CV de Pierre Milbéo
- ORCID : 0000-0002-6199-6636 ,
Disciplines
Mots-clefs
12-Diamine Amino acids Asymmetric aldol reaction Asymmetric catalysis Asymmetric synthesis Ball-mill Bicyclic beta-amino acid Catalyse asymétrique Chemical biology Chiral ligands Circular dichroism Conformational analysis Copper Cytotoxicity Fluorinated compounds Fluorinated peptides Foldamers Foldamères HCT116 Organocatalysis
- Foldamers2
- Organocatalysis2
- 12-Diamine1
- Amino acids1
- Asymmetric aldol reaction1
- Asymmetric catalysis1
- Asymmetric synthesis1
- Ball-mill1
- Bicyclic beta-amino acid1
- Catalyse asymétrique1
- Chemical biology1
- Chiral ligands1
- Circular dichroism1
- Conformational analysis1
- Copper1
- Cytotoxicity1
- Fluorinated compounds1
- Fluorinated peptides1
- Foldamères1
- HCT1161
- Helical structures1
- Ligands chiraux1
- Manganese Complex1
- Mechanochemistry1
- Mechanosynthesis1
- Medicinal1
- Medicinal chemistry1
- Nickel1
- Oligoureas1
- Oligourées1
- Organocatalyse1
- Palladium1
- Peptides1
- Salen metal complex1
- Short alpha/beta-peptide1
- X-ray1
Auteurs
Milbeo Pierre11- Martinez Jean7
- Didierjean Claude5
- Aubert Emmanuel5
- Moulat Laure4
- Calmès Monique3
- Legrand Baptiste3
- Amblard Muriel3
- Calmes Monique3
- Simon Matthieu2
- Brigaud Thierry2
- Wenger Emmanuel2
- Milbéo Pierre2
- Zanato Chiara2
- Chaume Grégory2
- Alphey Magnus1
- Andre Christophe1
- Beucher Hélène1
- Bodero Lizeth1
- Boutahri Yazid1
- Calmes Monique1
- Kempf Karl1
- Kempf Oxana1
- Lebrêne Arthur1
- Liu Hongtao1
- Lynch Dylan1
- Maurent Kelly1
- Mclean Joshua1
- Mcsweeney Lauren1
- Oudeyer Sylvain1
- Picois Nathan1
- Pirrie Lisa1
- Quintin François1
- Savchuk Mariia1
- Tran Fanny1
- Xiao Ganyuan1
- Zhou Yi1
- Lebrun Aurelien1
- Vo-Thanh Giang1
- Picois Nathan1
- Scanlan Eoin1
- Bickel Jasmine1
- Westwood Nicholas1
- Brière Jean-François1
- Lamaty Frédéric1
- Bantreil Xavier1
- Milbeo Pierre T1
- Lensen Nathalie1
- Naismith James1
Auteurs de la structure
Revues
Institutions
Laboratoires
Départements
Équipes de recherche
14 documents
Articles dans une revue12 document
- Nathan Picois, Yazid Boutahri, Pierre Milbeo, Chiara Zanato, Nathalie Lensen, et al.. Asymmetric α-Fluoroalkyl-α-Amino Acids: Recent Advances in Their Synthesis and Applications. Molecules, 2024, 29 (6), pp.1408. ⟨10.3390/molecules29061408⟩. ⟨hal-04516441⟩
- Nathan Picois, Lizeth Bodero, Pierre T Milbeo, Thierry Brigaud, Grégory Chaume. Bimodal use of chiral α‐Trifluoromethylalanine in Aib Foldamers: study of the position impact towards the helical screw‐sense preference. Chemistry - A European Journal, In press, ⟨10.1002/chem.202400540⟩. ⟨hal-04516499⟩
- Pierre Milbeo, Arthur Lebrêne, Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, et al.. An Organocatalytic and Stereoselective Vinylogous Domino Process Towards Thiochromans. Chemistry - A European Journal, 2023, pp.e202301311. ⟨10.1002/chem.202301311⟩. ⟨hal-04102949⟩
- Ganyuan Xiao, Magnus Alphey, Fanny Tran, Lisa Pirrie, Pierre Milbeo, et al.. Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorganic and Medicinal Chemistry, 2021, 50, pp.116477. ⟨10.1016/j.bmc.2021.116477⟩. ⟨hal-05087058⟩
- Joshua Mclean, Pierre Milbeo, Dylan Lynch, Lauren Mcsweeney, Eoin Scanlan. Radical‐Mediated Acyl Thiol‐Ene Reaction for Rapid Synthesis of Biomolecular Thioester Derivatives. European Journal of Organic Chemistry, 2021, 2021 (29), pp.4148-4160. ⟨10.1002/ejoc.202100615⟩. ⟨hal-05087069⟩
- Pierre Milbeo, Jean Martinez, Muriel Amblard, Monique Calmès, Baptiste Legrand. 1-Aminobicyclo[2.2.2]octane-2-carboxylic acid and derivatives as chiral constrained bridged scaffolds for foldamers and chiral catalysts. Accounts of Chemical Research, 2021, 54 (3), pp.685-696. ⟨10.1021/acs.accounts.0c00680⟩. ⟨hal-03371473⟩
- Pierre Milbeo, François Quintin, Laure Moulat, Claude Didierjean, Jean Martinez, et al.. Synthesis, characterisation and cytotoxic activity evaluation of new metal-salen complexes based on the 1,2-bicyclo[2.2.2]octane bridge. Tetrahedron Letters, 2021, 63, pp.152706. ⟨10.1016/j.tetlet.2020.152706⟩. ⟨hal-03103305⟩
- Pierre Milbeo, Matthieu Simon, Claude Didierjean, Emmanuel Wenger, Emmanuel Aubert, et al.. A bicyclic unit reversal to stabilize the 12/14-helix in mixed homochiral oligoureas. Chemical Communications, 2020, 56 (57), pp.7921-7924. ⟨10.1039/d0cc02902e⟩. ⟨hal-03080580⟩
- Matthieu Simon, Pierre Milbeo, Hongtao Liu, Christophe Andre, Emmanuel Wenger, et al.. 12/10‐Helix in Mixed β‐Peptides Alternating Bicyclic and Acyclic β‐Amino Acids: Probing the Relationship between Bicyclic Side Chain and Helix Stability. Chemistry - A European Journal, 2018, 24 (70), pp.18795-18800. ⟨10.1002/chem.201804404⟩. ⟨hal-02403147⟩
- Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, et al.. C 1 -Symmetric 1,2-Diaminobicyclo[2.2.2]octane Ligands in Copper-Catalyzed Asymmetric Henry Reaction: Catalyst Development and DFT Studies. European Journal of Organic Chemistry, 2018, 2018 (2), pp.178-187. ⟨10.1002/ejoc.201701452⟩. ⟨hal-02419329⟩
- Pierre Milbeo, Laure Moulat, Claude Didierjean, Emmanuel Aubert, Jean Martinez, et al.. Synthesis of Enantiopure 1,2-Diaminobicyclo[2.2.2]octane Derivatives, C 1 -Symmetric Chiral 1,2-Diamines with a Rigid Bicyclic Backbone. Journal of Organic Chemistry, 2017, 82 (6), pp.3144 - 3151. ⟨10.1021/acs.joc.7b00122⟩. ⟨hal-01552321⟩
- Pierre Milbeo, Kelly Maurent, Laure Moulat, Aurelien Lebrun, Claude Didierjean, et al.. N-Pyrrolidine-based alpha/beta-peptides incorporating ABOC, a constrained bicyclic beta-amino acid, for asymmetric aldol reaction catalysis. Tetrahedron, 2016, 72 (13), pp.1706-1715. ⟨10.1016/j.tet.2016.02.027⟩. ⟨hal-01532027⟩
Chapitres d'ouvrage1 document
- Pierre Milbéo, Chiara Zanato. The Thiol-ene “Click” Reaction for Synthesis of Biomolecular Thioether and Thioester Derivatives. Topics Heterocyclic Chemistry. Modern Advances in Click Chemistry: Synthesis of Compounds, Springer Berlin Heidelberg, In press, Topics in Heterocyclic Chemistry, ⟨10.1007/7081_2025_98⟩. ⟨hal-05479896⟩
Thèses1 document
- Pierre Milbéo. Synthèse de bicycles contraints originaux pour l’élaboration de nouveaux catalyseurs chiraux et de nouveaux foldamères. Chimie organique. Université Montpellier, 2017. Français. ⟨NNT : 2017MONTT209⟩. ⟨tel-03824580⟩
Documents récupérés de l'archive ouverte HAL 
Professional experience :
- Sept 2021-Present : Associate Professor at CY Cergy-Paris Université/BioCIS-ECB
- Nov 2020- June 2021: Postdoctoral fellow INSA-Rouen
Group of Dr Levacher and Dr Brière, UMR COBRA, Université de Rouen, France - June-Nov 2020 : Postdoctoral fellow INSA-Rouen/Oril Industrie (Servier)
Laboratoire commun IDECHEM, UMR COBRA, Université de Rouen, France - 2018-2020: Science Foundation Ireland Postdoctoral Fellow
Group of Prof. Eoin Scanlan, School of Chemistry, Trinity College Dublin, Ireland - 2014-2017: PhD student University of Montpellier
Group of Dr. Monique Calmès, Institut des Biomolécules Max Mousseron (IBMM), France - Sept 2013-May 2014: Final year master project
Group of Prof. Nicholas Westwood, School of chemistry, University of St Andrews, UK - July-August 2013: Two-month placement
Group of Prof. Mark Bagley, School of life science, University of Sussex, Brighton, UK
Education:
- 2014-2017: Université de Montpellier, Hérault, France. PhD
- 2013-2014: University of St Andrews, Scotland, UK. MChem degree within an exchange program with ENSCL
- 2013-2014: Université de Lille 1, Nord, France. Master in chemistry and biology with organic chemistry.
- 2011-2014: Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Nord, France. Engineering degree in Chemistry
Funded research projects and awards :
- Selected member of the EUTOPIA Young Leader Academy (2nd cohort : 2023-2025)
- CY Initiative Emergence : FAstPhox 2022-2024 « Fluorinated peptides as organocatalysts in asymmetric photoredox reactions »