The cover picture, provided by Abdallah Hamze and co-workers, reports an efficient one-pot metal-catalyzed process between N-tosyl- hydrazones, N-(dihalophenyl)-imidates, and amines. During this trans- formation, one C C bond and two C N bonds were created by a single palladium-catalyzed reaction leading to a library of 5-(1-aryl- vinyl)-1H-benzimidazoles. Imidates were found to be an ideal partner for the cross-coupling with hydrazones in comparison with acet- amides. Among several derivatives evaluated, one compound exhibits excellent antiproliferative activity in the nanomolar concentration range. Details can be found in the full paper on pages xxxx–xxxx (T. Naret, P. Retailleau, J. Bignon, J.-D. Brion, M. Alami, A. Hamze, Adv. Synth. Catal. 2016, 358, xxxx–xxxx ; DOI : 10.1002/ adsc.201600173).