Research Topics
Fluorinated Peptides: Synthesis and biological evaluation of several trifluoromethylated GPE analogs (ANR JCJC 2009, CF3-GPE, PI: G. Chaume). Introduction of trifluoromethylated amino acids in peptides: impact on hydrophobicity and proteolytic resistance. Trifluoromethylated peptides as NMR Probes (ANR CH2-Probe, ANR F-LAIR).
Enantiopure Fluorinated Synthons: Synthesis of trifluoromethylated enantiopur Amino Alcohols, Amino Acids and Diamines: application to the synthesis of trifluoromethylated polyureas Foldamers.
Assymetric Synthesis: Use of Fox (fluorinated oxazolidine) Chiral Auxiliary in diastereoselective transformation of amide enolates (alkylation, oxydation, fluoration)
Contact
Disciplines
Mots-clefs
Aspartic protease inhibitors Asymmetry Beta ketoester reduction Cathepsin D Chiral N-heterocyclic carbenes Conjugate addition Copper Copper catalysed Dialkylzinc Enantioselective Fluorinated amino acids Fluorinated chiral auxiliaries Fluorinated chiral compounds Fluorinated peptides Imidazolinium salts Leucine Michael acceptors N-alkylated peptides N-heterocyclic carbenes Ovarian cancer
- Conjugate addition2
- Fluorinated peptides2
- Aspartic protease inhibitors1
- Asymmetry1
- Beta ketoester reduction1
- Cathepsin D1
- Chiral N-heterocyclic carbenes1
- Copper1
- Copper catalysed1
- Dialkylzinc1
- Enantioselective1
- Fluorinated amino acids1
- Fluorinated chiral auxiliaries1
- Fluorinated chiral compounds1
- Imidazolinium salts1
- Leucine1
- Michael acceptors1
- N-alkylated peptides1
- N-heterocyclic carbenes1
- Ovarian cancer1
- Pepstatin A1
- Peptide inhibitors1
- SilverI1
- Statines1
- Trifluoromethionine1
Auteurs
Pytkowicz Julien13- Chelain Evelyne4
- Simon Julien3
- Lensen Nathalie3
- Alexakis Alexandre2
- Brigaud Thierry2
- Chelain Evelyne2
- Mangeney Pierre2
- Terzani Francesco2
- Roland Sylvain2
- Guillen F.2
- Zanato Chiara2
- Brigaud Thierry2
- Devillers Emmanuelle2
- Chaume Gregory2
- Brigaud Thierry2
- Belhattab Sherazade1
- Besbes Rafâa1
- Carlier Ludovic1
- Carreiras Franck1
- Dalvit Claudio1
- Davidson Stephanie1
- El Guermah Lamia1
- Gineste Anthony1
- Kellouche-Gaillard Sabrina1
- Le Guern Aurore1
- Leroy-Dudal Johanne1
- Meneghelli Lorenzo1
- Ouerfelli Oussema1
- Pech-Janody Rasmei1
- Pietri Marine1
- Rémy Gilles1
- Saraiva Rosa Nathalie1
- Winn Caroline L.1
- Winn Caroline l.1
- Zanato Chiara1
- Leroy-Dudal Johanne1
- Guitot Karine1
- Miclet Emeric1
- Brigaud Thierry1
- Monasson Olivier1
- Chelain Evelyne1
- Larregola Maud1
- Nadal Simon1
- Leturmy Pascale1
- Picot Cédric R.1
- Lionel Vido1
- Gadais Charlène1
- Dang Ngoc Tuyêt Trâm1
- Chaume Grégory1
- Ben Haj Salah Khoubaib1
Auteurs de la structure
Revues
Institutions
Laboratoires
Départements
Équipes de recherche
13 documents
Articles dans une revue12 document
- Lorenzo Meneghelli, Stephanie Davidson, Anthony Gineste, Lamia El Guermah, Sabrina Kellouche-Gaillard, et al.. Design and synthesis of a clickable cell-permeable pseudopeptide Pin1 inhibitor with antiproliferative effects on human multiple myeloma cell line. Chemical Communications, 2025, ⟨10.1039/D4CC05968A⟩. ⟨hal-05003977⟩
- Julien Pytkowicz, Grégory Chaume, Nathalie Lensen, Evelyne Chelain, Thierry Brigaud. Two decades of fluorine chemistry in Cergy. Comptes Rendus. Chimie, 2024, 27 (G1), pp.353-383. ⟨10.5802/crchim.360⟩. ⟨hal-04823676⟩
- Francesco Terzani, Sherazade Belhattab, Aurore Le Guern, Karine Guitot, Olivier Monasson, et al.. Synthesis and biological evaluation of selective Pepstatin based trifluoromethylated inhibitors of Cathepsin D. European Journal of Medicinal Chemistry, 2024, 267, pp.116178. ⟨10.1016/j.ejmech.2024.116178⟩. ⟨hal-04455850⟩
- Emmanuelle Devillers, Evelyne Chelain, Claudio Dalvit, Thierry Brigaud, Julien Pytkowicz. ( R )‐α‐Trifluoromethylalanine as a 19 F NMR Probe for the Monitoring of Protease Digestion of Peptides. ChemBioChem, 2022, 23 (1), pp.e202100470. ⟨10.1002/cbic.202100470⟩. ⟨hal-03549211⟩
- Khoubaib Ben Haj Salah, Francesco Terzani, Marine Pietri, Chiara Zanato, Evelyne Chelain, et al.. Highly stereoselective multigram scale synthesis of (3S,4S)-Statine and (3S,4S)-N-Benzylstatine. Results in Chemistry, 2022, 4, pp.100333. ⟨10.1016/j.rechem.2022.100333⟩. ⟨hal-04098168⟩
- Oussema Ouerfelli, Julien Simon, Evelyne Chelain, Julien Pytkowicz, Rafâa Besbes, et al.. Enantiopure α-Trifluoromethylated Aziridine-2-carboxylic Acid (α-TfmAzy) : Synthesis and Peptide Coupling. Organic Letters, 2020, 22 (8), pp.2946-2949. ⟨10.1021/acs.orglett.0c00645⟩. ⟨hal-03549179⟩
- Thierry Brigaud, Charlène Gadais, Julien Pytkowicz, Evelyne Chelain, Nathalie Saraiva Rosa. Tailored Approaches towards the Synthesis of l-S-(Trifluoromethyl)cysteine- and l-Trifluoromethionine-Containing Peptides. European Journal of Organic Chemistry, 2017, 2, pp.246-251. ⟨10.1002/ejoc.201601318⟩. ⟨hal-02980393⟩
- Gregory Chaume, Julien Simon, Nathalie Lensen, Julien Pytkowicz, Thierry Brigaud, et al.. Homochiral versus Heterochiral Trifluoromethylated Pseudoproline Containing Dipeptides: A Powerful Tool to Switch the Prolyl-Amide Bond Conformation. Journal of Organic Chemistry, 2017, 82 (24), pp.13602-13608. ⟨10.1021/acs.joc.7b01944⟩. ⟨hal-01675297⟩
- Julien Pytkowicz, Gregory Chaume, Nathalie Lensen, Julien Simon, Thierry Brigaud. Incorporation of Trifluoromethylated Proline and Surrogates into Peptides: Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide. Journal of Organic Chemistry, 2016, 13, pp.5381-5392. ⟨10.1021/acs.joc.6b00704⟩. ⟨hal-02980190⟩
- Thierry Brigaud, Emmanuelle Devillers, Evelyne Chelain, Julien Pytkowicz. Synthesis of Protected Enantiopure (R) and (S)-a-Trifluoromethylalanine Containing Dipeptide Building Blocks Ready to Use for Solid Phase Peptide Synthesis.. Amino Acids, 2016, 6, pp.1457-1468. ⟨10.1007/s00726-016-2200-9⟩. ⟨hal-02980191⟩
- Caroline L. Winn, F. Guillen, Julien Pytkowicz, Sylvain Roland, Pierre Mangeney, et al.. Enantioselective copper catalysed 1,4-conjugate addition reactions using chiral N-heterocyclic carbenes. Journal of Organometallic Chemistry, 2005, 690 (24-25), pp.5672. ⟨10.1016/j.jorganchem.2005.07.024⟩. ⟨hal-01147004⟩
- Alexandre Alexakis, Caroline l. Winn, F. Guillen, Julien Pytkowicz, Sylvain Roland, et al.. Asymmetric Synthesis withN-Heterocyclic Carbenes. Application to the Copper-Catalyzed Conjugate Addition. Advanced Synthesis and Catalysis, 2003, 345 (3), pp.345. ⟨10.1002/adsc.200390037⟩. ⟨hal-01146999⟩
Communications dans un congrès1 document
- Tuyêt Trâm Dang Ngoc, Johanne Leroy-Dudal, Pascale Leturmy, Rasmei Pech-Janody, Cédric R. Picot, et al.. L’Intelligence Collective comme Levier d'Engagement et de Mise en Action dans la Conception et Déploiement d’une Unité d’Enseignement Transversale et Interdisciplinaire à Grande Échelle : l’UE CATI. Questions Pour l’Enseignement Supérieur (QPES), Jan 2022, La Rochelle, France. ⟨hal-03597039⟩
Documents récupérés de l'archive ouverte HAL 
Scientific Career
2018 Professor CY University BioCIS laboratory (UMR 8076)
2017 CNU Qualification (32nd section)
2012 « Habilitation à Diriger des Recherches » (HDR Cergy Pontoise University)
2004 Assistant professor (32nd section) SOSCO (U.M.R 8123) Cergy Pontoise University, Pr. Thierry Brigaud’s team.
2003-2004 ATER in the Molecular Catalysis Laboratory (U.M.R 8182) Paris-Sud University, Pr. Henri Kagan’s supervision.
2002-2003 Post-doctoral position, Montreal University (UdM) André Charrette’s Laboratory
1999-2002 PhD in Organic Chemistry under supervision of D.R. Pierre Mangeney in the Organic Chemistry Laboratory(UMR 7611)
Scientific Impact
- 2021 INEX Emergence Program « FSIPRO »
- 2018 ANR « F-LAIR » program (contributor)
- 2017 ANR « CH2-Probe » program (contributor)
- 2016 funding of UCP foundation « FOLDAFLU » project
- 2016 Co-organization of the GIS Fluor thematic day « Fluor et Biomolécules : de l’acide aminé aux protéines »
- 2014 Co-organization of the “Colloque Francophone de Chimie du Fluor CFCF”
- 2009 P.E.S Grant
- 2009 ANR JCJC« CF3-GPE » (contributor)
- Since 2008 Member of the G.I.S. « Fluor » (CNRS) and member of GFPP (Groupe Français des Peptides et des Protéines)