Sandrine ONGERI 

Professeure

Responsable équipe FLUOPEPIT - Directrice Graduate School "Innovation Thérapeutique"



FLUOPEPIT


sandrine.ongeri@universite-paris-saclay.fr


0180006401

HM1- 1er étage - 1612


Permanent


https://orcid.org/0000-0002-2118-7324


Actual Area of Research


PEPTIDOMIMETICS INHIBITORS OF PROTEIN/PROTEIN INTERACTIONS INVOLVING ß-SHEETS

Amyloid proteins aggregation inhibition. ß amyloide peptide, Synuclein, protein tau : Interest in Neurodegenerative diseases. IAPP : interest in type II Diabetes.

Design of peptidomimetic aggregation inhibitors, synthesis, biophysicochemical evaluation (NMR, Fluorescence, EC, CD, SPR, TEM, IMS-MS, 19F NMR …), molecular modelling.

FLUORINATED AMINO ACIDS and PEPTIDES, METHODOLOGY OF SYNTHESIS : trifluoromethylated beta-aminoacides, acyclic, cyclopropanes, aminoaziridines, triazoles…



Various Activities


Since 2010 Co-DIRECTION (with Dr. B. Crousse) of the team FLUOPEPIT OF BIOCIS. https://www.biocis.universite-paris-saclay.fr/?-Molecules-fluorees-et-peptides-d-&lang=en. 2 Full Prof, 1 DR CNRS, 3 MCU, 1 IE, PhDs (5-10), Masters (2-3).

Since 2015 Deputy director of the Doctoral school “Therapeutic innovation” ED569. 300 PhD students. Organization of their multidisciplinary training (scientific and transferable skills). Recruitment management. Conflict management between PhD students and their supervisor. In charge of the International relations and programmes.

National Academic Collaborations (UMR 8612/UPSaclay, UMR 7203/Sorbonne Univ., LCP/UPSaclay…)

International Academic Collaborations (Germany, Italy, Israel, Spain, Switzerland, USA)

National, European and international funding, in particular in HORIZON 2020 programme.

Partner of ITN « TubInTrain » : https://www.tubintrain.eu/ (2019-2023)

Partner of FETOPEN « NoPest » : https://www.h2020nopest.org/ (2019-2024) https://eugloh-network.pageflow.io/no-pest

Industrial collaborations


Teaching Activities


Medicinal Chemistry : Students in Pharmacy, in M1 and M2 Master in Pharmaceutical Sciences, in L3 Biology-Chemistry (Faculty of Pharmacy and UFR Orsay)

Peptide Chemistry : M1 Master Students in Chemistry (UFR Orsay)
























36 documents







Articles dans une revue34 document




    

  • Thierry Milcent, Pascal Retailleau, Benoit Crousse, Sandrine Ongeri. Synthesis of extended fluorinated tripeptides based on the tetrahydropyridazine scaffold. Beilstein Journal of Organic Chemistry, 2024, 20, pp.3174-3181. ⟨10.3762/bjoc.20.262⟩. ⟨hal-05142142⟩
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  • Dimitra Kyrko, Murat Saraç, Jing Hao, Pascal Retailleau, Sandrine Ongeri, et al.. Functionalized α‐Fluorinated Amines from Imines and Enol Ethers. Advanced Synthesis and Catalysis, 2024, 366 (16), pp.3460-3465. ⟨10.1002/adsc.202400517⟩. ⟨hal-04756974⟩
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  • José Laxio Arenas, Jacopo Lesma, Tap Ha‐duong, Bikash Ranjan Sahoo, Ayyalusamy Ramamoorthy, et al.. Composition and Conformation of Hetero‐ versus Homo‐Fluorinated Triazolamers Influence their Activity on Islet Amyloid Polypeptide Aggregation. Chemistry - A European Journal, 2024, 30 (28), pp.e202303887. ⟨10.1002/chem.202303887⟩. ⟨hal-04756674⟩
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  • Chloé Cayrou, Astrid Walrant, Delphine Ravault, Karine Guitot, Sylvie Noinville, et al.. Incorporation of CF 3 -pseudoprolines into polyproline type II foldamers confers promising biophysical features. Chemical Communications, In press, ⟨10.1039/D4CC02895C⟩. ⟨hal-04660873⟩
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  • Chenghui Shi, Julia Kaffy, Tâp Ha-Duong, Jean-François Gallard, Alain Pruvost, et al.. Proteolytically Stable Diaza-Peptide Foldamers Mimic Helical Hot Spots of Protein–Protein Interactions and Act as Natural Chaperones. Journal of Medicinal Chemistry, 2023, 66 (17), pp.12005-12017. ⟨10.1021/acs.jmedchem.3c00611⟩. ⟨hal-04458911⟩
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  • Chenghui Shi, Isabelle Correia, Nicolo Tonali, Sandrine Ongeri, Olivier Lequin. Two consecutive aza-amino acids in peptides promote stable β-turn formation in water. Organic & Biomolecular Chemistry, 2022, 20 (43), pp.8430-8437. ⟨10.1039/d2ob01225a⟩. ⟨hal-03955106⟩
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  • Lizeth Bodero, Karine Guitot, Nathalie Lensen, Olivier Lequin, Thierry Brigaud, et al.. Introducing the Chiral Constrained α‐Trifluoromethylalanine in Aib Foldamers to Control, Quantify and Assign the Helical Screw‐Sense**. Chemistry - A European Journal, 2022, 28 (8), pp.e202103887. ⟨10.1002/chem.202103887⟩. ⟨hal-03626224⟩
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  • José Laxio Arenas, Pascal Retailleau, Jean-Michel Gillet, Nour-Eddine Ghermani, Sandrine Ongeri, et al.. 5-Fluoro-1,2,3-triazole motif in peptides and its electronic properties. Organic & Biomolecular Chemistry, 2022, 20 (43), pp.8410-8414. ⟨10.1039/D2OB01716D⟩. ⟨hal-04249450⟩
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  • Jacopo Lesma, Faustine Bizet, Corentin Berardet, Nicolo Tonali, Sara Pellegrino, et al.. β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation. Frontiers in Cell and Developmental Biology, 2021, 9, ⟨10.3389/fcell.2021.729001⟩. ⟨hal-03367992⟩
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  • José Laxio Arenas, Yaochun Xu, Thierry Milcent, Carine van Heijenoort, Francois Giraud, et al.. Fluorinated Triazole Foldamers: folded or extended conformational preferences. ChemPlusChem, 2021, ⟨10.1002/cplu.202000791⟩. ⟨hal-03796604⟩
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  • Julia Kaffy, Corentin Berardet, Loïc Mathieu, Baptiste Legrand, Myriam Taverna, et al.. Helical γ‐Peptide Foldamers as Dual Inhibitors of Amyloid‐β Peptide and Islet Amyloid Polypeptide Oligomerization and Fibrillization. Chemistry - A European Journal, 2020, 26 (64), pp.14612-14622. ⟨10.1002/chem.202001716⟩. ⟨hal-03011765⟩
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  • Nicolo Tonali, Isabelle Correia, Jacopo Lesma, Guillaume Bernadat, Sandrine Ongeri, et al.. Introducing sequential aza--amino acids units induces repeated β--turns and helical conformations in peptides. Organic & Biomolecular Chemistry, 2020, 18, pp.3452-3458. ⟨10.1039/c9ob02654a⟩. ⟨hal-02888753⟩
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  • Corentin Berardet, Julia Kaffy, Frédéric Halgand, Guillaume van Der Rest, Sandrine Ongeri, et al.. Evidence for different in vitro oligomerization behaviors of synthetic hIAPP obtained from different sources. Analytical and Bioanalytical Chemistry, 2020, 412 (13), pp.3103-3111. ⟨10.1007/s00216-020-02560-5⟩. ⟨hal-03011853⟩
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  • Corentin Berardet, Julia Kaffy, Sandrine Ongeri, Myriam Taverna. A capillary zone electrophoresis method to investigate the oligomerization of the human Islet Amyloid Polypeptide involved in Type 2 Diabetes. Journal of Chromatography A, 2018, 1578, pp.83-90. ⟨10.1016/j.chroma.2018.10.006⟩. ⟨hal-04305493⟩
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  • Faustine Bizet, Nicolo Tonali, Jean-Louis Soulier, Agostino Oliva, Julia Kaffy, et al.. Towards a general synthesis of di-aza-amino acids containing peptides. New Journal of Chemistry, 2018, 42 (20), pp.17062-17072. ⟨10.1039/c8nj03635g⟩. ⟨hal-02347605⟩
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  • Benoît Crousse, Pascal Retailleau, Thierry Milcent, Sandrine Ongeri, Vadim A. Soloshonok. Synthesis of Trifluoromethylated Pyrrolidine and Piperidine Amino Acids. SYNFACTS, 2018, 14 (10), pp.1015. ⟨10.1055/s-0037-1610969⟩. ⟨hal-02347510⟩
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  • Jing Hao, Thierry Milcent, Pascal Retailleau, Vadim Soloshonok, Sandrine Ongeri, et al.. Asymmetric Synthesis of Cyclic Fluorinated Amino Acids. European Journal of Organic Chemistry, 2018, 2018 (27-28), pp.3688-3692. ⟨10.1002/ejoc.201800255⟩. ⟨hal-02347674⟩
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  • Nicolo Tonali, Julia Kaffy, Jean-Louis Soulier, Maria Luisa Gelmi, Emanuela Erba, et al.. Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation. European Journal of Medicinal Chemistry, 2018, 154, pp.280-293. ⟨10.1016/j.ejmech.2018.05.018⟩. ⟨hal-04305545⟩
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  • Nicolo Tonali, Julia Kaffy, Jean-Louis Soulier, Maria Luisa Gelmi, Emanuela Erba, et al.. Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation. European Journal of Medicinal Chemistry, 2018, 154, pp.280-293. ⟨10.1016/j.ejmech.2018.05.018⟩. ⟨hal-02392954⟩
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  • Yaochun Xu, Isabelle Correia, Tap Ha-Duong, Nadjib Kihal, Jean-Louis Soulier, et al.. The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands. Beilstein Journal of Organic Chemistry, 2017, 13, pp.2842 - 2853. ⟨10.3762/bjoc.13.276⟩. ⟨hal-01700974⟩
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  • Leïla Vahdati, Julia Kaffy, Dimitri Brinet, Guillaume Bernadat, Isabelle Correia, et al.. Synthesis and Characterization of Hairpin Mimics that Modulate the Early Oligomerization and Fibrillization of Amyloid β-Peptide. European Journal of Organic Chemistry, 2017, 2017 (20), pp.2971-2980. ⟨10.1002/ejoc.201700010⟩. ⟨hal-02467878⟩
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  • M. Mamone, R. Gonçalves, Fabian Blanchard, G. Bernadat, S. Ongeri, et al.. N-Difluoromethyl-triazole as a constrained scaffold in peptidomimetics. Chemical Communications, 2017, 53 (36), pp.5024-5027. ⟨10.1039/c7cc01298e⟩. ⟨hal-02998189⟩
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  • Julia Kaffy, Dimitri Brinet, Jean-Louis Soulier, Isabelle Correia, Nicolo Tonali, et al.. Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability. Journal of Medicinal Chemistry, 2016, 59 (5), pp.2025-2040. ⟨10.1021/acs.jmedchem.5b01629⟩. ⟨hal-02467871⟩
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  • Leila Vahdati, Roberto Fanelli, Guillaume Bernadat, Isabelle Correia, Olivier Lequin, et al.. Synthesis and conformational studies of a stable peptidomimetic beta-hairpin based on a bifunctional diketopiperazine turn inducer. New Journal of Chemistry, 2015, 39 (5), pp.3250-3258. ⟨10.1039/c4nj01437e⟩. ⟨hal-01366397⟩
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  • Julia Kaffy, Dimitri Brinet, Jean-Louis Soulier, Lucie Khemtémourian, Olivier Lequin, et al.. Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization.. European Journal of Medicinal Chemistry, 2014, 86C, pp.752-758. ⟨10.1016/j.ejmech.2014.09.031⟩. ⟨hal-01067196⟩
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  • Massaba Keita, Rocco de Bona, Mickaël dos Santos, Olivier Lequin, Sandrine Ongeri, et al.. Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives. Tetrahedron, 2013, 69 (15), pp.3308-3315. ⟨10.1016/j.tet.2013.02.012⟩. ⟨hal-01366842⟩
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  • Laure Dufau, Ana Sofia Marques Ressurreicao, Roberto Fanelli, Nadjib Kihal, Anamaria Vidu, et al.. Carbonylhydrazide-Based Molecular Tongs Inhibit Wild-Type and Mutated HIV-1 Protease Dimerization. Journal of Medicinal Chemistry, 2012, 55 (15), pp.6762-6775. ⟨10.1021/jm300181j⟩. ⟨hal-01544073⟩
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  • Bertrand Dorgeret, Lucie Khemtémourian, Isabelle Correia, Jean-Louis Soulier, Olivier Lequin, et al.. Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation. European Journal of Medicinal Chemistry, 2011, 46 (12), pp.5959-5969. ⟨10.1016/j.ejmech.2011.10.008⟩. ⟨hal-02467773⟩
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  • Bertrand Dorgeret, Lucie Khemtémourian, Isabelle Correia, Jean-Louis Soulier, Olivier Lequin, et al.. Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation.. European Journal of Medicinal Chemistry, 2011, 46 ((12)), pp.5959-69. ⟨10.1016/j.ejmech.2011.10.008⟩. ⟨hal-00692384⟩
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  • Erika Bourguet, Isabelle Correia, Bertrand Dorgeret, Gérard Chassaing, Sames Sicsic, et al.. Synthesis and conformational studies of pseudopeptides containing an unsymmetrical triazine scaffold. Journal of Peptide Science, 2008, 14 (5), pp.596-609. ⟨10.1002/psc.944⟩. ⟨hal-02465291⟩
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  • Ludovic Bannwarth, Thierry Rose, Silvia Frutos, Ernest Giralt, Régis Vanderesse, et al.. Peptidomimetic dimerization inhibitors of HIV-1 protease : further insights into structural and mechanism of action.. Antiviral Research, 2007, 74 (3), pp.A64. ⟨10.1016/j.antiviral.2007.01.098⟩. ⟨hal-00199087⟩
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  • David J Aitken, Alberto Albinati, Arnaud Gautier, Henri-Philippe Husson, Georges Morgant, et al.. Platinum(II) and palladium(II) complexes with N-aminoguanidine. European Journal of Inorganic Chemistry, 2007, pp.3327-3334. ⟨hal-00165303⟩
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  • Jean-Louis Soulier, Olivier Russo, Mireille Giner, Lucie Rivail, Magali Berthouze, et al.. Design and Synthesis of Specific Probes for Human 5-HT 4 Receptor Dimerization Studies. Journal of Medicinal Chemistry, 2005, 48 (20), pp.6220-6228. ⟨10.1021/jm050234z⟩. ⟨hal-03161404⟩
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  • Naïma Merabet, Julien Dumond, Bruno Collinet, Laurence van Baelinghem, Nicole Boggetto, et al.. New Constrained “Molecular Tongs” Designed To Dissociate HIV-1 Protease Dimer. Journal of Medicinal Chemistry, 2004, 47 (25), pp.6392-6400. ⟨10.1021/jm040833q⟩. ⟨hal-05022397⟩
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Pré-publications, Documents de travail2 document




    

  • Davide Di Lorenzo, Nicolo Bisi, Julia Kaffy, Lisa Marie Ramirez, Markus Zweckstetter, et al.. Synthetic chaperone based on Hsp90-Tau interaction inhibits pathological Tau aggregation and rescues physiological Tau-Microtubule interaction. 2025. ⟨hal-05047264⟩
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  • José Laxio Arenas, Jacopo Lesma, Tap Ha-Duong, Bikash Sahoo, Ayyalusamy Ramamoorthy, et al.. Relation between conformation and activity on islet amyloid polypeptide aggregation of fluorinated foldamers based on Ndifluoromethyl-1,4-triazole amino acids. 2023. ⟨hal-04273096⟩
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Documents récupérés de l'archive ouverte HAL logo




Education/Career


    

  • Since 2011 Full Professor in Medicinal Chemistry – BioCIS UMR 8076, Faculty of Pharmacy, Univ. Paris Saclay (ex Univ. Paris Sud)
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  • 2001-2011 Associate Professor in Medicinal Chemistry – BioCIS UMR 8076, Faculty of Pharmacy, Univ. Paris Sud.
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  • 1999/2001 Post-Doctoral researcher. Univ Milan (Italy). Pr. C. Gennari. European Grant
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  • 1995-1999 PhD in Organic Chemistry, Univ. Paris Descartes. Pr. H-P Husson
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  • 1995/1996 Dyson-Perrins Laboratory, Oxford (UK). Pr. Sir J. E. Baldwin
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  • 1994/1995 Master Degree in Organic Chemistry Univ. Paris 5.
    
One year Research training in Pharmaceutical Company (SERVIER Laboratories).
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  • 1989-1995 Pharmacy Degree, Faculty of Pharmacy – Univ. Paris 5
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