Julia KAFFY 

Maîtresse de Conférences 



FLUOPEPIT, Permanent


julia.kaffy@universite-paris-saclay.fr


0180006382

HM1- 1er étage - 1616


https://orcid.org/0000-0002-1725-9268
























18 documents







Articles dans une revue16 document




    

  • Dimitra Kyrko, Tingting Cao, Pascal Retailleau, Julia Kaffy, Benoît Crousse. Access to N -Fluorinated Azapeptides and Azapeptoids as Peptidomimetic Scaffolds. ACS Organic & Inorganic Au, 2025, ⟨10.1021/acsorginorgau.5c00073⟩. ⟨hal-05248269⟩
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  • José Laxio Arenas, Jacopo Lesma, Tap Ha‐duong, Bikash Ranjan Sahoo, Ayyalusamy Ramamoorthy, et al.. Composition and Conformation of Hetero‐ versus Homo‐Fluorinated Triazolamers Influence their Activity on Islet Amyloid Polypeptide Aggregation. Chemistry - A European Journal, 2024, 30 (28), pp.e202303887. ⟨10.1002/chem.202303887⟩. ⟨hal-04756674⟩
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  • Lidia Ciccone, Caterina Camodeca, Nicolò Tonali, Lucia Barlettani, Armando Rossello, et al.. New Hybrid Compounds Incorporating Natural Products as Multifunctional Agents against Alzheimer’s Disease. Pharmaceutics, 2023, 15 (10), pp.2369. ⟨10.3390/pharmaceutics15102369⟩. ⟨hal-04456200⟩
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  • Chenghui Shi, Julia Kaffy, Tâp Ha-Duong, Jean-François Gallard, Alain Pruvost, et al.. Proteolytically Stable Diaza-Peptide Foldamers Mimic Helical Hot Spots of Protein–Protein Interactions and Act as Natural Chaperones. Journal of Medicinal Chemistry, 2023, 66 (17), pp.12005-12017. ⟨10.1021/acs.jmedchem.3c00611⟩. ⟨hal-04458911⟩
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  • Jacopo Lesma, Faustine Bizet, Corentin Berardet, Nicolo Tonali, Sara Pellegrino, et al.. β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation. Frontiers in Cell and Developmental Biology, 2021, 9, ⟨10.3389/fcell.2021.729001⟩. ⟨hal-03367992⟩
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  • Julia Kaffy, Corentin Berardet, Loïc Mathieu, Baptiste Legrand, Myriam Taverna, et al.. Helical γ‐Peptide Foldamers as Dual Inhibitors of Amyloid‐β Peptide and Islet Amyloid Polypeptide Oligomerization and Fibrillization. Chemistry - A European Journal, 2020, 26 (64), pp.14612-14622. ⟨10.1002/chem.202001716⟩. ⟨hal-03011765⟩
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  • Corentin Berardet, Julia Kaffy, Frédéric Halgand, Guillaume van Der Rest, Sandrine Ongeri, et al.. Evidence for different in vitro oligomerization behaviors of synthetic hIAPP obtained from different sources. Analytical and Bioanalytical Chemistry, 2020, 412 (13), pp.3103-3111. ⟨10.1007/s00216-020-02560-5⟩. ⟨hal-03011853⟩
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  • Corentin Berardet, Julia Kaffy, Sandrine Ongeri, Myriam Taverna. A capillary zone electrophoresis method to investigate the oligomerization of the human Islet Amyloid Polypeptide involved in Type 2 Diabetes. Journal of Chromatography A, 2018, 1578, pp.83-90. ⟨10.1016/j.chroma.2018.10.006⟩. ⟨hal-04305493⟩
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  • Faustine Bizet, Nicolo Tonali, Jean-Louis Soulier, Agostino Oliva, Julia Kaffy, et al.. Towards a general synthesis of di-aza-amino acids containing peptides. New Journal of Chemistry, 2018, 42 (20), pp.17062-17072. ⟨10.1039/c8nj03635g⟩. ⟨hal-02347605⟩
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  • Nicolo Tonali, Julia Kaffy, Jean-Louis Soulier, Maria Luisa Gelmi, Emanuela Erba, et al.. Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation. European Journal of Medicinal Chemistry, 2018, 154, pp.280-293. ⟨10.1016/j.ejmech.2018.05.018⟩. ⟨hal-04305545⟩
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  • Nicolo Tonali, Julia Kaffy, Jean-Louis Soulier, Maria Luisa Gelmi, Emanuela Erba, et al.. Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation. European Journal of Medicinal Chemistry, 2018, 154, pp.280-293. ⟨10.1016/j.ejmech.2018.05.018⟩. ⟨hal-02392954⟩
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  • Yaochun Xu, Isabelle Correia, Tap Ha-Duong, Nadjib Kihal, Jean-Louis Soulier, et al.. The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands. Beilstein Journal of Organic Chemistry, 2017, 13, pp.2842 - 2853. ⟨10.3762/bjoc.13.276⟩. ⟨hal-01700974⟩
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  • Leïla Vahdati, Julia Kaffy, Dimitri Brinet, Guillaume Bernadat, Isabelle Correia, et al.. Synthesis and Characterization of Hairpin Mimics that Modulate the Early Oligomerization and Fibrillization of Amyloid β-Peptide. European Journal of Organic Chemistry, 2017, 2017 (20), pp.2971-2980. ⟨10.1002/ejoc.201700010⟩. ⟨hal-02467878⟩
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  • Julia Kaffy, Dimitri Brinet, Jean-Louis Soulier, Isabelle Correia, Nicolo Tonali, et al.. Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability. Journal of Medicinal Chemistry, 2016, 59 (5), pp.2025-2040. ⟨10.1021/acs.jmedchem.5b01629⟩. ⟨hal-02467871⟩
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  • Julia Kaffy, Dimitri Brinet, Jean-Louis Soulier, Lucie Khemtémourian, Olivier Lequin, et al.. Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization.. European Journal of Medicinal Chemistry, 2014, 86C, pp.752-758. ⟨10.1016/j.ejmech.2014.09.031⟩. ⟨hal-01067196⟩
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  • Nancy Ty, Julia Kaffy, Alban Arrault, Sylviane Thoret, Renée Pontikis, et al.. Synthesis and biological evaluation of cis-locked vinylogous combretastatin-A4 analogues: derivatives with a cyclopropyl-vinyl or a cyclopropyl-amide bridge.. Bioorganic and Medicinal Chemistry Letters, 2009, 19 (5), pp.1318-22. ⟨10.1016/j.bmcl.2009.01.062⟩. ⟨hal-00371153⟩
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Pré-publications, Documents de travail2 document




    

  • Davide Di Lorenzo, Nicolo Bisi, Julia Kaffy, Lisa Marie Ramirez, Markus Zweckstetter, et al.. Synthetic chaperone based on Hsp90-Tau interaction inhibits pathological Tau aggregation and rescues physiological Tau-Microtubule interaction. 2025. ⟨hal-05047264⟩
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  • José Laxio Arenas, Jacopo Lesma, Tap Ha-Duong, Bikash Sahoo, Ayyalusamy Ramamoorthy, et al.. Relation between conformation and activity on islet amyloid polypeptide aggregation of fluorinated foldamers based on Ndifluoromethyl-1,4-triazole amino acids. 2023. ⟨hal-04273096⟩
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Ingénieur chimiste de l’ESPCI (Ecole Supérieure de Physique et de chimie Industrielles) depuis 2001, elle obtient son doctorat en 2005 sous la direction du Dr Claude MONNERET (Institut Curie, Paris). Elle rejoint ensuite l’équipe du Dr Charles MIOSKOWSKI (CEA, Saclay) pour un stage post-doctoral de 15 mois puis celle du Pr Sylviane GIORGI-RENAULT (Université Paris 5, Faculté de Pharmacie, Paris) en tant qu’ATER en Chimie Thérapeutique. Depuis l’automne 2007, elle occupe un poste de Maître de Conférences en Chimie Thérapeutique et travaille sur l’angiogenèse tumorale ; concevant et synthétisant des inhibiteurs de méthionine aminopeptidase 2, en tant qu’agents anti-angiogéniques. Depuis 2010, elle s’intéresse à la caractérisation des interactions protéine-protéine et protéine-ligand par différentes méthodes biophysicochimiques (RMN, fluorescence, SPR, TEM …). Dans le contexte de la maladie d’Alzheimer, elle synthétise et réalise les évaluations biologiques de composés peptidomimétiques conçus au laboratoire pour moduler la cinétique d’agrégation du peptide amyloïde 1-42. Elle est aussi impliquée dans un projet de cancérologie, étudiant les interactions protéasome-inhibiteurs par fluorescence et RMN 19F.