Abdallah HAMZE 

Professeur

Responsable équipe CoSMIT



CoSMIT, Permanent


abdallah.hamze@universite-paris-saclay.fr


0180006377

HM1- 1er étage - 1510


https://orcid.org/0000-0001-8425-1971


Highlights


    

  • Synthetic methodology, including organometallic chemistry (Pd, Pt, Sn, Si, B)
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  • New catalytic reactions for C-C, and C-N bond reactions
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  • Medicinal chemistry (cancer, malaria, bioconjugate…)
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18 documents







Articles dans une revue18 document




    

  • Jun Yan, Pascal Retailleau, Abdallah Hamze, Christine Tran. Copper‐Catalyzed Domino Synthesis of Spiropyrazoline Oxindoles via Condensation of Indolin‐2‐One and Phenylhydrazine Derivatives. Advanced Synthesis and Catalysis, 2025, 367 (10), ⟨10.1002/adsc.202500223⟩. ⟨hal-05127035⟩
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  • Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, et al.. Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers. ChemBioChem, 2024, ⟨10.1002/cbic.202400062⟩. ⟨hal-04569859⟩
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  • Sarah Ducellier, Mélanie Demeules, Boris Letribot, Massimiliano Gaetani, Chloé Michaudel, et al.. Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cells. Journal for Immunotherapy of Cancer, 2024, 12 (4), pp.e007588. ⟨10.1136/jitc-2023-007588⟩. ⟨hal-05154786⟩
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  • Xinya Liu, Olivier Provot, Remi Franco, Pascal Retailleau, Mouad Alami, et al.. Synthesis of Aza‐Heterocyclic Compounds with N ‐Tosylhydrazones: Formation of Bi‐Indoles via Reductive Molybdenum Catalysis. Advanced Synthesis and Catalysis, 2023, 365 (18), pp.3155-3161. ⟨10.1002/adsc.202300613⟩. ⟨hal-04403976⟩
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  • Xinya Liu, Jean-Luc Pozzo, Abdallah Hamze, Mouad Alami, Olivier Provot. Hydration of Unsymmetrical Internal Alkynes: Factors Governing the Regioselectivity. ACS Catalysis, In press, pp.10115-10136. ⟨10.1021/acscatal.9b00482⟩. ⟨hal-04167995⟩
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  • Jun Yan, Christine Tran, Pascal Retailleau, Mouad Alami, Abdallah Hamze. Catalyst-Free Synthesis of Functionalized 4-Substituted-4 H -Benzo[ d ][1,3]oxazines via Intramolecular Cyclization of ortho- Amide- N -tosylhydrazones. Journal of Organic Chemistry, 2023, 88 (13), pp.8636-8642. ⟨10.1021/acs.joc.3c00534⟩. ⟨hal-04403982⟩
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  • Jun Yan, Christine Tran, Jérôme Bignon, Olivier Provot, Abdallah Hamze. Synthesis of Dihydro‐5 H ‐Benzo[ c ]‐Fluorenes, Dihydroindeno[ c ]‐Chromenes and Thiochromenes via Intramolecular Cyclization and their Effect on Human Leukemia Cells. Advanced Synthesis and Catalysis, 2022, 364 (9), pp.1613-1619. ⟨10.1002/adsc.202200153⟩. ⟨hal-04170276⟩
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  • Romain Hany, Jean-Philippe Leyris, Guillaume Bret, Sylvie Mallié, Chamroeun Sar, et al.. High-throughput screening for extracellular inhibitors of the FLT3 receptor tyrosine kinase reveals chemically diverse and druggable negative allosteric modulators. ACS Chemical Biology, 2022, 17 (3), pp.709-722. ⟨10.1021/acschembio.2c00048⟩. ⟨hal-03747971⟩
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  • Yunxin Yao, Guangkuan Zhao, Abdallah Hamze, Mouad Alami, Olivier Provot. Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN. European Journal of Organic Chemistry, 2022, 2022 (7), pp.5775-5779. ⟨10.1002/ejoc.202101460⟩. ⟨hal-04279896⟩
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  • Camille Hauguel, Sarah Ducellier, Olivier Provot, Nada Ibrahim, Diana Lamaa, et al.. Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. European Journal of Medicinal Chemistry, 2022, 240, pp.114573. ⟨10.1016/j.ejmech.2022.114573⟩. ⟨hal-03752715⟩
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  • Christine Tran, Aïcha Abdallah, Valentin Duchemann, Guillaume Lefèvre, Abdallah Hamze. Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations. Chinese Chemical Letters, In press, ⟨10.1016/j.cclet.2022.107758⟩. ⟨hal-03856585⟩
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  • Shannon Pecnard, Abdallah Hamze, Jérome Bignon, Bastien Prost, Alain Deroussent, et al.. Anticancer Properties of Indole Derivatives as IsoCombretastatin A-4 analogues. European Journal of Medicinal Chemistry, 2021, 223, pp.113656. ⟨10.1016/j.ejmech.2021.113656⟩. ⟨hal-03349143⟩
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  • Diana Lamaa, Camille Hauguel, Hsin-Ping Lin, Estelle Messe, Vincent Gandon, et al.. Sequential One-Pot Synthesis of 3-Arylbenzofurans from N -Tosylhydrazones and Bromophenol Derivatives. Journal of Organic Chemistry, 2020, 85 (21), pp.13664-13673. ⟨10.1021/acs.joc.0c01835⟩. ⟨hal-04477972⟩
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  • Nada Ibrahim, Pascal Bonnet, Jean-Daniel Brion, Jean-François Peyrat, Jerome Bignon, et al.. Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency. European Journal of Medicinal Chemistry, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩. ⟨hal-03036489⟩
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  • Yunxin Yao, Guangkuan Zhao, Abdallah Hamze, Mouad Alami, Olivier Provot. Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN. European Journal of Organic Chemistry, In press, ⟨10.1002/ejoc.202000979⟩. ⟨hal-02910296⟩
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  • Youness Touati‐jallabe, Thibault Tintillier, Elodie Mauchauffée, Jean-Luc Boucher, Jérémy Leroy, et al.. Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors. ChemMedChem, 2020, 15 (6), pp.517-531. ⟨10.1002/cmdc.201900659⟩. ⟨hal-02964490⟩
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  • Alexandra Bordes, Isabelle Opalinski, Fabien Thoreau, Olivier Provot, Mouad Alami, et al.. β-Glucuronidase-Responsive Albumin-Binding Prodrug of Colchicine-Site Binders for Selective cancer Therapy. ChemMedChem, 2020, ⟨10.1002/cmdc.202400969⟩. ⟨hal-04918349⟩
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  • Marie Lawson, Jordi Rodrigo, Blandine Baratte, Thomas Robert, Claire Delehouzé, et al.. Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2- a ]pyridines derivatives as protein kinase inhibitors. European Journal of Medicinal Chemistry, 2016, 123, pp.105 - 114. ⟨10.1016/j.ejmech.2016.07.040⟩. ⟨hal-03875851⟩
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Abdallah Hamze earned his Ph.D. in Organic and Medicinal Chemistry in 2003 from the University of Montpellier-France, under the supervision of Pr. J. Martinez and Dr. J. F. Hernandez. He pursued his Post-doctoral research fellowship from Sanofi in the Pr. H. Vial and Pr M. Calas research group, focusing on synthesizing new antimalarial prodrugs from 2003 to 2004. In 2006, He joined the Department of Medicinal and Organometallic Chemistry at the University of Paris Saclay as an Associate Professor and obtained his Habilitation diploma in 2011. In 2016, he received the National Scientific Qualification as an Associate Professor in Medicinal Chemistry. Professor Hamze has published more than 110 research papers in peer-reviewed journals and presented his results at numerous scientific meetings. Since 2017, he has been promoted to the rank of full Professor of Medicinal Chemistry at the University of Paris Saclay. Professor Hamze’s research program is funded by several granting agencies including the ANR, Ligue contre le Cancer, ARC, and SATT Paris Saclay.