FIGADÈRE

Flavio Alvarez, Florence Larrous, Ariel Mechaly, Benjamin Bardiaux, Quentin Goor, et al.. HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2. Scientific Reports, In press, Online ahead of print. ⟨10.1038/s41598-025-31755-y⟩. ⟨hal-05449164⟩
Martine Lapalus, Elodie Mareux, Rachida Amzal, Emmanuelle Drège, Yosra Riahi, et al.. Correction of a Traffic-Defective Missense ABCB11 Variant Responsible for Progressive Familial Intrahepatic Cholestasis Type 2. International Journal of Molecular Sciences, 2025, 26 (11), pp.5232. ⟨10.3390/ijms26115232⟩. ⟨hal-05293002⟩
Bastien Champciaux, Nicolas Jamey, Bruno Figadère, Laurent Ferrié. Peroxycarbenium-Mediated Asymmetric Synthesis of 1,2-Dioxanes and 1,2-Dioxolanes. Journal of the American Chemical Society, 2025, 147 (4), pp.3353-3359. ⟨10.1021/jacs.4c13899⟩. ⟨hal-04918894⟩
Thaís Antonia Alves Fernandes, Aurore Tourville, Ismaila Ciss, Rafaela Ribeiro Silva, Bianca Andretto de Mattos, et al.. Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage. Neurotoxicity Research, 2025, 43 (2), pp.16. ⟨10.1007/s12640-025-00742-6⟩. ⟨hal-05190872⟩
Bianca Andretto de Mattos, Rodrigo Hernán Tomas-Grau, Thaís Antonia Alves Fernandes, Florencia González-Lizárraga, Aurore Tourville, et al.. Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative. Biomolecules, 2025, 15 (7), pp.941. ⟨10.3390/biom15070941⟩. ⟨hal-05346486⟩
Eric Konofal, Michel Lecendreux, Jean-Charles Bizot, Anh-Tuan Lormier, Bruno Figadère. NLS-3 (Levophacetoperane or (R,R) Phacetoperane): A Reverse Ester of Methylphenidate: A Literature Review. Current Medicinal Chemistry, 2024, 31 (9), pp.1069-1081. ⟨10.2174/0929867330666230120161837⟩. ⟨hal-04284826⟩
Ismaila Ciss, Matar M Seck, Bruno Figadère, Laurent Ferrié. Advances Toward Amphidinolides C, F and U: Isolations, Synthetic Studies and Total Syntheses. Chemistry - A European Journal, 2024, 30 (27), pp.e202400471. ⟨10.1002/chem.202400471⟩. ⟨hal-04738667⟩
Glauce Nascimento, Airam Vivanco-Estela, Laurent Ferrié, Bruno Figadere, Rita Raisman-Vozari, et al.. Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation. European Journal of Pharmacology, 2024, 984, pp.177054. ⟨10.1016/j.ejphar.2024.177054⟩. ⟨hal-05346662⟩
Philippe Loiseau, Kaluvu Balaraman, Gillian Barratt, Sébastien Pomel, Rémy Durand, et al.. The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates. Molecules, 2022, 27 (7), pp.2313. ⟨10.3390/molecules27072313⟩. ⟨hal-05149192⟩
Laura Vila, Nuria Cabedo, Carlos Villarroel-Vicente, Ainhoa García, Álvaro Bernabeu, et al.. Synthesis and biological studies of "Polycerasoidol" and "trans-δ-Tocotrienolic acid" derivatives as PPARα and/or PPARγ agonists. Bioorganic and Medicinal Chemistry, 2022, 53, pp.116532. ⟨10.1016/j.bmc.2021.116532⟩. ⟨hal-03463394⟩
Laurent Ferrié, Ismaila Ciss, Johan Fenneteau, Sara Vallerotto, Matar Seck, et al.. Amphidinolides F and C2: An Odyssey in Total Synthesis. Journal of Organic Chemistry, 2022, 87 (2), pp.1110-1123. ⟨10.1021/acs.joc.1c02458⟩. ⟨hal-03775625⟩
Valeria Parrales-Macias, Abha Harfouche, Laurent Ferrié, Stéphane Haïk, Patrick Michel, et al.. Effects of a New Natural Catechol-O-methyl Transferase Inhibitor on Two In Vivo Models of Parkinson’s Disease. ACS Chemical Neuroscience, 2022, 13 (23), pp.3303-3313. ⟨10.1021/acschemneuro.2c00356⟩. ⟨hal-04869527⟩
Ainhoa García, Laura Vila, Paloma Marín, Álvaro Bernabeu, Carlos Villarroel-Vicente, et al.. Synthesis of 2-Prenylated Alkoxylated Benzopyrans by Horner-Wadsworth-Emmons olefination with PPARα/γ Agonist Activity. ACS Medicinal Chemistry Letters, 2021, ⟨10.1021/acsmedchemlett.1c00400⟩. ⟨hal-03373981⟩
Nilson Carlos Ferreira Junior, Maurício dos Santos Pereira, Nour Francis, Paola Ramirez, Paula Martorell, et al.. The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress. Cells, 2021, 10 (8), pp.2163. ⟨10.3390/cells10082163⟩. ⟨hal-03351250⟩
María Martín López, Nicolas Jamey, Alexis Pinet, Bruno Figadère, Laurent Ferrié. Oxidative Ring Expansion of Cyclobutanols: Access to Functionalized 1,2-Dioxanes. Organic Letters, 2021, 23 (5), pp.1626-1631. ⟨10.1021/acs.orglett.1c00070⟩. ⟨hal-03320607⟩
Pedro Vásquez-Ocmín, Alice Gadea, Sandrine Cojean, Guillaume Marti, Sébastien Pomel, et al.. Metabolomic approach of the antiprotozoal activity of medicinal Piper species used in Peruvian Amazon. Journal of Ethnopharmacology, 2021, 264, pp.113262. ⟨10.1016/j.jep.2020.113262⟩. ⟨hal-03479341⟩
Alexis Pinet, Sandrine Cojean, Linh Thuy Nguyen, Pedro Vásquez-Ocmín, Alexandre Maciuk, et al.. Anti-protozoal and anti-fungal evaluation of 3,5-disubstituted 1,2-dioxolanes. Bioorganic and Medicinal Chemistry Letters, 2021, 47, pp.128196. ⟨10.1016/j.bmcl.2021.128196⟩. ⟨hal-03320600⟩
Sergio Ortiz, Pedro G Vásquez-Ocmín, Sandrine Cojean, Chouaha Bouzidi, Sylvie Michel, et al.. Correlation study on methoxylation pattern of flavonoids and their heme-targeted antiplasmodial activity. Bioorganic Chemistry, 2020, 104, ⟨10.1016/j.bioorg.2020.104243⟩. ⟨hal-02990750⟩
Alexis Pinet, Linh T Nguyen, Bruno Figadère, Laurent Ferrié. Synthesis of 3,5-Disubstituted 1,2-Dioxolanes. European Journal of Organic Chemistry, 2020, ⟨10.1002/ejoc.202000980⟩. ⟨hal-02973067⟩
Timothée Aboua Okpekon, Faustin Aka Kabran, Venance Martial Say, Laurent Evanno, Alexandre Maciuk, et al.. Apoprunellelactone (APL), an antiprotozoal lactone from the stem barks of Isolona cooperi Hutch. & Dalziel (Annonaceae). Natural Product Research, 2020, 35 (23), pp.5112-5119. ⟨10.1080/14786419.2020.1781116⟩. ⟨hal-05115394⟩
Shawn Goyal, Beth Binnington, Stephen D S Mccarthy, Didier Desmaele, Laurent Ferrié, et al.. Inhibition of in vitro Ebola infection by anti-parasitic quinoline derivatives. F1000Research, 2020, 9, pp.268. ⟨10.12688/f1000research.22352.1⟩. ⟨hal-03009691⟩
Alexis Pinet, Bruno Figadère, Laurent Ferrié. Access to Functionalized 3,5-Disubstituted 1,2-Dioxolanes under Mild Conditions through Indium(III) Chloride/Trimethylsilyl Chloride or Scandium(III) Triflate Catalysis. Advanced Synthesis and Catalysis, 2020, 362 (5), pp.1190-1194. ⟨10.1002/adsc.201901145⟩. ⟨hal-02973069⟩
Almudena Bermejo, Isabel Barrachina, Noureddine El Aouad, Xavier Franck, Nadia Chahboune, et al.. Synthesis of benzopyran derivatives as PPARα and/ or PPARγ activators. Bioorganic and Medicinal Chemistry Letters, 2019, 27 (24), pp.115162. ⟨10.1016/j.bmc.2019.115162⟩. ⟨hal-02347291⟩
Alexis Pinet, Thuy Linh Nguyen, Guillaume Bernadat, Bruno Figadère, Laurent Ferrié. Synthesis of 3,5-Disubstituted 1,2-Dioxolanes through the Use of Acetoxy Peroxyacetals. Organic Letters, 2019, 21 (12), pp.4729-4733. ⟨10.1021/acs.orglett.9b01616⟩. ⟨hal-02271180⟩
Almudena Bermejo, Aida Collado, Isabel Barrachina, Patrice Marqués, Noureddine El Aouad, et al.. Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect. Journal of Natural Products, 2019, 82 (7), pp.1733-2066. ⟨10.1021/acs.jnatprod.9b00003⟩. ⟨hal-02173275⟩
Gianina Luca, Mojtaba Bandarabadi, Eric Konofal, Michel Lecendreux, Laurent Ferrié, et al.. Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound. Frontiers in Neuroscience, 2018, 12, ⟨10.3389/fnins.2018.00519⟩. ⟨hal-02283111⟩
Laurent Ferrié, Johan Fenneteau, Bruno Figadère. Total Synthesis of the Marine Macrolide Amphidinolide F. Organic Letters, 2018, 20 (11), pp.3192-3196. ⟨10.1021/acs.orglett.8b01020⟩. ⟨hal-02356320v2⟩
Vasanthan Ravichandran, Nalia Mekarnia, Sébastien Pomel, Sandrine Cojean, Laurent Ferrié, et al.. New Water-Soluble Polymeric Prodrugs of 2-n-propylquinoline: Synthesis and Evaluation of In Vitro and In Vivo Activities Against Leishmania donovani. Regenerative Engineering and Translational Medicine, 2018, 4 (1), pp.11-20. ⟨10.1007/s40883-018-0045-3⟩. ⟨hal-05149115⟩
Pedro Vásquez-Ocmín, Sandrine Cojean, Elsa Rengifo, Soulaf Suyyagh-Albouz, Carlos Amasifuen Guerra, et al.. Antiprotozoal activity of medicinal plants used by Iquitos-Nauta road communities in Loreto (Peru). Journal of Ethnopharmacology, 2018, 210, pp.372-385. ⟨10.1016/j.jep.2017.08.039⟩. ⟨hal-05149102⟩
Julien Legros, Bruno Figadère. Grignard Reagents and Iron. Physical Sciences Reviews, 2018, 3 (3), pp.20160020. ⟨10.1515/psr-2016-0020⟩. ⟨hal-02024513⟩
Gael Le Douaron, Laurent Ferrié, Julia E. Sepulveda-Diaz, Blandine Séon-Méniel, Rita Raisman-Vozari, et al.. Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease. ACS Chemical Neuroscience, 2017, ⟨10.1021/acschemneuro.6b00385⟩. ⟨hal-01480347⟩
Kaluvu Balaraman, Nashira Campos Vieira, Fathi Moussa, Joël Vacus, Sandrine Cojean, et al.. In vitro and in vivo antileishmanial properties of a 2-n-propylquinoline hydroxypropyl β-cyclodextrin formulation and pharmacokinetics via intravenous route. Biomedicine and Pharmacotherapy, 2015, 76, pp.127-133. ⟨10.1016/j.biopha.2015.10.028⟩. ⟨hal-05149031⟩
Gael Le Douaron, Fanny Schmidt, Majid Amar, Hanane Kadar, Lucila Debortoli, et al.. Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.. European Journal of Medicinal Chemistry, 2015, 89, pp.467-479. ⟨hal-01111037⟩
Hanane Kadar, Gael Le Douaron, Majid Amar, Laurent Ferrié, Bruno Figadère, et al.. MALDI Mass Spectrometry Imaging of 1-Methyl-4-phenylpyridinium (MPP(+)) in Mouse Brain.. Neurotoxicity Research, 2014, 25 (1), pp.135-145. ⟨10.1007/s12640-013-9449-5⟩. ⟨hal-00935375⟩
Zahra Abada, Sandrine Cojean, Sébastien Pomel, Laurent Ferrié, Bernardin Akagah, et al.. Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives. European Journal of Medicinal Chemistry, 2013, 67 (2), pp.158-165. ⟨10.1016/j.ejmech.2013.06.002⟩. ⟨hal-05148876⟩
Ch Venkateswarlu, Pv Balaji, De Kavita, Benoît Crousse, Bruno Figadère, et al.. Straightforward synthesis of 2-propylquinolines under multicomponent conditions in fluorinated alcohols. Journal of Fluorine Chemistry, 2013, pp.94-98. ⟨10.1016/j.jfluchem.2012.12.006⟩. ⟨hal-01015813⟩
Katalina Muñoz-Durango, Alexandre Maciuk, Abha Harfouche, Sandra Torijano-Gutiérrez, Jean-Christophe Jullian, et al.. Detection, Characterization, and Screening of Heme-Binding Molecules by Mass Spectrometry for Malaria Drug Discovery. Analytical Chemistry, 2012, 84 (7), pp.3324-3329. ⟨mnhn-02047391⟩
Gerardo Cebrian-Torrejon, Suzana Assad Kahn, Nathalie Lagarde, Flavia Castellano, Karine Leblanc, et al.. Antiproliferative Activity of trans-Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells. Journal of Natural Products, 2012, 75 (2), pp.257-261. ⟨10.1021/np2004165⟩. ⟨hal-01541436⟩
Gerardo Cebrian Cebrian-Torrejon, Kevin Spelman, Karine Leblanc, Katalina Muñoz-Durango, Sandra Torijano Gutierrez, et al.. The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum. Revista Brasileira de Farmacognosia, 2011, 21 (4), pp.652-661. ⟨10.1590/S0102-695X2011005000104⟩. ⟨mnhn-02867451⟩

Brevets1 document

Fanny Schmidt, Bruno Figadère, Rita. Raisman-Vozari, Pierre Champy, Xavier Franck. Heterocyclic derivatives, especially quinoxalines and quinolines, their preparation and use in the treatment of neurodegenerative diseases. France, Patent n° : WO 2010007179 A1. 2010. ⟨hal-01150302⟩

Pré-publications, Documents de travail1 document

Flavio Alvarez, Florence Larrous, Ariel Mechaly, Benjamin Bardiaux, Quentin Goor, et al.. HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2. 2025. ⟨pasteur-05261353⟩

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