Laurent FERRIÉ 

Chargé de Recherche 



Chimie des Substances Naturelles, Permanent


laurent.ferrie@universite-paris-saclay.fr


0180006368

HM1- 1er étage - 1712


https://orcid.org/0000-0002-1171-205X


Current interest of research :


TOTAL SYNTHESIS OF NATURAL PRODUCT :


– THF containing natural products :


– Structural determination :


SYNTHESIS OF ORGANIC PEROXIDES :


– Utilization of peroxycarbeniums to obtain functionalized organic peroxides :


MEDICINAL CHEMISTRY :


– Synthesis of small molecules to improve actual treatments in Parkinson disease.


– Synthesis of new anti-parasitic molecules (malaria, leishmaniosis)
























26 documents







Articles dans une revue23 document




    

  • Thaís Antonia Alves Fernandes, Aurore Tourville, Ismaila Ciss, Rafaela Ribeiro Silva, Bianca Andretto de Mattos, et al.. Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage. Neurotoxicity Research, 2025, 43 (2), pp.16. ⟨10.1007/s12640-025-00742-6⟩. ⟨hal-05190872⟩
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  • Bastien Champciaux, Nicolas Jamey, Bruno Figadère, Laurent Ferrié. Peroxycarbenium-Mediated Asymmetric Synthesis of 1,2-Dioxanes and 1,2-Dioxolanes. Journal of the American Chemical Society, 2025, 147 (4), pp.3353-3359. ⟨10.1021/jacs.4c13899⟩. ⟨hal-04918894⟩
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  • Laurent Ferrié. Les endoperoxydes, des hétérocycles singuliers. L'Actualité Chimique, 2025, 505, pp.21-27. ⟨hal-05346766⟩
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  • Bianca Andretto de Mattos, Rodrigo Hernán Tomas-Grau, Thaís Antonia Alves Fernandes, Florencia González-Lizárraga, Aurore Tourville, et al.. Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative. Biomolecules, 2025, 15 (7), pp.941. ⟨10.3390/biom15070941⟩. ⟨hal-05346486⟩
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  • Nicolas Jamey, Laurent Ferrié. Stereodivergent Total Synthesis of Ethyl Plakortide Z. Organic Letters, 2024, 26 (27), pp.5741-5745. ⟨10.1021/acs.orglett.4c01893⟩. ⟨hal-04738657⟩
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  • Clémence Rose, Rodrigo Hernán Tomas‐grau, Brenda Zabala, Patrick Pierre Michel, Jean‐michel Brunel, et al.. C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration. ChemMedChem, 2024, 19, ⟨10.1002/cmdc.202300597⟩. ⟨hal-04736533⟩
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  • Ismaila Ciss, Matar M Seck, Bruno Figadère, Laurent Ferrié. Advances Toward Amphidinolides C, F and U: Isolations, Synthetic Studies and Total Syntheses. Chemistry - A European Journal, 2024, 30 (27), pp.e202400471. ⟨10.1002/chem.202400471⟩. ⟨hal-04738667⟩
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  • Glauce Nascimento, Airam Vivanco-Estela, Laurent Ferrié, Bruno Figadere, Rita Raisman-Vozari, et al.. Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation. European Journal of Pharmacology, 2024, 984, pp.177054. ⟨10.1016/j.ejphar.2024.177054⟩. ⟨hal-05346662⟩
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  • Mansour Kerim, Laurent Evanno, Laurent Ferrié. Stereodivergent Total Syntheses of (+)-Mycaperoxides C, D, G Methyl Ester and (-)-Mycaperoxide B. Chemistry - A European Journal, 2023, 29 (6), ⟨10.1002/chem.202203004⟩. ⟨hal-04250595⟩
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  • Margot Draveny, Clémence Rose, Alexis Pinet, Laurent Ferrié, Bruno Figadère, et al.. Scope and Limitations of Exploiting the Ability of the Chemosensitizer NV716 to Enhance the Activity of Tetracycline Derivatives against Pseudomonas aeruginosa. Molecules, 2023, 28 (11), pp.4262. ⟨10.3390/molecules28114262⟩. ⟨hal-04244665⟩
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  • Rodrigo Tomas-Grau, Florencia González-Lizárraga, Diego Ploper, César Avila, Sergio Socías, et al.. Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound. Cells, 2022, 11 (17), pp.2759. ⟨10.3390/cells11172759⟩. ⟨hal-03775634⟩
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  • Laurent Ferrié, Ismaila Ciss, Johan Fenneteau, Sara Vallerotto, Matar Seck, et al.. Amphidinolides F and C2: An Odyssey in Total Synthesis. Journal of Organic Chemistry, 2022, 87 (2), pp.1110-1123. ⟨10.1021/acs.joc.1c02458⟩. ⟨hal-03775625⟩
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  • Laurent Ferrié, Ondine Picot, Amandine Guérinot, Janine Cossy. Synthesis of Spongidepsin and Analogs. European Journal of Organic Chemistry, 2020, ⟨10.1002/ejoc.202001009⟩. ⟨hal-02973074⟩
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  • Shawn Goyal, Beth Binnington, Stephen D S Mccarthy, Didier Desmaele, Laurent Ferrié, et al.. Inhibition of in vitro Ebola infection by anti-parasitic quinoline derivatives. F1000Research, 2020, 9, pp.268. ⟨10.12688/f1000research.22352.1⟩. ⟨hal-03009691⟩
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  • Alexis Pinet, Bruno Figadère, Laurent Ferrié. Access to Functionalized 3,5-Disubstituted 1,2-Dioxolanes under Mild Conditions through Indium(III) Chloride/Trimethylsilyl Chloride or Scandium(III) Triflate Catalysis. Advanced Synthesis and Catalysis, 2020, 362 (5), pp.1190-1194. ⟨10.1002/adsc.201901145⟩. ⟨hal-02973069⟩
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  • Alexis Pinet, Thuy Linh Nguyen, Guillaume Bernadat, Bruno Figadère, Laurent Ferrié. Synthesis of 3,5-Disubstituted 1,2-Dioxolanes through the Use of Acetoxy Peroxyacetals. Organic Letters, 2019, 21 (12), pp.4729-4733. ⟨10.1021/acs.orglett.9b01616⟩. ⟨hal-02271180⟩
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  • Gianina Luca, Mojtaba Bandarabadi, Eric Konofal, Michel Lecendreux, Laurent Ferrié, et al.. Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound. Frontiers in Neuroscience, 2018, 12, ⟨10.3389/fnins.2018.00519⟩. ⟨hal-02283111⟩
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  • Laurent Ferrié, Johan Fenneteau, Bruno Figadère. Total Synthesis of the Marine Macrolide Amphidinolide F. Organic Letters, 2018, 20 (11), pp.3192-3196. ⟨10.1021/acs.orglett.8b01020⟩. ⟨hal-02356320v2⟩
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  • Vasanthan Ravichandran, Nalia Mekarnia, Sébastien Pomel, Sandrine Cojean, Laurent Ferrié, et al.. New Water-Soluble Polymeric Prodrugs of 2-n-propylquinoline: Synthesis and Evaluation of In Vitro and In Vivo Activities Against Leishmania donovani. Regenerative Engineering and Translational Medicine, 2018, 4 (1), pp.11-20. ⟨10.1007/s40883-018-0045-3⟩. ⟨hal-05149115⟩
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  • Gael Le Douaron, Laurent Ferrié, Julia E. Sepulveda-Diaz, Blandine Séon-Méniel, Rita Raisman-Vozari, et al.. Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease. ACS Chemical Neuroscience, 2017, ⟨10.1021/acschemneuro.6b00385⟩. ⟨hal-01480347⟩
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  • Gael Le Douaron, Fanny Schmidt, Majid Amar, Hanane Kadar, Lucila Debortoli, et al.. Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.. European Journal of Medicinal Chemistry, 2015, 89, pp.467-479. ⟨hal-01111037⟩
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  • Hanane Kadar, Gael Le Douaron, Majid Amar, Laurent Ferrié, Bruno Figadère, et al.. MALDI Mass Spectrometry Imaging of 1-Methyl-4-phenylpyridinium (MPP(+)) in Mouse Brain.. Neurotoxicity Research, 2014, 25 (1), pp.135-145. ⟨10.1007/s12640-013-9449-5⟩. ⟨hal-00935375⟩
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  • Zahra Abada, Sandrine Cojean, Sébastien Pomel, Laurent Ferrié, Bernardin Akagah, et al.. Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives. European Journal of Medicinal Chemistry, 2013, 67 (2), pp.158-165. ⟨10.1016/j.ejmech.2013.06.002⟩. ⟨hal-05148876⟩
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Pré-publications, Documents de travail3 document




    

  • Laurent Ferrié, Bruno Figadère, Nicolas Jamey, Bastien Champciaux. Peroxy-Carbenium Mediated Asymmetric Synthesis of 1,2-Dioxanes and 1,2-Dioxolanes. 2024. ⟨hal-04757792⟩
    • 

  • Clémence Rose, Rodrigo Hernán Tomas-Grau, Brenda Zabala, Jean-Michel Brunel, Patrick Michel, et al.. Enhancing Inhibition of Both α-Synuclein Aggregation and Neuroinflammation: New Insights into the C-9 Modification of Doxycycline. 2023. ⟨hal-04250582⟩
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  • Mansour Dolé Kérim, Laurent Evanno, Laurent Ferrie. Stereodivergent Total Syntheses of (+)-Mycaperoxides C, D, G Methyl Ester and (-)-Mycaperoxide B. 2022. ⟨hal-03775643⟩
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Education


    

  • 1999-2001 : “IUT” of chemistry in Castres (Université de Toulouse –France- Institut Universitaire Technologique/ Equivalent of the HND level)
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  • 2001-2004 : leading school of science of chemistry, CPE Lyon (France).
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  • 2003-2004 : MSc in Organic Chemistry, with a distinction Université Claude Bernard Lyon I, France.
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  • 2004-2007 : PhD in Organic Chemistry under the direction of Pr. J. Cossy, ESPCI. UPMC/Sorbonne Université, Paris, France.
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Mars 2018 : Habilitation thesis (HDR), Université Paris Sud.




Professional Experience


    

  • 2008-2009 : Post-doctoral fellow, Pr. Wipf group. University of Pittsburg, Pennsylvania, USA.
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  • 2009-2013 : CNRS researcher 2nd class in BioCIS, Université Paris-Sud (France). Laboratory of Natural Substances.
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  • 2013-Today : CNRS researcher 1st class.
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