Mouad ALAMI 

Directeur de Recherche

Directeur de l'UMR 8076



CoSMIT


mouad.alami@universite-paris-saclay.fr


0180006341

HM1- 1er étage - 1804


Permanent


https://orcid.org/0000-0003-4601-462X


DR ALAMI’S FIELD OF SPECIALIZATION INCLUDE :


• THE DEVELOPMENT OF NOVEL SYNTHETIC METHODOLOGIES INVOLVING ORGANOMETALLIC CHEMISTRY : hydro and carbometallation reactions, selective C-C and C-N bonds formation in heterocyclic chemistry and polyunsaturated molecules, and the development of new multi-components reactions (MCR) towards organic synthesis,


• MEDICINAL CHEMISTRY particularly, the synthesis of structurally challenging and biologically relevant natural and non-natural products with antitumoral activity. We have a special interest in the design and synthesis of anti-mitotic agents that mediate their primary biological activity through a direct binding interaction with tubulin. Specific applications are in the discovery and development of vascular disrupting agents (VDA) for the treatment of solid tumors and ophthalmologic disorders. Additional projects include anti-angiogenic agents, novel hsp90 inhibitors, particularly those targeting C-terminal domain, as well as progesterone receptor antagonists.
























114 documents







Articles dans une revue108 document




    

  • Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, et al.. Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers. ChemBioChem, 2024, ⟨10.1002/cbic.202400062⟩. ⟨hal-04569859⟩
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  • Sarah Ducellier, Mélanie Demeules, Boris Letribot, Massimiliano Gaetani, Chloé Michaudel, et al.. Dual molecule targeting HDAC6 leads to intratumoral CD4+ cytotoxic lymphocytes recruitment through MHC-II upregulation on lung cancer cells. Journal for Immunotherapy of Cancer, 2024, 12 (4), pp.e007588. ⟨10.1136/jitc-2023-007588⟩. ⟨hal-05154786⟩
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  • Mouad Alami, Olivier Provot. Recent advances in the synthesis of dibenzofurans. Organic & Biomolecular Chemistry, 2024, 22 (7), pp.1323-1345. ⟨10.1039/D3OB01736B⟩. ⟨hal-04478438⟩
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  • Xinya Liu, Jean-Luc Pozzo, Abdallah Hamze, Mouad Alami, Olivier Provot. Hydration of Unsymmetrical Internal Alkynes: Factors Governing the Regioselectivity. ACS Catalysis, In press, pp.10115-10136. ⟨10.1021/acscatal.9b00482⟩. ⟨hal-04167995⟩
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  • Svetlana Gataullina, Gilles Galvani, Sabrina Touchet, Caroline Nous, Eric Lemaire, et al.. GluN2C selective inhibition is a target to develop new antiepileptic compounds. Epilepsia, 2022, ⟨10.1111/epi.17396⟩. ⟨hal-03760521⟩
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  • Dmytro Ryzhakov, Audrey Beillard, Franck Le Bideau, Riyadh Ahmed Atto Al‐shuaeeb, Mouad Alami, et al.. Azoliums and Ag(I)‐N‐Heterocyclic Carbene Thioglycosides: Synthesis, Reactivity and Bioactivity. European Journal of Organic Chemistry, 2022, 2022 (9), pp.e202101499. ⟨10.1002/ejoc.202101499⟩. ⟨hal-03648181v2⟩
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  • Maha Fatthalla, Nicolas Grimblat, Etienne Brachet, Mouad Alami, Vincent Gandon, et al.. Synthesis of axially chiral biaryl thioglycosides through thiosugar-directed Pd-catalyzed asymmetric C–H activation. Chemical Communications, 2021, 57 (80), pp.10355-10358. ⟨10.1039/d1cc03971g⟩. ⟨hal-03425421⟩
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  • Yunxin Yao, Mouad Alami, Abdallah Hamze, Olivier Provot. Recent Advances in the Synthesis of Pyrido[1,2-a]indoles. Organic & Biomolecular Chemistry, 2021, 19 (16), pp.3509-3526. ⟨10.1039/D1OB00153A⟩. ⟨hal-03349116⟩
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  • Romain Darrigrand, Alison Pierson, Marine Rouillon, Dolor Renko, Mathilde Boulpicante, et al.. Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens. Communications Biology, 2021, 4 (1), pp.269. ⟨10.1038/s42003-021-01801-2⟩. ⟨hal-03396797⟩
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  • Shannon Pecnard, Olivier Provot, Hélène Levaique, Jérome Bignon, Laurie Askenatzis, et al.. Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2021, 209, pp.112873. ⟨10.1016/j.ejmech.2020.112873⟩. ⟨hal-03034493⟩
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  • Shannon Pecnard, Abdallah Hamze, Jérome Bignon, Bastien Prost, Alain Deroussent, et al.. Anticancer Properties of Indole Derivatives as IsoCombretastatin A-4 analogues. European Journal of Medicinal Chemistry, 2021, 223, pp.113656. ⟨10.1016/j.ejmech.2021.113656⟩. ⟨hal-03349143⟩
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  • Juba Ghouilem, Christine Tran, Nicolas Grimblat, Pascal Retailleau, Mouad Alami, et al.. Diastereoselective Pd-Catalyzed Anomeric C(sp 3 )–H Activation: Synthesis of α-(Hetero)aryl C-Glycosides. ACS Catalysis, 2021, 11 (3), pp.1818-1826. ⟨10.1021/acscatal.0c05052⟩. ⟨hal-03324386⟩
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  • Shannon Pecnard, Abdallah Hamze, Jean-Luc Pozzo, Mouad Alami, Olivier Provot. Synthesis of Oxazino[4,3-a]indoles and Biological Applications. European Journal of Medicinal Chemistry, 2021, 224, pp.113728. ⟨10.1016/j.ejmech.2021.113728⟩. ⟨hal-03349152⟩
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  • Kena Zhang, Christine Tran, Mouad Alami, Abdallah Hamze, Olivier Provot. Synthesis and biological activities of pyrazino[1,2-a]indole and pyrazino[1,2-a]indol-1-one derivatives. Pharmaceuticals, 2021, 14 (8), pp.779. ⟨10.3390/ph14080779⟩. ⟨hal-03349178⟩
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  • Nada Ibrahim, Pascal Bonnet, Jean-Daniel Brion, Jean-François Peyrat, Jerome Bignon, et al.. Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency. European Journal of Medicinal Chemistry, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩. ⟨hal-03036489⟩
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  • Yunxin Yao, Guangkuan Zhao, Abdallah Hamze, Mouad Alami, Olivier Provot. Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN. European Journal of Organic Chemistry, In press, ⟨10.1002/ejoc.202000979⟩. ⟨hal-02910296⟩
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  • Boris Letribot, Wafa Redjdal, Belkacem Benmerad, Franck Le Bideau, Mouad Alami, et al.. Synthesis of N -Glycosyl-2-oxindoles by Pd-Catalyzed N-Arylation of 1-Amidosugars. Organic Letters, 2020, 22 (11), pp.4201-4206. ⟨10.1021/acs.orglett.0c01262⟩. ⟨hal-03009606⟩
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  • Ilhem Khelifi, Shannon Pecnard, Guillaume Bernadat, Jérôme Bignon, Hélène Levaique, et al.. Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines. ChemMedChem, 2020, ⟨10.1002/cmdc.202000197⟩. ⟨hal-02910295⟩
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  • Abdallah Hamzé, Mouad Alami, Olivier Provot. Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents. European Journal of Medicinal Chemistry, 2020, 190, pp.112110. ⟨10.1016/j.ejmech.2020.112110⟩. ⟨hal-02910294⟩
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  • Nedjwa Bennai, Nada Ibrahim, Jérôme C. Marrot, Mohamed Belkadi, Mouâd Alami, et al.. Synthesis of S-Trifluoromethyl S-Arylsulfoximine Thioglycosides through Pd-Catalyzed Migita Cross-Coupling. European Journal of Organic Chemistry, 2020, 2020 (31), pp.4972-4981. ⟨10.1002/ejoc.202000821⟩. ⟨hal-02938398⟩
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  • Mingxiang Zhu, Mouad Alami, Samir Messaoudi. Room-Temperature Pd-Catalyzed Synthesis of 1-(Hetero)aryl Selenoglycosides. Organic Letters, 2020, 22 (16), pp.6584-6589. ⟨10.1021/acs.orglett.0c02352⟩. ⟨hal-03036512⟩
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  • Alexandra Bordes, Isabelle Opalinski, Fabien Thoreau, Olivier Provot, Mouad Alami, et al.. β-Glucuronidase-Responsive Albumin-Binding Prodrug of Colchicine-Site Binders for Selective cancer Therapy. ChemMedChem, 2020, ⟨10.1002/cmdc.202400969⟩. ⟨hal-04918349⟩
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  • Mingxiang Zhu, Mouad Alami, Samir Messaoudi. Electrochemical nickel-catalyzed Migita cross-coupling of 1-thiosugars with aryl, alkenyl and alkynyl bromides. Chemical Communications, 2020, 56 (32), pp.4464-4467. ⟨10.1039/D0CC01126F⟩. ⟨hal-03036460⟩
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  • Nedjwa Bennai, Amélie Chabrier, Maha Fatthalla, Christine Tran, Expédite Yen-Pon, et al.. Reversing Reactivity: Stereoselective Desulfurative 1,2- trans-O-Glycosylation of Anomeric Thiosugars with Carboxylic Acids under Copper or Cobalt Catalysis. Journal of Organic Chemistry, 2020, 85 (14), pp.8893-8909. ⟨10.1021/acs.joc.0c00766⟩. ⟨hal-03036397⟩
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  • Guangkuan Zhao, Mingxiang Zhu, Olivier Provot, Mouad Alami, Samir Messaoudi. Synthesis of 2,3-Substituted β- N -Glycosyl Indoles through C–H Activation/Annulation Process under Rh(III)-Catalysis. Organic Letters, 2020, 22 (1), pp.57-61. ⟨10.1021/acs.orglett.9b03893⟩. ⟨hal-03036320⟩
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  • Kena Zhang, Abderrahman El Bouakher, Hélène Lévaique, Jérôme Bignon, Pascal Retailleau, et al.. Pyrrolo-imidazo[1,2- a ]pyridine Scaffolds through a Sequential Coupling of N -Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application. Journal of Organic Chemistry, 2019, 84 (21), pp.13807-13823. ⟨10.1021/acs.joc.9b02018⟩. ⟨hal-02414103⟩
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  • Tristan Verdelet, Sara Benmahdjoub, Belkacem Benmerad, Mouad Alami, Samir Messaoudi. Copper-Catalyzed Anomeric O-Arylation of Carbohydrate Derivatives at Room Temperature. Journal of Organic Chemistry, 2019, 84 (14), pp.9226-9238. ⟨10.1021/acs.joc.9b01218⟩. ⟨hal-02396654⟩
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  • Manel Hassine, Hichem Ben Jannet, Noureddine Ghermani, Mouad Alami, Samir Messaoudi. Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling. Synthesis: Journal of Synthetic Organic Chemistry, 2019, ⟨10.1055/s-0039-1690238⟩. ⟨hal-02396680⟩
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  • Mingxiang Zhu, Guillaume Dagousset, Mouad Alami, Emmanuel Magnier, Samir Messaoudi. Ni/Photoredox-Dual-Catalyzed Functionalization of 1-Thiosugars. Organic Letters, 2019, 21 (13), pp.5132-5137. ⟨10.1021/acs.orglett.9b01730⟩. ⟨hal-02396639⟩
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  • Diana Lamaa, Hsin-Ping Lin, Tourin Bzeih, Pascal Retailleau, Mouad Alami, et al.. TBAB-Catalyzed C sp 3 -N Bond Formation by Coupling Pyridotriazoles with Anilines: A New Route to (2-Pyridyl)alkylamines. European Journal of Organic Chemistry, 2019, 2019 (15), pp.2602-2611. ⟨10.1002/ejoc.201801803⟩. ⟨hal-02414091⟩
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  • Timothée Naret, Ilhem Khelifi, Olivier Provot, Jérôme Bignon, Hélène Lévaique, et al.. 1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation. Journal of Medicinal Chemistry, 2019, 62 (4), pp.1902-1916. ⟨10.1021/acs.jmedchem.8b01386⟩. ⟨hal-02123778⟩
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  • Tourin Bzeih, Kena Zhang, Ali Khalaf, Ali Hachem, Mouad Alami, et al.. One-Pot Reaction between N -Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles. Journal of Organic Chemistry, 2019, 84 (1), pp.228-238. ⟨10.1021/acs.joc.8b02623⟩. ⟨hal-02414153⟩
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  • Ilhem Khelifi, Guangkuan Zhao, Nour-Eddine Ghermani, Olivier Provot, Mouad Alami. Unexpected Oxidative Ring Opening of Electron-Rich 3-Aminobenzofurans into α-Ketoimines Derivatives. Journal of Organic Chemistry, 2019, 84 (4), pp.1725-1733. ⟨10.1021/acs.joc.8b01685⟩. ⟨hal-02394232⟩
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  • Guangkuan Zhao, Christelle Roudaut, Vincent Gandon, Mouad Alami, Olivier Provot. Synthesis of 2-Substituted Indoles through Cyclization and Demethylation of 2-Alkynyldimethylanilines by Ethanol. Green Chemistry, 2019, 21 (15), pp.4204-4210. ⟨10.1039/c9gc01880h⟩. ⟨hal-03349087v2⟩
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  • Mouad Alami, Abdallah Hamze, Olivier Provot. Hydrostannation of Alkynes. ACS Catalysis, 2019, 9 (4), pp.3437-3466. ⟨10.1021/acscatal.9b00482⟩. ⟨hal-02394188⟩
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  • Ilhem Khelifi, Timothée Naret, Abdallah Hamze, Jérôme Bignon, Hélène Lévaique, et al.. N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents. European Journal of Medicinal Chemistry, 2019, 168, pp.176-188. ⟨10.1016/j.ejmech.2019.02.038⟩. ⟨hal-02394208⟩
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  • Nada Ibrahim, Mouad Alami, Samir Messaoudi. Recent Advances in Transition-Metal-Catalyzed Functionalization of 1-Thiosugars. Asian Journal of Organic Chemistry, 2018, 7 (10), pp.2026-2038. ⟨10.1002/ajoc.201800449⟩. ⟨hal-02414169⟩
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  • Félix Sauvage, Elias Fattal, Walhan Al-Shaer, Stéphanie Denis, Emilie Brotin, et al.. Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice. Cancer Letters, 2018, 432, pp.103-111. ⟨10.1016/j.canlet.2018.06.001⟩. ⟨inserm-02096216⟩
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  • Nicolas Probst, Gwendal Grelier, Slimane Dahaoui, Mouad Alami, Vincent Gandon, et al.. Palladium(II)-Catalyzed Diastereoselective 2,3-Trans C(sp 3 )–H Arylation of Glycosides. ACS Catalysis, 2018, 8 (9), pp.7781-7786. ⟨10.1021/acscatal.8b01617⟩. ⟨hal-01999466⟩
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  • Diana Lamaa, Hsin-Ping Lin, Lena Zig, Cyril Bauvais, Guillaume Bollot, et al.. Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso -Combretastatin A-4. Journal of Medicinal Chemistry, 2018, 61 (15), pp.6574-6591. ⟨10.1021/acs.jmedchem.8b00050⟩. ⟨hal-02309817⟩
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  • Sara Benmahdjoub, Nada Ibrahim, Belkacem Benmerad, Mouad Alami, Samir Messaoudi. One-Pot Assembly of Unsymmetrical Biaryl Thioglycosides through Chemoselective Palladium-Catalyzed Three-Component Tandem Reaction. Organic Letters, 2018, 20 (13), pp.4067-4071. ⟨10.1021/acs.orglett.8b01624⟩. ⟨hal-02414163⟩
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  • Florian Malard, Nadine Assrir, Mouad Alami, Samir Messaoudi, Ewen Lescop, et al.. Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation. Journal of Molecular Biology, 2018, 430 (11), pp.1621-1639. ⟨10.1016/j.jmb.2018.04.024⟩. ⟨hal-02114798⟩
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  • K. Harsha Vardhan Reddy, Expédite Yen-Pon, Sylvia Cohen-Kaminsky, Samir Messaoudi, Mouad Alami. Convergent Strategy to Dizocilpine MK-801 and Derivatives. Journal of Organic Chemistry, 2018, 83 (7), pp.4264-4269. ⟨10.1021/acs.joc.8b00305⟩. ⟨hal-02411576⟩
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  • Wafa Redjdal, Nada Ibrahim, Belkacem Benmerad, Mouad Alami, Samir Messaoudi. Convergent Synthesis of N,S-bis Glycosylquinolin-2-ones via a Pd-G3-XantPhos Precatalyst Catalysis. Molecules, 2018, 23 (3), pp.519. ⟨10.3390/molecules23030519⟩. ⟨hal-02414141⟩
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  • Guangkuan Zhao, Jérôme Bignon, Hélène Lévaique, Joëlle Dubois, Mouad Alami, et al.. One-Pot Synthesis of 2-Styrylindoles from Ortho -Substituted Chloroenynes. Journal of Organic Chemistry, 2018, 83 (24), pp.15323-15332. ⟨10.1021/acs.joc.8b02563⟩. ⟨hal-02394175⟩
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  • Guangkuan Zhao, Ling-Zhi Yuan, Mouad Alami, Olivier Provot. Chlorotrimethylsilane and Sodium Iodide: A Remarkable Metal-Free Association for the Desulfurization of Benzylic Dithioketals under Mild Conditions. Advanced Synthesis and Catalysis, 2018, 360 (13), pp.2522-2536. ⟨10.1002/adsc.201800437⟩. ⟨hal-02394255⟩
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  • Nicolas Probst, Rémy Lartia, Océane Théry, Mouad Alami, Eric Defrancq, et al.. Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation. Chemistry - A European Journal, 2018, 24 (8), pp.1795-1800. ⟨10.1002/chem.201705371⟩. ⟨hal-01846958⟩
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  • David Montoir, Mehdi Amora, Zine El Abidine Aabasa, Thimmalapura Marulappa Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-Mediated conjugation. Chemical Science, 2018, 9 (46), pp.8753-8759. ⟨10.1039/C8SC02370K⟩. ⟨hal-02622102⟩
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  • Tourin Bzeih, Diana Lamaa, Gilles Frison, Ali Hachem, Nada Jaber, et al.. Csp2–Csp2 and Csp2–N Bond Formation in a One-Pot Reaction between N-Tosylhydrazones and Bromonitrobenzenes: An Unexpected Cyclization to Substituted Indole Derivatives. Organic Letters, 2017, 19 (24), pp.6700 - 6703. ⟨10.1021/acs.orglett.7b03422⟩. ⟨hal-01673626⟩
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  • Thi Thanh Huyen Luong, Sabrina Touchet, Mouad Alami, Samir Messaoudi. Selective Palladium-Catalyzed Domino Heck/Buchwald-Hartwig Arylations of N -Glycosylcinnamamides: An Efficient Route to 4-Aryl- N -glycosylquinolin-2-ones. Advanced Synthesis and Catalysis, 2017, 359 (8), pp.1320-1330. ⟨10.1002/adsc.201601382⟩. ⟨hal-02031374⟩
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  • Ling-Zhi Yuan, Guangkuan Zhao, Abdallah Hamze, Mouad Alami, Olivier Provot. Chlorotrimethylsilane and Sodium Iodide: A Useful Combination for the Regioselective Deoxygenation of Arylalkyl-α-Diketones. Advanced Synthesis and Catalysis, 2017, 359 (15), pp.2682-2691. ⟨10.1002/adsc.201700276⟩. ⟨hal-02394293⟩
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  • Guangkuan Zhao, Ling-Zhi Yuan, Mouad Alami, Olivier Provot. Desulfurization of Thioketals into Methylene and Methyl Derivatives: Nickel or not Nickel?. ChemistrySelect, 2017, 2 (33), pp.10951-10959. ⟨10.1002/slct.201702370⟩. ⟨hal-02394278⟩
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  • Ling-Zhi Yuan, Abdallah Hamze, Mouad Alami, Olivier Provot. Synthesis of Substituted Benzils from Diarylalkyne Oxidation. Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (03), pp.504-525. ⟨10.1055/s-0036-1588608⟩. ⟨hal-02394330⟩
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  • Ilhem Khelifi, Timothée Naret, Dolor Renko, Abdallah Hamze, Guillaume Bernadat, et al.. Design, synthesis and anticancer properties of Iso CombretaQuinolines as potent tubulin assembly inhibitors. European Journal of Medicinal Chemistry, 2017, 127, pp.1025-1034. ⟨10.1016/j.ejmech.2016.11.012⟩. ⟨hal-02394312⟩
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  • Guangkuan Zhao, Mouad Alami, Olivier Provot. Synthesis and Functionalization of 3-Bromo-2-(2- chlorovinyl)benzothiophenes as Molecular Tools. RSC Advances, 2017, 73, ⟨10.1039/C7RA07340B⟩. ⟨hal-02910292⟩
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  • Guangkuan Zhao, Mouad Alami, Olivier Provot. Synthesis and functionalization of 3-bromo-2-(2-chlorovinyl)benzothiophenes as molecular tools. RSC Advances, 2017, 7 (73), pp.46007-46013. ⟨10.1039/c7ra07340b⟩. ⟨hal-02394339⟩
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  • Riyadh Ahmed Atto Al-Shuaeeb, Sergii Kolodych, Oleksandr Koniev, Sébastien Delacroix, Stéphane Erb, et al.. Palladium‐Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine‐Containing Molecules at Room Temperature. Chemistry - A European Journal, 2016, 22 (32), pp.11365-11370. ⟨10.1002/chem.201602277⟩. ⟨hal-04848149⟩
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  • Thi Thanh Huyen Luong, Jean-Daniel Brion, Ewen Lescop, Mouad Alami, Samir Messaoudi. Intramolecular Pd-Catalyzed Arylation of 1-Amidosugars: A New Route to N -Glycosyl Quinolin-2-ones. Organic Letters, 2016, 18 (9), pp.2126-2129. ⟨10.1021/acs.orglett.6b00752⟩. ⟨hal-02118684⟩
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  • Ling-Zhi Yuan, Dolor Renko, Ilhem Khelifi, Olivier Provot, Jean-Daniel Brion, et al.. Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide. Organic Letters, 2016, 18 (13), pp.3238-3241. ⟨10.1021/acs.orglett.6b01491⟩. ⟨hal-02394360⟩
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  • Guangkuan Zhao, Ling-Zhi Yuan, Mylène Roudier, Jean-François Peyrat, Abdallah Hamze, et al.. A Convenient Metal-Free Synthesis of (E)-3-Styrylisocoumarins through Annulation of (E)-1,4-Diarylenynes. Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (19), pp.3382-3392. ⟨10.1055/s-0035-1562501⟩. ⟨hal-02394350⟩
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  • Thi Thanh Huyen Luong, Etienne Brachet, Jean-Daniel Brion, Samir Messaoudi, Mouâd Alami. Palladium-Catalyzed Coupling of N -Amino­azoles with 3-Halo-Substituted ­Quinolin-2(1 H )-ones, Coumarins, Quin­oxalin-2(1 H )-ones, and Chromenes. European Journal of Organic Chemistry, 2015, 2015 (8), pp.1771-1780. ⟨10.1002/ejoc.201403501⟩. ⟨hal-03073839⟩
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  • Dolor Renko, Olivier Provot, Evelia Rasolofonjatovo, Jérôme Bignon, Jordi Rodrigo, et al.. Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.. European Journal of Medicinal Chemistry, 2015, 90, pp.834-844. ⟨hal-01121125⟩
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  • Mohamed Ali Soussi, Olivier Provot, Guillaume Bernadat, Jérôme Bignon, Déborah Desravines, et al.. IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity. ChemMedChem, 2015, 10 (8), pp.1392-1402. ⟨10.1002/cmdc.201500069⟩. ⟨hal-02394367⟩
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  • Bret Tréguier, Marie Lawson, Guillaume Bernadat, Jérôme Bignon, Joëlle Dubois, et al.. Synthesis of a 3-(α-styryl)benzo[b]-thiophene library via bromocyclization of alkynes and palladium-catalyzed to sylhydrazones cross-couplings: evaluation as antitubulin agents.. ACS Combinatorial Science, 2014, 16 (12), pp.702-710. ⟨hal-01110635⟩
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  • Maxime Roche, Jérôme Bignon, Jean-Daniel Brion, Abdallah Hamze, Mouad Alami. Tandem One-Pot Palladium-Catalyzed Coupling of Hydrazones, Haloindoles, and Amines: Synthesis of Amino-N-vinylindoles and Their Effect on Human Colon Carcinoma Cells.. Journal of Organic Chemistry, 2014, 79 (16), pp.7583-92. ⟨10.1021/jo501315q⟩. ⟨hal-01065681⟩
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  • Mohamed Ali Soussi, Olivier Provot, Guillaume Bernadat, Jérôme Bignon, Joanna Wdzieczak-Bakala, et al.. Discovery of azaisoerianin derivatives as potential antitumors agents. European Journal of Medicinal Chemistry, 2014, 78, pp.178-189. ⟨10.1016/j.ejmech.2014.03.032⟩. ⟨hal-02394376⟩
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  • Jessy Aziz, Gilles Frison, Montserrat Gomez, Jean-Daniel Brion, Abdallah Hamze, et al.. Copper-Catalyzed Coupling of N-Tosylhydrazones with Amines: Synthesis of Fluorene Derivatives. ACS Catalysis, 2014, 4, pp.4498-4503. ⟨10.1021/cs5014877⟩. ⟨hal-01080685⟩
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  • Etienne Brachet, Jean-Daniel Brion, Mouad Alami, Samir Messaoudi. Nickel-Catalyzed Arylation, Alkenylation, and Alkynylation of Unprotected Thioglycosides at Room Temperature. Chemistry - A European Journal, 2013, 19 (45), pp.15276-15280. ⟨10.1002/chem.201302999⟩. ⟨hal-03073844⟩
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  • Etienne Brachet, Jean-Daniel Brion, Mouad Alami, Samir Messaoudi. Stereoselective Palladium-Catalyzed Alkenylation and Alkynylation of Thioglycosides. Advanced Synthesis and Catalysis, 2013, 355 (13), pp.2627-2636. ⟨10.1002/adsc.201300419⟩. ⟨hal-03073842⟩
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  • Marie Lawson, Abdallah Hamze, Jean-François Peyrat, Jérôme Bignon, Joelle Dubois, et al.. An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.. Organic & Biomolecular Chemistry, 2013, 11 (22), pp.3664-73. ⟨10.1039/c3ob40263k⟩. ⟨hal-00853049⟩
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  • Etienne Brachet, Jean-Daniel Brion, Samir Messaoudi, Mouad Alami. Palladium-Catalyzed Cross-Coupling Reaction of Thioglycosides with (Hetero)aryl Halides. Advanced Synthesis and Catalysis, 2013, pp.n/a-n/a. ⟨10.1002/adsc.201200695⟩. ⟨hal-03073850⟩
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  • Jessy Aziz, Etienne Brachet, Abdallah Hamze, Jean-François Peyrat, Guillaume Bernadat, et al.. Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.. Organic & Biomolecular Chemistry, 2013, 11 (3), pp.430-42. ⟨10.1039/c2ob26253c⟩. ⟨hal-00798259⟩
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  • Maxime Roche, Gilles Frison, Jean-Daniel Brion, Olivier Provot, Abdallah Hamze, et al.. Csp2-N Bond Formation via Ligand-Free Pd-Catalyzed Oxidative Coupling Reaction of N-Tosylhydrazones and Indole Derivatives. Journal of Organic Chemistry, 2013, 78, pp.8485-8495. ⟨10.1021/jo401217x⟩. ⟨hal-00849710⟩
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  • Evelia Rasolofonjatovo, Jérome Bignon, Olivier Provot, Abdallah Hamze, Jordi Rodrigo, et al.. Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted iso combretastatin A-4 analogs. European Journal of Medicinal Chemistry, 2013, 62, pp.28-39. ⟨10.1016/j.ejmech.2012.12.042⟩. ⟨hal-02394390⟩
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  • Jessy Aziz, Etienne Brachet, Abdallah Hamze, Jean-François Peyrat, Guillaume Bernadat, et al.. Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors. Organic & Biomolecular Chemistry, 2013, 11 (3), pp.430-442. ⟨10.1039/c2ob26253c⟩. ⟨hal-03073854⟩
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  • Etienne Brachet, Jean-François Peyrat, Jean-Daniel Brion, Samir Messaoudi, Mouâd Alami. A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles. Organic & Biomolecular Chemistry, 2013, 11 (23), pp.3808. ⟨10.1039/c3ob40338f⟩. ⟨hal-03073852⟩
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  • Jessy Aziz, Gilles Frison, Patrick Le Menez, Jean-Daniel Brion, Abdallah Hamze, et al.. Gold versus Palladium: A Regioselective Cycloisomerization of Aromatic Enynes. Advanced Synthesis and Catalysis, 2013, 355, pp.3425-3436. ⟨10.1002/adsc.201300746⟩. ⟨hal-00872551⟩
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  • Olivier Provot, Abdallah Hamze, Jean-François Peyrat, Jean-Daniel Brion, Mouad Alami. Discovery and Hit to Lead Optimization of Novel Combretastatin A-4 Analogues: Dependence of C-Linker Length and Hybridization. Anti-Cancer Agents in Medicinal Chemistry, 2013, 13 (10), pp.1614-1635. ⟨10.2174/187152061310131206162302⟩. ⟨hal-02394384⟩
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  • Etienne Brachet, Samir Messaoudi, Jean-François Peyrat, Jean-Daniel Brion, Mouad Alami. Palladium-Catalyzed Cross-Coupling of 1-Aminoazoles with Aryl Chlorides: Application to the Synthesis of Unsymmetrical N,N′ -Diaryl-1-aminoindoles. Advanced Synthesis and Catalysis, 2012, 354 (14-15), pp.2829-2839. ⟨10.1002/adsc.201200440⟩. ⟨hal-03073855⟩
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  • Evelia Rasolofonjatovo, Bret Tréguier, Olivier Provot, Abdallah Hamze, Jean-Daniel Brion, et al.. A One-Pot Three-Step Synthesis of Z-Trisubstituted Olefins from Arylalkynes and Their Cyclization into 4-Aryl-2H-chromenes. European Journal of Organic Chemistry, 2012, 2012 (8), pp.1603-1615. ⟨10.1002/ejoc.201101735⟩. ⟨hal-02394410⟩
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  • Evelia Rasolofonjatovo, Olivier Provot, Abdallah Hamze, Jordi Rodrigo, Jérôme Bignon, et al.. Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity. European Journal of Medicinal Chemistry, 2012, 52, pp.22-32. ⟨10.1016/j.ejmech.2012.03.001⟩. ⟨hal-02394400⟩
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  • Mohamed Ali Soussi, Silvio Aprile, Samir Messaoudi, Olivier Provot, Erika del Grosso, et al.. The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.. ChemMedChem, 2011, 6 (10), pp.1781-1788. ⟨10.1002/cmdc.201100193⟩. ⟨hal-00649286⟩
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  • Samir Messaoudi, Abdallah Hamze, Olivier Provot, Bret Tréguier, Jordi Rodrigo de losada, et al.. Discovery of Isoerianin Analogues as Promising Anticancer Agents. ChemMedChem, 2011, 6 (3), pp.488-497. ⟨10.1002/cmdc.201000456⟩. ⟨hal-02394454⟩
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  • Evelia Rasolofonjatovo, Bret Tréguier, Olivier Provot, Abdallah Hamze, Estelle Morvan, et al.. Palladium-catalyzed coupling of N-tosylhydrazones with ortho substituted aryl halides: synthesis of 4-arylchromenes and related heterocycles. Tetrahedron Letters, 2011, 52 (9), pp.1036-1040. ⟨10.1016/j.tetlet.2010.12.093⟩. ⟨hal-02394469⟩
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  • Mohamed Ali Soussi, Davide Audisio, Samir Messaoudi, Olivier Provot, Jean-Daniel Brion, et al.. Palladium-Catalyzed Coupling of 3-Halo-Substituted Coumarins, Chromenes, and Quinolones with Various Nitrogen-Containing Nucleophiles. European Journal of Organic Chemistry, 2011, 2011 (26), pp.5077-5088. ⟨10.1002/ejoc.201100480⟩. ⟨hal-02394445⟩
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  • Abdallah Hamze, Evelia Rasolofonjatovo, Olivier Provot, Céline Mousset, Damien Veau, et al.. B-Ring-Modified isoCombretastatin A-4 Analogues Endowed with Interesting Anticancer Activities. ChemMedChem, 2011, 6 (12), pp.2179-2191. ⟨10.1002/cmdc.201100325⟩. ⟨hal-02394426⟩
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  • Bret Tréguier B., Evelia Rasolofonjatovo, Abdallah Hamze, Olivier Provot, Joanna Wdzieczak-Bakala, et al.. Synthesis of 2-(1-phenylvinyl)benzofurans and 2-(1-phenylvinyl)indoles as antimitotic agents by a tandem palladium-assisted coupling-cyclization reaction between 1-phenylvinyl iodides and ortho-substituted arylalkynes. European Journal of Organic Chemistry, 2011, 25, pp.4868-4876. ⟨hal-00647619⟩
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  • Etienne Brachet, Abdallah Hamze, Jean-François Peyrat, Jean-Daniel Brion, Mouad Alami. Pd-Catalyzed Reaction of Sterically Hindered Hydrazones with Aryl Halides: Synthesis of Tetra-Substituted Olefins Related to iso -Combretastatin A4. Organic Letters, 2010, 12 (18), pp.4042-4045. ⟨10.1021/ol101639g⟩. ⟨hal-03073857⟩
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  • Maud Jacubert, Olivier Provot, Jean-François Peyrat, Abdallah Hamze, Jean-Daniel Brion, et al.. p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles. Tetrahedron, 2010, 66 (21), pp.3775-3787. ⟨10.1016/j.tet.2010.03.055⟩. ⟨hal-02394573⟩
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  • Abdellatif Tikad, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Mouad Alami. Suzuki Coupling Reactions of ( E )- and ( Z )-Chloroenynes with Boronic Acids: Versatile Access to Functionalized 1,3-Enynes. European Journal of Organic Chemistry, 2010, 2010 (4), pp.725-731. ⟨10.1002/ejoc.200901137⟩. ⟨hal-02394582⟩
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  • Maud Jacubert, Abdellatif Tikad, Olivier Provot, Abdallah Hamze, Jean-Daniel Brion, et al.. MPHT-Promoted Bromocyclization of ortho-Substituted Arylalkynes: Application to the Synthesis of 2-Substituted 3-Bromobenzofurans and -Benzo[b]thiophenes. European Journal of Organic Chemistry, 2010, 2010 (23), pp.4492-4500. ⟨10.1002/ejoc.201000529⟩. ⟨hal-02394491⟩
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  • Patrick Le Menez, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Mouad Alami. Tributyltin Hydride in NMP-Promoted Reduction of Acid Chlorides to Aldehydes under Transition-Metal-Free Conditions. SYNLETT, 2010, 2010 (07), pp.1101-1103. ⟨10.1055/s-0029-1219796⟩. ⟨hal-02394579⟩
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  • Abdallah Hamze, Patrick Le Menez, Olivier Provot, Estelle Morvan, Jean-Daniel Brion, et al.. Regioselective Hydrostannation of Highly Hindered Arylalkynes under Ortho Directing Effects. Tetrahedron, 2010, 66 (45), pp.8698-8706. ⟨10.1016/j.tet.2010.09.010⟩. ⟨hal-02394476⟩
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  • Evelia Rasolofonjatovo, Olivier Provot, Abdallah Hamze, Jérôme Bignon, Sylviane Thoret, et al.. Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4. European Journal of Medicinal Chemistry, 2010, 45 (9), pp.3617-3626. ⟨10.1016/j.ejmech.2010.05.007⟩. ⟨hal-02394481⟩
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  • Samir Messaoudi, Bret Tréguier, Abdallah Hamze, Olivier Provot, Jean-François Peyrat, et al.. Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.. Journal of Medicinal Chemistry, 2009, 52 (14), pp.4538-42. ⟨10.1021/jm900321u⟩. ⟨hal-00421101⟩
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  • Jean-Daniel Brion, Mouad Alami, Bret Tréguier, Abdallah Hamze, Olivier Provot. Expeditious synthesis of 1,1-diarylethylenes related to isocombretastatin A-4 (isoCA-4) via palladium-catalyzed arylation of N-tosylhydrazones with aryl triflates. Tetrahedron Letters, 2009, 50 (47), pp.6549-6552. ⟨10.1016/j.tetlet.2009.09.046⟩. ⟨hal-02394584⟩
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  • Abdallah Hamze, Anne Giraud, Samir Messaoudi, Olivier Provot, Jean-François Peyrat, et al.. Synthesis, Biological Evaluation of 1,1-Diarylethylenes as a Novel Class of Antimitotic Agents. ChemMedChem, 2009, 4 (11), pp.1912-1924. ⟨10.1002/cmdc.200900290⟩. ⟨hal-02394586⟩
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  • Céline Mousset, Olivier Provot, Abdallah Hamze, Jérôme Bignon, Jean-Daniel Brion, et al.. DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles. Tetrahedron, 2008, 64 (19), pp.4287-4294. ⟨10.1016/j.tet.2008.02.081⟩. ⟨hal-02394600⟩
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  • Anne Giraud, Olivier Provot, Abdallah Hamze, Jean-Daniel Brion, Mouad Alami. One-pot hydrosilylation–protodesilylation of functionalized diarylalkynes: a highly selective access to Z-stilbenes. Application to the synthesis of combretastatin A-4. Tetrahedron Letters, 2008, 49 (7), pp.1107-1110. ⟨10.1016/j.tetlet.2007.12.057⟩. ⟨hal-02394604⟩
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  • Céline Mousset, Anne Giraud, Olivier Provot, Abdallah Hamze, Jérôme Bignon, et al.. Synthesis and antitumor activity of benzils related to combretastatin A-4. Bioorganic and Medicinal Chemistry Letters, 2008, 18 (11), pp.3266-3271. ⟨10.1016/j.bmcl.2008.04.053⟩. ⟨hal-02394592⟩
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  • Gaëlle Le Bras, Abdallah Hamze, Samir Messaoudi, Olivier Provot, Pierre-Benoît Le Calvez, et al.. Synthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes. Synthesis: Journal of Synthetic Organic Chemistry, 2008, 2008 (10), pp.1607-1611. ⟨10.1055/s-2008-1072575⟩. ⟨hal-02394596⟩
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  • Delphine Girard, Sylvie Broussous, Olivier Provot, Jean-Daniel Brion, Mouad Alami. Palladium mediated direct coupling of silylated arylalkynes with propargylic chlorides: an efficient access to functionalized conjugated allenynes. Tetrahedron Letters, 2007, 48 (34), pp.6022-6026. ⟨10.1016/j.tetlet.2007.06.079⟩. ⟨hal-02394606⟩
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  • Gaëlle Le Bras, Olivier Provot, Jean-François Peyrat, Mouad Alami, Jean-Daniel Brion. Rapid microwave assisted hydration of internal arylalkynes in the presence of PTSA: an efficient regioselective access to carbonyl compounds. Tetrahedron Letters, 2006, 47 (31), pp.5497-5501. ⟨10.1016/j.tetlet.2006.05.155⟩. ⟨hal-02394618⟩
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  • Anne Giraud, Olivier Provot, Jean-François Peyrat, Mouad Alami, Jean-Daniel Brion. Microwave-assisted efficient synthesis of 1,2-diaryldiketones: a novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3. Tetrahedron, 2006, 62 (33), pp.7667-7673. ⟨10.1016/j.tet.2006.05.072⟩. ⟨hal-02394615⟩
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  • Nathalie L'Hermite, Anne Giraud, Olivier Provot, Jean-François Peyrat, Mouad Alami, et al.. Disproportionation reaction of diarylcarbinols: a versatile access to diarylmethanes speeded up using microwave irradiation. Tetrahedron, 2006, 62 (51), pp.11994-12002. ⟨10.1016/j.tet.2006.09.083⟩. ⟨hal-02394612⟩
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  • Gaëlle Le Bras, Olivier Provot, Alain Bekaert, Jean-François Peyrat, Mouad Alami, et al.. α-Iodination of Ketones with MnO 2 /I 2 Reagent Combination: A New Environmentally Friendly Procedure. Synthesis: Journal of Synthetic Organic Chemistry, 2006, 2006 (9), pp.1537-1541. ⟨10.1055/s-2006-926435⟩. ⟨hal-02394625⟩
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  • Olivier Provot, Anne Giraud, Jean-François Peyrat, Mouad Alami, Jean-Daniel Brion. Synthetic approach to enyne and enediyne analogues of anticancer agents. Tetrahedron Letters, 2005, 46 (49), pp.8547-8550. ⟨10.1016/j.tetlet.2005.10.001⟩. ⟨hal-02394628⟩
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  • Alain Bekaert, Olivier Provot, Olimihamina Rasolojaona, Mouad Alami, Jean-Daniel Brion. N-Methylpyrrolidin-2-one hydrotribromide (MPHT) a mild reagent for selective bromination of carbonyl compounds: synthesis of substituted 2-bromo-1-naphtols. Tetrahedron Letters, 2005, 46 (24), pp.4187-4191. ⟨10.1016/j.tetlet.2005.04.049⟩. ⟨hal-02394630⟩
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Communications dans un congrès2 document




    

  • Ross Ballantine, Ameni Hadj Mohamed, Mingxiang Zhu, Aromal Asokan, Linhua Shen, et al.. Palladium-mediated S-arylation and S-allylation for late-stage peptide functionalisation and protein conjugation. 37. European Peptide Symposium. 14. International Peptide Symposium, Aug 2024, Florence, Italy. pp.692-P2.010. ⟨hal-05075799⟩
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  • David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, T.M. Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation. 4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France. ⟨hal-02892772⟩
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Poster de conférence1 document




    

  • David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, Thimmalapura Marulappa Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-Thioglycopeptides through chemoselective Pd-catalyzed conjugation. 35 th European Peptide Symposium, Aug 2018, Dublin, Ireland. 2018. ⟨hal-02734043⟩
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Chapitres d'ouvrage1 document














Brevets2 document




    

  • Mouad Alami, Jean-Daniel Brion, Samir Messaoudi, Sabrina Touchet, Gilles Galvani, et al.. Modulateurs de récepteurs NMDA, compositions les comprenant et utilisation de ces composés dans le traitement de maladies impliquant le système nerveux central. France, N° de brevet: FR 3067028 A1. 2018. ⟨hal-02543271⟩
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  • Sabrina Touchet, Mouad Alami, Jean-Daniel Brion, Olivier Dulac, Svetlana Gataullina, et al.. Modulateurs de récepteurs NMDA, compositions les comprenant et utilisation de ces composés dans le traitement de maladies impliquant le système nerveux central.. France, N° de brevet: FR 3055331 A1. 2018. ⟨hal-02543339⟩
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Mouâd ALAMI was born in 1959 in Fez (Morocco). He did his undergraduate studies at the University Pierre and Marie Curie in Paris and his PhD in 1987 at the same university with Pr. J.-F. Normant and G. Cahiez.


After a two years (1987-89) post-doctoral position in collaboration with the Elf- Atochem company he joined on 1989 the CNRS (National Center for Scientific Research) at the Ecole Normale Superieure, ENS-Paris (Dr. G. Linstrumelle).


In 1993, he spent one year of postdoctoral studies at the University of Santa-Barbara in the laboratory of Prof. B. H. Lipshutz and in 1997, he moved as an independent researcher at the CNRS to Cergy-Pontoise University.


In 1999, he accepted a position at the, Faculty of Pharmacy (University Paris-Sud) where he became Director of research at the CNRS. He published more than 160 papers, 5 international patents and 10 book chapters. Dr. ALAMI, team leader within the UMR BioCIS, was a member of the Scientific Council of the Department of Chemistry and the National Committee of CNRS – Section 12 (2004-08) and in 2012 was appointed to the National Council of universities (CNU Section-32).


Since 2008 he is a deputy director of the UMR 8076 – BioCIS