Nadège LUBIN-GERMAIN 

Professor

“Biological Chemistry” team leader

Deputy Director of Research at the Graduate School CY Tech



Biological Chemistry, Permanent


bureau
nadege.lubin-germain@cyu.fr




site de Cergy


ORCID
https://orcid.org/0000-0003-0713-9286


    

  • Glycochemistry : development of methodologies applied to the synthesis of C-glycosides
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  • medicinal chemistry:

      

    • synthesis of C-nucleosides for antiviral and antitumor activities
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    • vectorization: development of C-glycosidic structures as ligands of lectins, vectorization to hepatocytes
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  • peptide chemistry: synthesis and study of the membranotropic/fusogenic properties of fusion peptides of the hepatitis C virus
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  • Cultural heritage sciences : copper pigment stability, Blanching of paint and varnish layers
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31 documents







Journal articles25 document




    

  • Quentin Joachim, Delphine Carry, Mattéo Di Pasquale, Jérôme Marrot, Suzuka Yamamoto, et al.. Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium‐Catalyzed Cross‐Coupling Reactions. European Journal of Organic Chemistry, 2025, 28 (32), ⟨10.1002/ejoc.202500502⟩. ⟨hal-05326462⟩
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  • Yuqing Zhang, Myriam Eveno, Nadège Lubin-Germain, Agnès Lattuati-Derieux, Nadège Lubin-Germain, et al.. Partially fluorinated derivatives as a powerful tool for the restoration of blanched easel paintings. Progress in Organic Coatings, 2025, 207, pp.109375. ⟨10.1016/j.porgcoat.2025.109375⟩. ⟨hal-05104320⟩
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  • Bartosz Godlewski, Nina Bozinovic, Quentin Joachim, Olivier Monasson, Nadège Lubin-Germain, et al.. Direct palladium-catalyzed C–H arylation of bioactive triazolyl- C -nucleosides on a key position of the heterocyclic base. Chemical Communications, 2025, 61 (85), pp.16584-16587. ⟨10.1039/D5CC04215A⟩. ⟨hal-05349690⟩
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  • Leandro Soter de Mariz E Miranda, Raoni Schroeder Borges Gonçalves, Nadège Lubin-Germain, Satoshi Obika. Editorial: Nucleosides, nucleotides and nucleic acids: chemistry and biology. Frontiers in Chemistry, 2024, 12, ⟨10.3389/fchem.2024.1401510⟩. ⟨hal-05325392⟩
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  • Sarah Moreira Rodrigues Do Nascimento, Angélique Ferry, Florian Gallier, Nadège Lubin-Germain, Jacques Uziel, et al.. Developments in the chemistry and biology of 1,2,3‐triazolyl‐C‐nucleosides. Archiv der Pharmazie / Chemistry in Life Sciences, 2023, 357 (3), ⟨10.1002/ardp.202300580⟩. ⟨hal-05352938⟩
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  • Camille Lozada, Simon Gonzalez, Rémy Agniel, Mathilde Hindie, Luca Manciocchi, et al.. Introduction of constrained Trp analogs in RW9 modulates structure and partition in membrane models. Bioorganic Chemistry, 2023, 139, pp.106731. ⟨10.1016/j.bioorg.2023.106731⟩. ⟨hal-04272386⟩
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  • Yuqing Zhang, Myriam Eveno, Florian Gallier, Mara Camaiti, Agnès Lattuati-Derieux, et al.. Synthesis of novel partially perfluorinated C-glycosides and their application in blanching easel painting restoration. Journal of Cultural Heritage, 2023, 62, pp.493-500. ⟨10.1016/j.culher.2023.06.019⟩. ⟨hal-04172828⟩
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  • Nazarii Sabat, Abdelhakim Ouarti, Evelyne Migianu-Griffoni, Marc Lecouvey, Olivier Ferraris, et al.. Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs. Bioorganic Chemistry, 2022, 122, pp.105723. ⟨10.1016/j.bioorg.2022.105723⟩. ⟨hal-03627511⟩
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  • Olivier Monasson, Maciej Malinowski, Nadège Lubin-Germain, Angélique Ferry. Hirao Cross-Coupling Reaction as an Efficient Tool to Build Non-natural C2-Phosphonylated Sugars. Synthesis: Journal of Synthetic Organic Chemistry, 2022, ⟨10.1055/a-1709-3305⟩. ⟨hal-03630601⟩
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  • Camille Lozada, Thomas M A Barlow, Simon Gonzalez, Nadège Lubin-Germain, Steven Ballet. Identification and Characteristics of Fusion Peptides Derived From Enveloped Viruses. Frontiers in Chemistry, 2022, 12, pp.689006. ⟨10.3389/fchem.2021.689006⟩. ⟨hal-03714204⟩
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  • Yuqing Zhang, Laura Vespignani, Maria Grazia Balzano, Leonardo Bellandi, Mara Camaiti, et al.. Low Fluorinated Oligoamides for Use as Wood Protective Coating. Coatings, 2022, 12 (7), pp.927. ⟨10.3390/coatings12070927⟩. ⟨hal-03714187⟩
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  • Oriana Osta, Marianne Bombled, David Partouche, Florian Gallier, Nadège Lubin-Germain, et al.. Direct Synthesis of Mesoporous Organosilica and Proof-of-Concept Applications in Lysozyme Adsorption and Supported Catalysis. ACS Omega, 2020, 5 (30), pp.18842-18848. ⟨10.1021/acsomega.0c01996⟩. ⟨hal-03036887⟩
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  • Oriana Osta, Marianne Bombled, David Partouche, Florian Gallier, Nadège Lubin-Germain, et al.. Direct Synthesis of Mesoporous Organosilica and Proof-of-Concept Applications in Lysozyme Adsorption and Supported Catalysis. ACS Omega, 2020, 5, pp.18842 - 18848. ⟨10.1021/acsomega.0c01996⟩. ⟨hal-03553249⟩
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  • Nazarii Sabat, Evelyne Migianu-Griffoni, Tiffany Tudela, Marc Lecouvey, Sabrina Kellouche, et al.. Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin. European Journal of Medicinal Chemistry, 2020, 188, pp.112009. ⟨10.1016/j.ejmech.2019.112009⟩. ⟨hal-03364298⟩
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  • Anaïs Wambecke, Carine Laurent-Issartel, Johanne Leroy-Dudal, Florence Giffard, Fanny Cosson, et al.. Evaluation of the potential of a new ribavirin analog impairing the dissemination of ovarian cancer cells. PLoS ONE, 2019, 14 (12), pp.e0225860. ⟨10.1371/journal.pone.0225860⟩. ⟨inserm-02429497⟩
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  • Marion Alter, Laurent Binet, Nadia Touati, Nadège Lubin-Germain, Anne-Solenn Le Hô, et al.. Photochemical Origin of the Darkening of Copper Acetate and Resinate Pigments in Historical Paintings. Inorganic Chemistry, 2019, 58 (19), pp.13115-13128. ⟨10.1021/acs.inorgchem.9b02007⟩. ⟨hal-03773633⟩
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  • Morgane de Robichon, Andrea Bordessa, Nadège Lubin-Germain, Angélique Ferry. “CO” as a Carbon Bridge to Build Complex C2-Branched Glycosides Using a Palladium-Catalyzed Carbonylative Suzuki–Miyaura Reaction from 2-Iodoglycals. Journal of Organic Chemistry, 2019, 84 (6), pp.3328-3339. ⟨10.1021/acs.joc.8b03248⟩. ⟨hal-03821214⟩
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  • Simon Gonzalez, Florian Gallier, Sabrina Kellouche, Franck Carreiras, Ettore Novellino, et al.. Studies of membranotropic and fusogenic activity of two putative HCV fusion peptides. Biochimica et Biophysica Acta:Biomembranes, 2019, 1861 (1), pp.50-61. ⟨10.1016/j.bbamem.2018.10.011⟩. ⟨hal-01920493⟩
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  • Grégory Legrave, Ramzi Ait Youcef, Damien Afonso, Angélique Ferry, Jacques Uziel, et al.. Synthesis of C -pyrimidyl nucleosides starting from alkynyl ribofuranosides. Carbohydrate Research, 2018, 462, pp.50-55. ⟨10.1016/j.carres.2018.04.005⟩. ⟨hal-05357575⟩
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  • Jacques Uziel, Fanny Cosson, Aline Faroux, Jean-Pierre Baltaze, Jonathan Farjon, et al.. Synthesis of ribavirin 2’-Me-C-nucleoside analogues. Beilstein Journal of Organic Chemistry, 2017, 13, pp.755 - 761. ⟨10.3762/bjoc.13.74⟩. ⟨hal-03553300⟩
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  • Nadege Lubin-Germain, Jacques Uziel, Patrick Wagner, Alexandra Basilio-Lopes, Martine Schmitt, et al.. Functionalization of 2H 1,2,3-Triazole C-Nucleoside Template via N2 Selective Arylation. Journal of Organic Chemistry, 2016, 11, pp.4540-4549. ⟨10.1021/acs.joc.6b00323⟩. ⟨hal-02980120⟩
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  • Nadege Lubin-Germain, Andrea Bordessa, Angélique Ferry. Access to complex C2-branched glycoconjugates via palladium-catalyzed aminocarbonylation reaction of 2-iodoglycals.. Journal of Organic Chemistry, 2016, 24, pp.12459-12465. ⟨10.1021/acs.joc.6b02278⟩. ⟨hal-02980121⟩
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  • Ibtissem Jlalia, Florian Gallier, Nancy Brodie-Linder, Jacques Uziel, Jacques Augé, et al.. Copper(II) SBA-15: A reusable catalyst for azide–alkyne cycloaddition. Journal of Molecular Catalysis A: Chemical, 2014, 393, pp.56-61. ⟨10.1016/j.molcata.2014.06.003⟩. ⟨hal-03553460⟩
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  • Chiara Testa, Mario Scrima, Manuela Grimaldi, Anna M D’ursi, Marvin L Dirain, et al.. 1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: Design, Synthesis, Conformational Analysis, and Biological Activity. Journal of Medicinal Chemistry, 2014, 57, pp.9424 - 9434. ⟨10.1021/jm501027w⟩. ⟨hal-05104322⟩
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  • Dancho Lyubenov Danalev, Nadege Lubin-Germain, Stephane Serfaty, Jean-Yves Le Huerou, Jacques Augé, et al.. Titan Based Hybrid Organic-Inorganic Gels Comprising Carbohydrate Moiety. Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (11), pp.2216-2225. ⟨10.1080/10426507.2011.586384⟩. ⟨hal-00750858⟩
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Conference papers1 document




    

  • Virginie Doceul, Vincent Mallet, Nadege Lubin-Germain, Benjamin Onfroy, Jacques Uziel, et al.. Effect of a ribavirin analogue on the replication of hepatitis E virus in vitro. 17. Réunion du Réseau National Hépatites, Agence Nationale de la Recherche sur le SIDA et les hépatites (ANRS). FRA.; Université de Cergy Pontoise. FRA., Mar 2017, Paris, France. ⟨hal-02784814⟩
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Poster communications3 document




    

  • Nadège Lubin-Germain. Model-guided design of bactericidal agents from viral fusion peptides. ChemBioParis, Oct 2025, Paris, France. ⟨hal-05312268⟩
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  • Camille Dejoux, Manuela Pastoriza-Gallego, Nadège Lubin-Germain, Simon Gonzalez, Abdelghani Oukhaled. Cell penetrating peptides probed by nanopores. Biophysical Society annual symposium, Feb 2025, Los Angeles, United States. . ⟨hal-05312263⟩
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  • Virginie Doceul, Vincent Mallet, Nadege Lubin-Germain, Benjamin Onfroy, Jacques Uziel, et al.. Impact d’un analogue de la ribavirine sur la réplication du virus de l’hépatite E in vitro. 19. Journées Francophones de Virologie, Mar 2017, Paris, France. John Libbey Eurotext, Virologie, 21, pp.93-100, 2017, ⟨10.1684/vir.2017.0691⟩. ⟨hal-02733548⟩
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Book sections2 document




    

  • A Ferry, Florian Gallier, S Gonzalez, N Lubin-Germain, L Soter de Mariz E Miranda, et al.. Enabling technologies applied to glycosylation. Carbohydrate Chemistry: Chemical and Biological Approaches, 46, pp.44-72, 2024, 978-1-83767-217-2. ⟨10.1039/9781837672844-00044⟩. ⟨hal-05352935⟩
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  • Angélique Ferry, Florian Gallier, Simon Gonzalez, Nadège Lubin-Germain, Leandro Soter de Mariz E Miranda, et al.. Recent advances in the functionalization of unprotected carbohydrates. Amélia Pilar Rauter; Thisbe K Lindhorst; Yves Queneau. Carbohydrate Chemistry: Chemical and Biological Approaches, 45, Royal Society of Chemistry, pp.239-304, 2021, SPR - Carbohydrate Chemistry, 978-1-83916-390-6. ⟨10.1039/9781839164538-00239⟩. ⟨hal-03667486⟩
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Education


2004 Habilitation à Diriger des Recherches, University of Cergy-Pontoise


1993 PhD, University of Paris-Sud (Orsay)


1989 Master, University of Paris-Sud (Orsay)


Work Experience




2010 –  Professor , University of Cergy-Pontoise


2002-2003: Délégation CNRS


1994-2010 Maître de Conférences, University of Cergy-Pontoise


Laboratoire de synthèse organique sélective et de chimie Organique


1993-1994:Attachée Temporaire d’Enseignement et de Recherche, University of Cergy – Pontoise


1992-93 Postdoctoralposition, Institut für Biotechnologie 2, Forschungszentrum Jülich (Germany).


1989-92 PhD, University of Paris-Sud (Orsay)


Responsabilities




2020- Member of the Conseil d’Etablissement CY Cergy-Paris University


2014-15 Member of the scientific council UCP


2014- Coordination of 6 Cursus of Master in Ingeniery, Faculty of Sciences, UCP


2014-16 Head of the department of chemistry, UCP


2012-15 Member of the CNU, national council of the Universities, section 32


2011-14 Directrice adjointe du département de chimie


2008-10 Member of the scientific council UCP