publi-eq1

MS2DECIDE: Aggregating Multiannotated Tandem Mass Spectrometry Data with Decision Theory Enhances Natural Products Prioritization

2025-12-17T11:45:21+01:00publi-eq1|

Abstract Mass spectrometry-based natural products (NPs) targeted discovery often relies on a complicated decision-making process involving tedious comparison of [...]

C9-Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α-Synuclein Aggregation and Neuroinflammation in Parkinson’s Disease Degeneration

2026-01-06T16:22:26+01:00publi-eq1|

Abstract Doxycycline, a semi-synthetic tetracycline, is a widely used antibiotic for treating mild-to-moderate infections, including skin problems. However, its [...]

Mo-catalyzed cyclization of N-vinylindoles and skatoles : synthesis of dihydroindolo[1,2-c]-quinazolines and dihydroindolo[3,2-b]-indoles, and evaluation of their anticancer activities

2025-12-16T10:20:47+01:00publi-eq1|

A novel synthesis method using N-vinylazoles produces unexpected compounds DINQ (R= Me) and DINI (R= H). Mocatalyst is crucial [...]

Bioinspired Divergent Oxidative Cyclizations of Geissoschizine : Total Synthesis of (–)-17-nor-Excelsinidine, (+)-16-epi-Pleiocarpamine, (+)-16-Hydroxymethyl-pleiocarpamine and (+)-Taberdivarine H

2025-12-12T08:50:16+01:00publi-eq1|

Erwan Poupon, Laurent Evanno, Guillaume Vincent et al. En couverture de L’European Journal of Organic Chimistry (EurJOC) un travail collaboratif réalisé [...]

Access to Functionalized 3,5-Disubstituted 1,2-Dioxolanes under Mild Conditions through InCl3/TMSCl or Sc(OTf)3

2025-12-12T08:50:16+01:00publi-eq1|

Alexis Pinet, Bruno Figadère, Laurent Ferrié Nous rapportons ici une amélioration notable de la fonctionnalisation d’endoperoxydes, particulièrement des 1,2-dioxolanes. Les méthodologies [...]

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