Chiral fluorinated compounds

Stereoselective synthesis of fluorinated amino acids, amino alcohols, pseudoprolines, …

Fluorinated peptides and peptidomimetics

Development of coupling conditions for the incorporation of fluorinated aminoacids into peptide chains;
Design and synthesis of fluorinated peptides and peptidomimetics of biological interests (nociception, antimicrobial peptides, PPIase inhibition, …);
Design of fluorinated biomaterials and peptidomimrtics (collagen model peptides, foldamers, peptide hydrogels, …)

Physicochemical properties, conformational and structural analysis, biological activities

Evaluation of kinetic and thermodynamic parameters, hydrophobicity index measurement, measurement of the pKa values of the neighboring chemical functions, assignement of peptide amide bond geometry and ring pucker conformation, secondary structure elucidation, thermal stability of tertiary structure, protein-protein interactions, capacity to interact with membranes or to cross them, use of the fluorinated groups as 19F NMR probe, antimicrobial activity, inhibition of amyloid protein aggregation, analgesia, …

Education
DEUG Sciences de la Matières option « Physique-Chimie » (1997), University of Cergy-Pontoise
Licence de Chimie – B.Sc. (1998), University of Cergy-Pontoise
Maitrise de Chimie Organique (1999), University of Cergy-Pontoise
DEA de Chimie Organique – M.Sc. (2000),University of Cergy-Pontoise
Doctorat de Chimie Organique – PhD (2003), University of Cergy-Pontoise, direction : J. Ardisson & A. Pancrazi

Career
Post-doc (2003-2004) : Nottingham University, England (Prof G. Pattenden)
ATER (2004-2005) : Cergy-Pontoise University, (Prof T. Brigaud)
CNRS Temporary Researcher (2016-2018) : Laboratory of Biomolecules, Sorbonne University
Associate Professor (2005-2023) : CY Cergy Paris University
Full Professor (since 2023) : CY Cergy Paris University

Funded project
Coordinator of ANR « Young Researchers » Program 2009-2012 « CF3-GPE »
Initiative d’Excellence Paris//Seine Post-doc Program 2017 « F-LAIR »
Initiative d’Excellence Paris//Seine Post-doc Program 2019 « FluoSPep »
EUTOPIA PhD cotutelle 2020-2024 « EXPLORE »

Awards
Prime d’Excellence Scientifique (PES) 2010-2014
Prime d’Encadrement Doctoral et de Recherche (PEDR) 2014-2018
Prime d’Encadrement Doctoral et de Recherche (PEDR) 2020-2024

Scientific production

32 publications and 22 proceedings (h-index = 16), 9 seminars (2 to foreign Universities), 10 oral communications (1 as invited speaker) and 111 posters.