BioCIS - Biomolécules : Conception, Isolement et Synthèse

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ANR projects

ANR Flash COVID-19 - AAP HT COVID : Very high throughput optimized screening for the development of antiviral drug candidates targeting SARSCoV-2
INCa – PRTK 2019 : Therapeutic targeting of the Hepatic Leukemia Factor in triple negative breast cancers
LeishmaStop : We have identified inhibitors efficiently protecting cells against Leishmania infantum.
F-LAIR : Fluorinated Ligands Approach for the Inhibition of Rotamases.
THERMONAPOL : Thermosensitive polymer nanoparticles for ultrasound-targeted delivery.
X-COMIC : Chalcitrin and sclerocitrin: how nature can produce chemical diversity?
NICOFIVE : Discovery of allosteric modulators specifically targeting α5-containing nAChRs

Mount Indole : Mountains to Climb in the Chemistry of Highly Complex Indole Alkaloids: Methodology for Total Synthesis Innovative DNA-hybrid catalysis.
D-CYSIV : Innovative strategy for DNA-based asymmetric catalysis.
CarNuCat : Sucres Nucléophiles, Nouveaux Partenaires dans les Couplages métallocatalysés

NUTS : L’hypertension artérielle pulmonaire (HTAP) est une maladie rare, sévère et incurable, à l’origine d’une défaillance cardiaque droite.
PENTAGATE : Mechanisms of activation and desensitization of a pentameric channel receptor.

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Laurent Evanno and Erwan Poupon for SYNTHESIS and Frank Glorius for SYNLETT, together with their co-authors, are the recipients of the 2015 Best Paper Awards.

We are delighted to announce that Laurent Evanno (right) and Erwan Poupon (left) from the Université Paris-Sud in Châtenay-Malabry (France) are honored with the SYNTHESIS Best Paper Award 2015. Together with their co-workers they receive the prize for their Feature Article on Harnessing the Intrinsic Reactivity within the Aplysinopsin Series for the Synthesis of Intricate Dimers: Natural from Start to Finish. According to Paul Knochel, Editor-in-Chief of SYNTHESIS, Laurent Evanno and Erwan Poupon describe “in an elegant way how the consideration of biosynthetic aspects has led to the first total synthesis of dictazole B and its cyclobutane analogue. Their total synthesis of tubastrindole B has been achieved through a very original ring expansion starting from the dictazole precursor. In summary, a remarkable work clearly deserving the merits for best paper in 2015.”