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Accueil > Teams > Pharmacognosy - Chemistry of Natural Products > X-COMIC : Chalcitrin and sclerocitrin: how nature can produce chemical diversity?

X-COMIC : Chalcitrin and sclerocitrin: how nature can produce chemical diversity?

The team of “Chimie des Substances Naturelles” (L. Evanno) is funded by the young researcher program of ANR for the project X-comic. The overall objective is to demonstrate how Nature is able to assemble simple chemical building blocks and increment structural complexity to produce highly refined natural products. In this context, chalcitrin and sclerocitrin, two pigments displaying highly complex molecular structures isolated from common mushroom represent ambitious synthetic targets. This proposal of fundamental organic chemistry got the aim of synthesize highly complex molecule, and to afford a better understanding of their biosynthesis and their ecological significance. In the context of chemical ecology, identify biosynthetic intermediates and new scaffolds from mushrooms extracts. This project is at the interface of biosynthesis, biomimetic total synthesis and identification of natural products.