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Accueil > Teams > Pharmacognosy - Chemistry of Natural Products > Our books or covers paper > Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one β-Carboline Series and Study of Phenotypic Properties on C. elegans (Eur. J. Org. Chem. 26/2013)

Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one β-Carboline Series and Study of Phenotypic Properties on C. elegans (Eur. J. Org. Chem. 26/2013)

Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one β-Carboline Series and Study of Phenotypic Properties on C. elegans (Eur. J. Org. Chem. 26/2013)

Gerardo Cebrián-Torrejón, Nicolas Mackiewicz, Rafael P. Vázquez-Manrique, Alain Fournet, Bruno Figadère, Julien Nicolas and Erwan Poupon Article first published online : 4 SEP 2013 | DOI : 10.1002/ejoc.201390073

The cover picture shows an intricate combination of elements tracing the different aspects of the paper by E. Poupon et al. Leaves and fruits of Zanthoxylum chiloperone var. angustifolium, a tree growing in Paraguay from which the alkaloid canthin-6-one is extracted, appear in the background along with microscopic views of nanoparticles. In this paper, the biosynthetic pathway of this small β-carboline alkaloid has been mimicked in the lab through chemical synthesis including mimicry of a crucial step from a precursor covalently grafted onto a nanoparticle-forming polymer. Crossing the cover picture, specimens of Caenorhabditis elegans illustrate part of the work dedicated to a better understanding of the role of canthin-6-one in terms of chemical ecology. Details of this work are described in the Full Paper by E. Poupon et al. on

http://dx.doi.org/10.1002/ejoc.201300770