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Accueil > Teams > Pharmacognosy - Chemistry of Natural Products > Our books or covers paper > Sesquiterpenic Quinones in Two Different Dactylospongia Species

Sesquiterpenic Quinones in Two Different Dactylospongia Species

Asmaa Boufridi, David Lachkar, Dirk Erpenbeck, Mehdi A. Beniddir, Laurent Evanno, Sylvain Petek, Cécile Debitus and Erwan Poupon

Dactylospongia metachromia and Dactylospongia elegans collected from French Polynesia were studied with a particular focus on the variation of the diastereomeric ratio between ilimaquinone and 5-epi-ilimaquinone. More than 100 samples, covering an area of 4100 km2, were studied to try to clarify this intriguing issue. Nuclear magnetic resonance appeared as the non-destructive, straightforward technique of choice for a relative quantitative study. A random distribution, unique at that point in nature, is observed and leads to biosynthetic considerations. Biological evaluation of both compounds was also performed and showed moderate discrepancies in cytotoxicity and apoptosis induction.

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