2015
192. Synthesis of Biheterocycles based on Quinolinone, Chromone and Coumarin scaffolds by Palladium-Catalyzed Decarboxylative Couplings. Vardhan Reddy, K. H. ; Nageswar, Y. V. D. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. J. Org. Chem. 2015, accepted.
191. Diversty-oriented synthesis of fused thioglycosyl benzo[e][1,4]oxathiepin-5-ones and benzo[f][1,4]thiazepin-5(2H)-ones by a sequence of palladium-catalyzed glycosyl thiol arylation and deprotection-lactonization reactions. Atto Al-Shueeb, R. A. ; Galvani, G. ; Bernadat, G. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Org. Biomol. Chem. 2015, 13, 10904–10916.
190. Transition Metal-free Synthesis of Polysubstituted Cyclopropane Derivatives from N-tosylhydrazones and Their Cytotoxic Activities. Lawson, M. ; Bignon, J. ; Brion, J.-D. ; Hamze, A. ; Alami, M. Asian J. Org. Chem. 2015, 4, 1144-1154.
189. Synthesis of Benzofulvenes Through Chemoselective Sonogashira, Barluenga Couplings of ortho Ethynyl N-Tosylhydrazones and Cycloisomerization. Aziz, J. ; Brion, J.-D. ; Alami, M. ; Hamze, A. RSC. Adv. 2015, 5, 74391-74398.
188. Novel adamantane and memantine derivatives as peripheral NMDA receptor antagonists. Alami, M. ; Cohen-Kaminsky, S. ; Messaoudi, S. ; Brion, J.-D. ; Galvani, G. ; Dumas, S. ; Bru-Mercier, G. ; Humbert, M. Eur. Patent EP15306228, 28 Juillet 2015.
187. Palladium catalysed tandem reaction of hydrazones, dihaloarenes and organoboron reagents. Roche, M. ; Salim, S. M. ; Brion, J.-D. ; Alami, M. ; Hamze, A. J. Org. Chem. 2015, 80, 6715-6727.
186. Isocombretaquinazolines : Novel potent cytotoxic agents with antitubulin activity. Soussi, M. A. ; Provot, O. ; Bernadat, G. ; Bignon, J. ; Desravines, D. ; Dubois, J. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. ChemMedChem. 2015, 10, 1392-1402.
185. General and Stereoretentive Palladium-Catalyzed Arylation, Alkenylation and Alkynylation of Thioglycosides by Using Aminobiphenyl Palladacycle Precatalyst at Room Temperature. Bruneau, A. ; Roche, M. ; Hamze, A. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Chem. Eur. J. 2015, 21, 8375-8379.
184. Palladium-Catalyzed Coupling of N-aminoazoles with 3-Halo-substituted quinolin-2(1H)-ones, Coumarins, -Quinoxalin-2(1H)-ones and Chromenes. Luong, T. T. H. ; Brachet, E. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Eur. J. Org. Chem. 2015, 1771-1780.
183. 2-Aminobiphenyl Palladacycles : the most powerful precatalysts in C-C and C-heteroatom cross couplings. Bruneau, A. ; Roche, M. ; Alami, M. ; Messaoudi, S. ACS Catal. 2015, 5, 1386-1396.
182. Rapid synthesis of 4-arylchromens from ortho substituted arylalkynols : A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. Renko, D. ; Provot, O. ; Rasolofonjatovo, E. ; Bignon, J. ; Dubois, J. ; Brion, J.-D. ; Hamze, A. ; Alami, M. Eur. J. Med. Chem. 2015, 90, 834-844.
181. Synthesis of Fused 1-aminoindole Polycycles by a Sequence of Palladium-Catalyzed N-H and C(sp2)-H Arylations. Luong, T. T. H. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. J. Org. Chem. 2015, 80, 751-761.
180. Composés cytotoxiques inhibiteurs de la polymérisation de la tubuline. Alami, M. ; Brion, J.-D. ; Messaoudi, S. ; Provot, O. ; Soussi, M. A. ; Bignon, J. ; Dubois, J. ; Bakala-Wdzieczak, J. Brevet Français N° 1453142 ; 09 avril 2014. Etendu à l’international WO 2015/155261 A1.
2014
179. Sulfinate derivatives : Dual and versatile partners in organic synthesis. Aziz, J. ; Messaoudi, S. ; Alami, M. ; Hamze, A. Org. Biomol. Chem. 2014, 12, 9743-9759.
178. A general Pd/Cu-catalyzed C-H heteroarylation of 3 bromoquinolin-2(1H)-ones. Bruneau, A. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Org. Biomol. Chem. 2014, 12, 8533-8541.
177. Copper-Catalyzed Coupling between N-Tosylhydrazones and Amines : Synthesis of 9H-Fluoren-9-Amine Derivatives. Aziz, J. ; Frison, G. ; Gomez, M. ; Brion, J.-D. ; Hamze, A. ; Alami, M. ACS Catal. 2014, 4, 4498-4503.
176. Assisted tandem Pd(II)/Pd(0)-catalyzed C- and N- arylations of quinoxalin-2(1H)-ones in water. Carrër, A. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Adv. Synth. Catal. 2014, 356, 3821-3830.
175. Synthesis of a 3-(a-styryl)-disubstituted benzo[b]thiophenes analogue library via bromocyclization/palladium-catalyzed tosylhydrazones cross-couplings : evaluation as antitubulin antitumor agents. Tréguier, B. ; Lawson, M. ; Bernadat, G. ; Bignon, J. ; Dubois, J. ; Brion, J.-D. ; Alami, M. ; Hamze, A. ACS Comb. Sci. 2014, 16, 702-710
174. Tandem One-pot palladium-catalyzed coupling of hydrazones, haloindoles and amines. Synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells. Roche, M. ; Bignon, J. ; Brion, J.-D. ; Hamze, A. ; Alami, M. J. Org. Chem. 2014, 79, 7583-7592.
173. Synthesis and antiproliferative activity of novobiocin analogues as potential hsp90 inhibitors. Audisio, D. ; Methy-Gonnot, D. ; Radanyi, C. ; Renoir, J.-M., Denis, S. ; Sauvage, F. ; Vergnaud-Gauduchon, J. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Eur. J. Med. Chem. 2014, 83, 498-507.
172. Therapeutic modalities of squalenoyl nanocomposites in colon cancer : An ongoing search for improved efficacy. Maksimenko, A. ; Alami, M. ; Zouhiri, F. ; Brion, J.-D. ; Pruvost, A. ; Mougin, J. ; Hamze, A. ; Boissenot, T. ; Provot, O. ; Desmaële, D. ; Couvreur, P. ACS Nano 2014, 8, 2018-2032.
171. Discovery of azaisoerianin derivatives as potential antitumors agents. Soussi, M. A. ; Provot, O. ; Bernadat, G. ; Bignon, J. ; Wdzieczak-Bakala, J. ; Desravines, D. ; Dubois, J. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Eur. J. Med. Chem. 2014, 78, 178-189
170. Reversion of resistance of TP53 mutated Burkitt Lymphoma cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. Farhat, M. ; Poissonnier, A. ; Hamze, A. ; Ouk-Martin, C. ; Brion, J.-D. ; Alami, M. ; Feuillard, J. ; Jayat-Vignoles, C. Cell. Death Dis. 2014, 5, doi:10.1038/cddis.2014.150.
169. Coupling reactions between sp Carbon Centers. Alami, M. ; Hamze, A. ; Messaoudi, S. In Comprehensive Organic Synthesis, Molander, G. ; Knochel, P., 2nd Eds. ; Pergamon Press : Oxoford, UK, 2014, pp. 528-579. (book chapter on invitation)
2013
168. Nickel catalyzed arylation, alkenylation and alkynylation of unprotected thioglycosides at room temperature. Brachet, E. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Chem. Eur. J. 2013, 19, 15276.
167. Palladium(II)-catalyzed oxidative arylation of quinoxalin-2(1H)-ones with arylboronic acids. Carrër, A. Brion, J.-D. ; Messaoudi, S. Alami, M. Org. Lett. 2013, 15, 5606.
166. Gold versus Palladium : A regioselective cycloisomerization of aromatic enynes. Aziz, J. ; Frison, G. ; Le Menez, P. ; Brion, J.-D. ; Hamze, A. ; Alami, M. Adv. Synth. Catal. 2013, 355, 3425.
165. Nickel catalyzed arylation, alkenylation and alkynylation of unprotected thioglycosides at room temperature. Brachet, E. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Chem. Eur. J. 2013, doi:10.1002/ chem.201302999.
164. Csp2-N Bond Formation via Ligand-Free Pd-Catalyzed Oxidative Coupling Reaction of N-Tosylhydrazones and Indole Derivatives. Roche, M. ; Brion, J.-D. ; Hamze, A. ; Alami, M. J. Org. Chem. 2013, 78, 8485.
163. Stereoselective copper-catalyzed Chan-Lam-Evans N-arylation of glucosamines with arylboronic acids at room temperature. Bruneau A. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Chem. Commun. 2013, 49, 8359.
162. Stereoselective Palladium-Catalyzed Alkenylation and Alkynylation of Thioglycosides. Brachet, E. ; Brion, J.-D. ; Alami, M. ; Messaoudi, S. Adv. Synth. Catal. 2013, 355, 2627
161. Copper acetoacetonate [Cu(acac)2]/BINAP-Promoted Csp3-N Bond Formation via Reductive Coupling of N-Tosylhydrazones with Anilines. Aziz, J. ; Brion, J.-D. ; Hamze, A. ; Alami, M. Adv. Synth. Catal. 2013, 355, 2417.
160. Synthesis of 3,4-Disubstituted Quinolin-2-(1H)-ones via Palladium Catalyzed Decarboxylative Arylation Reactions. Carrër, A. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Adv. Synth. Catal. 2013, 355, 2044.
159. A New Strategy for Selective Targeting of Progesterone Receptor with Passive antagonists. Khan, J. A. ; Tikad, A. ; Fay, M. ; Hamze, A. ; Fagart, J. ; Chabert-Buffet, N. ; Meduri, G. ; Brion, J.-D. ; Alami, M. ; Lombès, M. ; Loosfelt, H. ; Rafestin-Oblin, M.-E. Mol. Endocrinology 2013, 27, 909-924.
158. A Palladium-catalyzed coupling of 3-chloro-quinoxalinones with various nitrogen-containing nucleophiles. Brachet, E. ; Peyrat, J.-F. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Org. Biomol. Chem. 2013, 11, 3808. (Journal cover picture)
157. An efficient Coupling of N-tosylhydrazones with 2-Halopyridines : Synthesis of alpha-Styrylpyridines endowed with antitumor activity. Lawson, M. Hamze, A. ; Peyrat, J.-F. ; Bignon, J. ; Dubois, J. ; Brion, J.-D. ; Alami, M. Org. Biomol. Chem. 2013, 11, 3664.
156. Discovery and hit to lead optimization of novel combretastatin A4 analogues : dependence of C-linker length and hybridization. Provot, O. ; Hamze, A. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Anti-Cancer Agents Med. Chem. 2013, 13, 1614. (Review on invitation)
155. Design, Synthesis and Anticancer Properties of Benzoxepines Derivatives as Conformationally Restricted isoCombretastatin A-4. Rasolofonjatovo, E. ; Provot, O. Hamze, A. ; Rodrigo, J. ; Bignon, J. ; Wdzieczak-Bakala, J. ; Desravines, D. ; Dubois, J. ; Brion, J.-D. ; Alami, M. Eur. J. Med. Chem. 2013, 53, 28.
154. Synthesis of Ortho/Ortho’-Substituted 1,1-Diarylethylenes through Cross-Coupling Reactions with Sterically Encumbered Hydrazones. Roche, M. ; Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. J. Org. Chem. 2013, 78, 445. (Highlighted Organic-Chemistry Portal (http://www.organic-chemistry.org/)
153. An efficient synthesis of 3-triazolyl-2(1H)-quinolones by copper(I)-catalyzed azide-alkyne cycloaddition reaction. Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Appl. Organometal. Chem. 2013, 27, 155.
152. Palladium-catalyzed croos coupling reaction of thioglycosides with (hetero)aryl halides. Brachet, E. ; Brion, J.-D. ; Messaoudi, S. ; Alami, M. Adv. Synth. Catal. 2013, 355, 477.
151. Catalytic Three-Component One-Pot Reaction of Hydrazones, Dihaloarenes and Amines. Roche, M. ; Hamze, A. ; Brion, J.-D. ; Alami, M. Org. Lett. 2013, 15, 148.
150. Synthesis, biological evaluation and structure activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors. Aziz, J. ; Brachet, E. ; Hamze, A. ; Peyrat, J.-F. ; Bernadat, G. ; Morvan, E. ; Bignon, J. ; Dubois, J. ; Wdzieczak-Bakala, J. ; Desravines, D. ; Dubois, J. ; Tueni, M. ; Yassine, A. ; Brion, J.-D. ; Alami, M. Org. Biomol. Chem. 2013, 11, 430 (journal cover picture).
149. Recent Advances in Hsp90 Inhibitors as Antitumor Agents. Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. in Advances in Anti-Cancer Agents in Medicinal Chemistry Ed. M. Prudhomme, Bentham Sciences Publishers 2013, 1, Chapter 4, pp 107-183 ISBN : 978-1-60805-712-2
2012
148. Hsp90 stabilises Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. Giessrigl, B. ; Krieger, S. ; Rosner, M. ; Huttary, N. ; Saiko, P. ; Alami, M. ; Messaoudi, S. ; Peyrat, J.-F. ; Maciuk, A. ; Gollinger, M. ; Kopf, S. ; Egidijus, K. ; Mazal, P. ; Szekeres, T. ; Hengstschläger, M. ; Matulis, D. ; Jäger, W. ; Krupitza, G. Hum. Mol. Genet. 2012, 21 4615-4627.
147. Synthetic 2-Methoxyestradiol : Structure-Activity Relationships. Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Curr. Med. Chem. 2012, 19, 4142 (Review on invitation)
146. Palladium-catalyzed cross-coupling of 1-aminoazoles with aryl chlorides : application to the synthesis of unsymmetrical N,N-diaryl-1-aminoindoles. Brachet, E. ; Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Adv. Synth. Catal. 2012, 354, 2829
145. Synthesis of 1,1-diarylethylenes via Efficient iron/copper cocatalyzed coupling of 1-phenylvinyl iodides with Grignard reagents. Hamze, A. ; Brion, J.-D. ; Alami, M. Org. Lett. 2012, 14, 2782.
144. Cs2CO3 in pyrrolidinone promoted hydration of functionalized (hetero)aryl nitriles under metal-free conditions. Sahnoun, S. ; Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2012, 53, 2860
143. Synthesis and antikinetoplastid activities of 3-substituted quinolinone derivatives. Audisio, D. ; Messaoudi, S. ; Cojean, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Bories, C. ; Huteau, F. ; Loiseau, P. ; Alami, M. Eur. J. Med. Chem. 2012, 52, 44.
142. Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues : Synthesis, cytotoxicity and antitubulin activity. Rasolofonjatovo, E. ; Provot, O. ; Hamze, A. ; Rodrigo, J. ; Bignon, J. ; Wdzieczak-Bakala, J. ; Desravines, D. ; Dubois, J. ; Brion, J.-D. ; Alami, M. Eur. J. Med. Chem. 2012, 52, 22.
141. Palladium-catalyzed decarboxylative coupling of quinolone-3-carboxylic acids and related heterocyclic carboxylic acids with (hetero)aryl halides. Messaoudi, S. ; Brion, J.-D. ; Alami, M. Org. Lett. 2012, 14, 1496.
140. A one-pot three-steps sequential synthesis of (Z)-trisubstituted olefins from arylalkynes and their cyclization into 4-aryl-2H-chromenes. Rasolofonjatovo, E. ; Tréguier, B. ; Provot, O. ; Hamze, A. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2012, 1603.
2011
139. Inhibitors of the heat shock protein 90 : from cancer clinical trials to neurodegenerative diseases. Peyrat, J.-F. ; Messaoudi, S. ; Brion, J.-D. ; Alami, M. Atlas Genet Cytogenet Oncol Haematol. 2011, 15, 89-105.
138. Synthesis of novel piperidyl spirofused benzofurans/benzopyrans by radical cyclization. Tang, Z. ; Mayrargue, J. ; Alami, M. J. Heterocyclic. Chem. 2011, 48, 1238-1242.
137. Progesterone receptor antagonists and use thereof. Oblin, M. E. ; Alami, M. ; Brion, J.-D. ; Tikad, A. ; Hamze, A. ; Fay, M. ; Loosfelt, H. ; Lombes, M. ; Fagart, J. ; Khan, J. A. ; Chabert-Buffet, N. ; Turque, N. Brevet INSERM-CNRS-UPS ; EP N°10305484.7 du 7 mai 2010 étendu à l’international PCT N° EP2011/057387 du 10 novembre 2011 (WO 2011/138460).
136. Novel B-Ring Modified isoCombretastatin A-4 Analogues Endowed with Interesting Anticancer Activities. Hamze, A. ; Provot, O. ; Mousset, C. ; Veau, D. ; Rasolofonjatovo, E. ; Rodrigo De Losada, J. ; Bignon, J. ; Liu, J.-M. ; Wdzieczak-Bakala, J. ; Thoret, S. ; Dubois, J. ; Brion, J.-D. ; Alami, M. ChemMedChem. 2011, 6, 2179-2191.
135. Copper-catalyzed direct amination of halo(hetero)arenes with sodium azide as the amino source. Messaoudi, S. ; Brion, J.-D. ; Alami, M. Mini-Rev. Org. Chem. 2011, 8, 448-454.
134. Heat Shock Protein 90 Inhibitors as Antitumor Agents : A Survey of the Literature from 2005 to 2010. Messaoudi, M. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Expert Opin. Ther. Pat. 2011, 21, 1501-1542.
133. Palladium-catalyzed coupling of 3-halo substituted coumarins, -chromenes and -quinolinones with various nitrogen-containing nucleophiles. Soussi, M. A. ; Audisio, D. ; Messaoudi, M. ; Provot, O. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2011, 5077.
132. The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes : Identification, Synthesis and Biological Evaluation of Metabolites. Soussi, M. A. ; Aprile, S. ; Messaoudi, S. ; Provot, O. ; Del Grosso, E. ; Bignon, J. ; Dubois, J. ; Brion, J.-D. ; Grosa, G. ; Alami, M. ChemMedChem. 2011, 6, 1781-1788
131. Synthesis of 2-(1-Phenylvinyl)benzofurans and 2-(1-Phenylvinyl)indoles as Antimitotic Agents by a Tandem Palladium-Assisted Coupling-Cyclization Reaction between 1-Phenylvinyl Iodides and ortho-Substituted Arylalkynes. Tréguier, B. ; Rasolofonjatovo, E. ; Hamze, A. ; Provot, O. ; Bignon, J. ; Dubois, J. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2011, 4868.
130. Copper-Catalyzed Reductive Coupling of Tosylhydrazones with Amines : A Convenient Route to -Branched Amines. Hamze, A. ; Brion, J.-D. ; Alami, M. Org. Biomol. Chem. 2011, 9, 6200.
129. A general copper powder-catalyzed Ullmann-type reaction of 3-halo-4(1H)-quinolones with various nitrogen-containing nucleophiles. Audisio, D. ; Messaoudi, M. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. J. Org. Chem. 2011, 76, 4995.
128. Palladium-catalyzed direct benzylation of xanthines. Sahnoun, S. ; Messaoudi, S. ; Brion, J.-D. ; Alami, M. ChemCatChem. 2011, 3, 893.
127. Palladium-catalyzed selective N-(hetero)arylation or N,N’-di(hetero)arylation of 1-aminoindoles. Messaoudi, S. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2011, 52, 2687.
126. Discovery and Biological Activity of 6BrCaQ as an inhibitor of the hsp90 protein folding machinery. Audisio, D. ; Messaoudi, S. ; Ceigeikowski, L. ; Peyrat, J.-F. ; Brion, J.-D. ; Methy-Gonnot, D. ; Radanyi, C. ; Renoir, J.-M. ; Alami, M. ChemMedChem. 2011, 6, 804.
125. Discovery of isoerianin analogues as promising anticancer agents. Messaoudi, S. ; Hamze, A. ; Provot, O. ; Tréguier, B ; Rodrigo De Losada, J. Bignon, J. ; Liu, J.-M. ; Wdzieczak-Bakala, J. ; Thoret, S. ; Dubois, J. ; Brion, J.-D. ; Alami, M. ChemMedChem. 2011, 6, 488.
124. Palladium-Catalyzed Coupling of N-Tosylhydrazones with Ortho Substituted Aryl Halides : Synthesis of 4-Arylchromenes and Related Heterocycles. Rasolofonjatovo, E. ; Tréguier, B. ; Provot, O. ; Hamze, A. ; Morvan, E. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2011, 52, 1036.
2010
123. Suzuki Coupling Reactions of (E)- and (Z)-Chloroenynes with Boronic Acids : A Versatile Access to Functionalized 1,3-Enynes. Tikad, A. ; Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2010, 725.
122. Bu3SnH in NMP Promoted Reduction of Acid Chlorides to Aldehydes under Metal-Free Conditions. Le Menez, P. ; Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Synlett. 2010, 1101.
121. Assessing the chemical diversity of an hsp90 knowledge database. Audisio, D. ; Messaoudi, S. ; Ijjaali, I. ; Dubus, E. ; Petitet, F. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Eur. J. Med. Chem. 2010, 45, 2000.
120. A simple synthesis of functionalized 3-bromocoumarins via a one-pot three-component reaction. Audisio, D. ; Messaoudi, S. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2010, 1046.
119. p-Toluenesulfonic Acid-Mediated Functionalization of Unsymmetrical Arylalkynes : A regioselective Access to various Arylketones and Heterocycles. Jacubert, M. ; Hamze, A. ; Provot, O. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Tetrahedron 2010, 66, 3775.
118. An expeditious copper-catalyzed access to 3-aminoquinolein-2-ones, 3-aminocoumarins and anilines using sodium azide. Messaoudi, S. ; Brion, J.-D. ; Alami, M. Adv. Synth. Catal. 2010, 352, 1677.
117. Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom : An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4. Rasolofonjatova, E. ; Provot, O. ; Hamze, A. ; Bignon, J. ; Thoret, S. ; Brion, J.-D. ; Alami, M. Eur. J. Med. Chem. 2010, 45, 3617.
116. Heat shock protein 90 inhibitors : From cancer clinical trials to neurodegenerative diseases. Peyrat, J.-F. ; Messaoudi, S. ; Brion, J.-D. ; Alami, M. Atlas Genet Cytogenet Oncol Haematol. April 2010, URL : http://AtlasGeneticsOncology.org/Deep/HSP90inCancerTreatmentID20086.html
115. MPHT promoted bromocyclization of ortho-substituted arylalkynes : Application to the synthesis of 2-substituted-3-bromo-benzofurans and benzo[b]thiophenes. Jacubert, M. ; Tikad, A. ; Provot, O. ; Hamze, A. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2010, 4492.
114. Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides : Synthesis of tetrasubstituted olefins related to isocombretastatn A4. Brachet, E. ; Hamze, A. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Org. Lett. 2010, 12, 4042.
113. Pd/Cu-catalyzed direct alkenylation of azole heterocycles with alkenyl halides. Sahnoun, S. ; Messaoudi, S. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2010, 6097.
112. Regioselective hydrostannation of hindred diarylalkynes under anti steric effect. Le Menez, P. ; Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Tetrahedron. 2010, 66, 8698.
111. Transition metal-catalyzed direct alkenylation, alkynylation and benzylation of (hetero)arene C–H Bonds. Messaoudi, S. ; Brion, J.-D. ; Alami, M. Eur. J. Org. Chem. 2010, 6495.
2009
110. Dihydro isoCA4 and potent cytotoxics inhibitors of tubulin polymerization. Alami, M. ; Brion, J.-D ; Messaoudi, S. ; Hamze, A. ; Provot, O. ; Bignon, J. ; Bakala-Wdzieczak, J. ; Liu, Jian-Miao Brevet-CNRS-UPS N° FR 08/53694 ; étendu à l’international PCT N° EP2009/056885 du 4 juin 2009 (WO 2009/147217 A1).
109. Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent hsp90 inhibitors in human cancer cells. Radanyi, C. ; Le Bras, G. ; Marsaud, V. ; Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. ; Renoir, J.-M. Cancer Letters 2009, 274, 88.
108. Tosylcyclonovobiocic acids promote cleavage oh the hsp90-associated cochaperone p23. Radanyi, C. ; Le Bras, G. ; Bouclier, C. ; Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. ; Renoir, J.-M. Biochem. Bioph. Res. Commun. 2009, 379, 514.
107. Palladium-Catalyzed Markovnikov Terminal Arylalkynes Hydrostannation : Application to the Synthesis of 1,1-Diarylethylenes. Hamze, A. ; Veau, D. ; Provot, O. ; Brion, J.-D. ; Alami, M. J. Org. Chem. 2009, 74, 1337.
106. p-Toluenesulfonic acid mediated cyclization of o-(1-Alkynyl)anisoles or thioanisoles : Synthesis of 2-Arylsubstituted Benzofuranes and Benzothiophenes. Jacubert, M. ; Hamze, A. ; Provot, O. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2009, 50, 3588.
105. Isocombretastatins A versus Combretastatins A : The Forgotten isoCA4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent. Messaoudi, S. ; Tréguier, T. ; Hamze, H. ; Provot, O. ; Peyrat, J.-F. ; De Losada, J. R. ; Liu, J.-M. ; Bignon, J. ; Wdzieczak-Bakala, J. ; Thoret, S. ; Dubois, J. ; Brion, J.-D. ; Alami, M. J. Med. Chem. 2009, 52, 4538.
104. A site selective C-H arylation of N6-free adenines with aryl chlorides : Application to the synthesis of N6/C8-disubstituted adenines. Sahnoun, S. ; Messaoudi, S. ; Brion, J.-D. ; Alami, M. Org. Biomol. Chem. 2009, 7, 4271.
103. Expeditious Synthesis of 1,1-Diarylethylenes Related to Isocombretastatin A4 (isoCA4) via Palladium-Catalyzed Arylation of N-Tosylhydrazones with Aryl Triflates. Tréguier, B. ; Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2009, 50, 6549.
102. Synthesis, Anticancer Activity of 1,1-Diarylethylenes as a Novel Class of Antimitotic Agents. Hamze, A. ; Giraud, A. ; Messaoudi, S. ; Provot, O. ; Peyrat, J.-F. ; Bignon, J. ; Liu, J.-M. ; Wdzieczak-Bakala, J. ; Thoret, S. ; Dubois, J. ; Brion, J.-D. ; Alami, M. ChemMedChem. 2009, 4, 1912.
2008
101. Crystal structure of 3-[(2,2-dimethylchroman-6-yl)carbonylamino]-7-hydroxy-8-methyl-2-oxo-2H-chromen-4-yl toluene-4-sulfonate, C19H27NO8S. Le Bras, G. ; Bekaert, A. ; Viossat, B. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. ; Lemoine, P. Z. Kristallogr. NCS 2008, 223, 16.
100. One-pot hydrosilylation-desilylation of diarylalkynes : A highly selective access to (Z)-stilbenes : Application to the synthesis of combrétastatin A4. Giraud, A. ; Provot, O. ; Hamze, A. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2008, 49, 1107.
99. Synthesis of poly(aryl propargyl ether) (PAPE) stars and evaluation of their cytotoxic Properties. L’Hermite, N. Peyrat, J.-F. ; Hildgen, P ; Brion, J.-D. ; Alami, M. Synthesis 2008, 1049.
98. Platinum chloride / Xphos-catalyzed regioselective hydrosilylation of terminal alkynes. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2008, 49, 2429.
97. Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat shock protein 90 (hsp90). Radanyi, C. ; Le Bras, G. ; Messaoudi, S. ; Bouclier, C. ; Peyrat, J.-F. ; Brion, J.-D. ; Marsaud, V. ; Renoir, J.-M. ; Alami, M. ; Bioorg. Med. Chem. Lett. 2008, 18, 2495.
96. DMSO/PdI2 a powerful oxidizing couple of alkynes into benzils : One pot synthesis of nitrogen-containing 5-, 6-membred heterocycles. Mousset, C. ; Provot, O. ; Hamze, A. ; Bignon, G. ; Brion, J.-D. ; Alami, M. Tetrahedron 2008, 64, 4287.
95. Synthesis of isocoumarins via PTSA-catalyzed annulation of diarylalcynes. Le Bras, G. ; Hamze, A. ; Messaoudi, S. ; Provot, O. ; Le Calvez, P.-B., Brion, J.-D. ; Alami, M. Synthesis 2008, 1607.
94. Synthesis and antitumor activity of benzil compounds related to combretastatin A-4. Mousset, C. ; Giraud, A. ; Provot, O. ; Hamze, A. ; Brion, J.-D. ; Bignon, J. ; Liu, J. M. ; Wdzieczak-Bakala, J. ; Thoret, S. ; Dubois, J. ; Alami, M. Bioorg. Med. Chem. Lett. 2008, 18, 3266.
93. Xphos ligand and platinum catalysts : A versatile catalyst for the synthesis of functionalized beta-(E)-vinylsilanes from terminal alkynes. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. J. Organomet. Chem. 2008, 693, 2789.
92. Recent advances in Hsp90 inhibitors as antitumors agents. Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Curr. Med. Chem. Anti-Cancer Agents 2008, 8, 761.
91. Microwave Assisted Pd(OH)2-Catalyzed Direct C-H Arylation of Free-(NH2) Adenines with aryl Halides. Sahnoun, S. ; Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2008, 49, 7279.
2007
90. Regiocontrol of the palladium-catalyzed tin hydride addition to Z-enynols : Remakable Z-directing effects. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. J. Org. Chem. 2007, 72, 3868.
89. IsoCA4 and analogues thereof as potent cytotoxic agents inhibiting tubulin polymerization. Alami, M. ; Brion, J.-D ; Provot, O. ; Peyrat, J.-F. ; Messaoudi, S. ; Hamze, A. ; Giraud, A. ; Bignon, J. ; Bakala- Wdzieczak, J. ; Liu, Jian-Miao Brevet-CNRS-UPS N° 0754280 ; déposé le 04 avril 2007 ; étendu à l’international PCT N° EP2008/054118 du 4 avril 2008 (WO2008122620).
88. Palladium-mediated direct coupling of silylated aryl alkynes with propargylic halides : An efficient access to functionalized conjugated allenynes. Girard, D. ; Broussous, S. ; Provot, O. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2007, 48, 6022.
87. Regiochemical aspects of the platinum oxide-catalyzed hydrosilylation of alkynes. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Synthesis Special Topic 2007, 2025.
86. Rapid access to 3-(N-substituted)aminoquinolin-2(1H)-ones using palladium-catalyzed C-N bond coupling reaction. Messaoudi, S. ; Audisio, D. ; Brion, J.-D. ; Alami, M. Tetrahedron 2007, 63, 10202.
85. A convenient and expeditious synthesis of 3-(N-substituted)aminocoumarins via palladium-catalyzed Buchwald-Hartwig coupling reaction. Audisio, D. ; Messaoudi, S. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2007, 48, 6928.
84. Three-component one-pot process to aryl- or heteroaryl propargylic amines and related amide compounds : application to the construction of 2-(aminomethyl)benzofurans and indoles. Russo, O. ; Messaoudi, S. ; Hamze, A. ; Olivi, N. ; Peyrat, J.-F. ; Brion, J.-D. ; Sicsic, S. ; Berque-Bestel, I. ; Alami, M. Tetrahedron 2007, 63, 10671.
83. Synthesis of piperidine derivatives by reduction of pyridinium salts. Tang, Z. ; Mayrargue, J. ; Alami, M. Synthetic Commun. 2007, 37, 3367.
82. New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90. Le Bras, G. ; Radanyi, C. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. ; Marsaud, V. ; Stella, B. ; Renoir, J.-M. J. Med. Chem. 2007, 50, 6189.
81. Palladium-Mediated Synthesis of α-Vinylstannanes. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Synfact. 2007, 8, 839.
2006
80. alpha-iodination of ketones with MnO2/I2 reagent combination : A new environmentally friendly procedure. Le Bras, G. ; Provot, O ; Bekaert, A. ;.Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Synthesis 2006, 1537.
79. Antileishmanial activity of 2- or 3-quinolines. Seck, M. ; Desrivot, J. ; Bories, C. ; Loiseau, P. ; Franck, X. ; Hocquemiller, R. ; Figadère, B. ; Peyrat, J.-F. ; Provot, O. ; Brion, J.-D. ; Alami, M. Dakar Med. 2006, 50, 172-175.
78. Regioselective hydrosilylation of unsymmetrical aryl alkynes. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Synfacts 2006, 2, 127.
77. Platinum oxide-catalyzed silylation of aryl halides with triethylsilane : An efficient synthetic route to functionalized aryltriethylsilanes. Hamze, A. ; Provot, O. ; Alami, M. ; Brion, J.-D. Org. Lett. 2006, 8, 931.
76. Rapid microwave assisted hydration of internal arylalkynes in the presence of PTSA : An efficient regioselective access to carbonyl compounds. Le Bras, G. ; Provot, O. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2006, 47, 5497.
75. Microwave-assisted an efficient synthesis of 1,2-diarylketones ; A novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3. Giraud, A. ; Provot, O. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron 2006, 62, 7667.
74. Activité anti leishmanienne de cinq quinoléines substituées en position 2- ou 3- par un groupement ényne. Seck, M. ; Desrivot, J. ; Bories, C. ; Loiseau, P. ; Franck, X. ; Hocquemiller, R. ; Figadère, B. ; Peyrat, J.-F. ; Provot, O. ; Brion, J.-D. ; Alami, M. Dakar Med. 2006, 51, 1-4.
73. Disproportionation reaction of diarylcarbinols : A versatile access to diarylmethanes speed up using microwave irradiation. L’Hermite, N. ; Giraud, A. ; Provot, O. ; Peyrat, J.-F. ; Brion, J.-D. ; Alami, M. Tetrahedron 2006, 62, 11994.
72. Platinum oxide catalyzed silylation of aryl halides with triethylsilane. Hamze, A. ; Provot, O. ; Brion, J.-D. ; Alami, M. Synfacts 2006, 5, 495.
71. Crystal structure of cyclonovobiocin, C44H42N2O12. Le Bras, G. ; Bekaert, A. ; Viossat, B. ; Peyrat, J.-F. ; Brion, J.-D. ; Lemoine, P. ; Alami, M. Z. Kristallogr. NCS 2006, 221, 381.
2005
70. N-Methylpyrrolidin-2-one hydrotribromide (MPHT) a mild reagent for selective bromination of carbonyl compounds : synthesis of substituted 2-bromo-1-naphtols. Bekaert, A. ; Provot, O. ; Rasolojaona, O. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2005, 46, 4187.
69. beta-Lactamines. Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. in Pharmacothérapie pratique à l’officine : l’essentiel, Antibiotiques : pharmacologie et thérapeutique, Gaudy, C. ; Buxeraud, J. ; collection Pharma, Editions ELSEVIER ; 2005, p31-111.
68. Aminosides. Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. in Pharmacothérapie pratique à l’officine : l’essentiel, Antibiotiques : pharmacologie et thérapeutique, Gaudy, C. ; Buxeraud, J. ; collection Pharma, Editions ELSEVIER ; 2005, p113-131.
67. Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol. Hamze, A. ; Provot, O. ; Alami, M. ; Brion, J.-D. Org. Lett. 2005, 7, 5625.
66. Synthetic approach to enyne and enediyne analogues of anticancer agents. Provot, O. ; Giraud, A. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2005, 46, 8547.
65. Synthesis and characterization of low generation halogenated linear poly(arylpropargyl)ether (PAPE) branches via selective palladium catalyzed coupling reactions. L’Hermite, N. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2005, 46, 8987.
2004
64. Synthesis of substituted quinolines by iron catalysed coupling reaction between chloroenynes and Grignard reagents. Seck, M. ; Franck, X. ; Hocquemiller, R. ; Figadère, B. ; Peyrat, J.-F. ; Provot, O. ; Brion, J.-D. ; Alami, M. Tetrahedron Lett. 2004, 45, 1881.
63. Tandem amine propargylation-Sonogashira reactions : New three-component coupling leading to functionalized propargylic amines. Olivi, N. ; Spruyt, P. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2004, 45, 2607.
62. Highly substituted enynes via a palladium catalyzed tandem three carbon-carbon bonds forming reaction procedure from benzyl halides and tributyltin reagents. Pottier, L.R. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2004, 45, 4035.
61. Unexpected tandem Sonogashira-carbopalladation-Sonogashira coupling reaction of benzyl halides with terminal alkynes : A novel four component domino sequence to highly functionnalized substituted enynes. Pottier, L. R. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Synlett. 2004, 1503.
60. Highly Efficient p-toluenesulfonic acid-catalyzed alcohol addition or hydration of unsymmetrical arylalkynes. Olivi, N. ; Thomas, E. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Synlett. 2004, 2175.
59. A two step synthesis of aminopropylpiperidines via aminopropargylpyridines suitable for the synthesis of a new class of 5-HT4 ligands. Russo, O. ; Alami, M. ; Brion, J.-D. ; Sicsic, S. ; Berque-Bestel, I. Tetrahedron Lett. 2004, 45, 7069.
58. Iron-catalyzed coupling reactions between 1,1-dichloro-1-alkenes and Grignard reagents. Dos Santos, M. ; Franck, X. ; Hocquemiller, R. ; Figadère, B. ; Peyrat, J.-F. ; Provot, O. ; Brion, J.-D. ; Alami, M. Synlett. 2004, 2697.
2003
57. Palladium-catalyzed stereoselective synthesis of E- and Z-1,1-diaryl or triarylolefins. Liron, F. ; Gervais, M. ; Peyrat, J.-F. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2003, 44, 2789.
56. Iterative Procedure for the Synthesis of Conjugated omega-Chlorotri-, Tetraenoic esters and Related Derivatives. Mladenova, M. ; Tavlinova, M. ; Momchev, M. ; Alami, M. ; Ourévitch, M. ; Brion, J.-D. Eur. J. Org. Chem. 2003, 2713.
55. Versatile palladium(II)-catalyzed Negishi coupling reactions with functionalised conjugated alkenyl chlorides. Peyrat, J.-F. ; Thomas, E. ; L’Hermite, N. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2003, 44, 6703.
2002
54. Ortho Substituents Directed Regioselective Addition of Tributyltin Hydride to Unsymmetrical Diaryl (or Heteroaryl) Alkynes : An Efficient Route to Stannylated Stilbene Derivatives. Alami, M. ; Liron, F. ; Gervais, M. ; Peyrat, J.-F. ; Brion, J.-D. Angew. Chem. Int. Ed. 2002, 41, 1578.
53. Stereoselective Synthesis of (E)-Chloroenynes Starting from Stereoisomeric mixtures of 1,2-Dichloroethylenes. Alami, M. ; Peyrat, J.-F. ; Brion, J.-D. Tetrahedron Lett. 2002, 43, 3007.
2001
52. Weakly Ligated Palladium Complexes PdCl2(RCN)2 in Piperidine : Versatile Catalysts for Sonogashira Reaction of Vinyl Chlorides at Room Temperature. Alami, M. ; Crousse, B. ; Ferri, F. J. Organomet. Chem. 2001, 624, 114.
51. Versatile Palladium-Catalyzed Arylation of Organomanganese Chlorides by Aryl Bromides. Riguet, E. ; Alami, M. ; Cahiez, G. J. Organomet. Chem. 2001, 624, 376.
50. Synthesis of E and Z-Substituted Methylene-3,4-dihydro-2H-1-benzopyrans by Regio- and Stereocontrolled Palladium-Catalyzed Intramolecular Cyclization. Barberan, O. ; Alami, M. ; Brion, J.-D. Tetrahedron Lett. 2001, 42, 2657.
49. Efficient Syntheses of New Heteroarotinoids via Functional Pyridylzinc Reagent and Palladium Catalyzed Cross-Coupling Reactions. Alami, M. ; Peyrat, J.-F. ; Belachmi, L. ; Brion, J.-D. Eur. J. Org. Chem. 2001, 4207.
48. Kinetics of the Oxidative Addition of Ortho-Substituted Aryl Halides to Palladium Complexes. Alami, M. ; Amatore, C. ; Bensalem, S. ; Choukchou-Brahim, A. ; Jutand, A. Eur. J. Inorg. Chem. 2001, 2675.
2000
47. 1,2-Dihalogeno-Olefins : Useful Linchpins to Unsaturated Compounds via Palladium or Nickel-Catalysis. Alami, M. ; Peyrat, J.-F. ; Brion, J.-D. Synthesis 2000, 1499.
