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Accueil > Teams > Pharmacognosy - Chemistry of Natural Products > Our books or covers paper > Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease.

Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease.

Le Douaron G, Ferrié L, Sepulveda-Diaz JE, Séon-Méniel B, Raisman-Vozari R, Michel PP, Figadère B.

New 1,4,8-triazaphenanthrene derivatives were assessed for neuroprotection in a rat culture system that models the death of dopamine neurons in Parkinson’s disease. The cover picture illustrates the rescuing effects of the hit compound 3-phenyl-1,4,8-triazaphenanthrene (PPQ) for these neurons, i.e., cells immunolabeled for tyrosine hydroxylase. In the same study, the neuroprotective potential of PPQ was further established using a mouse model of the disease.

http://pubs.acs.org/doi/abs/10.1021/acschemneuro.6b00385