Understanding biosynthetic pathways and the role of natural substances in the context of chemical ecology and evolution in the era of "omics". The elucidation of biosynthetic pathways is now a strong theme of the team. From the genes involved in biosynthesis to the "intimate" mechanisms of complex skeletons formation through the characterization of enzymes, multiple collaborations are in place to help understand the emergence of molecular complexity in the living world. Evolutionary considerations are also at the heart of our reflections.