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Accueil > Teams > Pharmacognosy - Chemistry of Natural Products > ANR Mount Indole : Mountains to Climb in the Chemistry of Highly Complex Indole Alkaloids: Methodology for Total Synthesis Innovative DNA-hybrid catalysis

ANR Mount Indole : Mountains to Climb in the Chemistry of Highly Complex Indole Alkaloids: Methodology for Total Synthesis Innovative DNA-hybrid catalysis

We are currently partners of Mount Indole project, in collaboration with the " Méthodologie, Synthèse et Molécules Thérapeutiques" team at ICMMO (Dr Guillaume Vincent, Pr Cyrille Kouklovsky). New methodologies are studied towards the total synthesis of indole alkaloids. Moreover, we are also aiming at deciphering intimate mechanisms in the course of biosynthesis of highly complex monoterpene indole alkaloids. This diverse class of natural substances often displays impressive degrees of molecular complexity. At this time, the consortium has successfully achieved the biomimetic assembly of bipleiophylline.

lien : https://www.nature.com/articles/nchem.2735